Plant_lipase_EDS1-like

Relationship

Family: Plant_lipase_EDS1-like

Block: L

Parent Family: No family

Comment

Enhanced Disease Susceptibility 1 (EDS1), an essential component of R gene-mediated disease resistance. The Arabidopsis EDS1 (arath-eds1) and (phytoalexin-deficient 4) PAD4 (arath-PAD4) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4. EDS1 (arath-eds1) and PAD4 (arath-PAD4) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). This family is extracted from the Lipase3 gene family. The C-terminal domain known as the EP domain and its interface consists of hydrophobic interactions, salt bridges, and an extensive hydrogen bonding network. Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4) mediate TNL receptor defence signalling. (In the seed alignment and the HMM alignement the EP domain (not alpha/beta hydrolase domain) is excluded)

Database

Interpro : IPR000734 Lipase , IPR044214 EDS1-like , IPR041266 EDS1, EP domain EDS1_EP

PIRSF : No PIRSF

Pdoc : PDOC00110

Pfam : PF01764 Lipase_3 , PF18117 EDS1_EP

Prints : PR00821

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (11)

Genes Proteins in Plant_lipase_EDS1-like family (167)

Fragments of genes in Plant_lipase_EDS1-like family (15)

Structures in Plant_lipase_EDS1-like family (11)

Substrates in Plant_lipase_EDS1-like family (3)

No Inhibitor

References (16)

Title : METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress - Bernacki_2024_Int.J.Mol.Sci_25_3195
Author(s) : Bernacki MJ , Rusaczonek A , Golebiewska K , Majewska-Fala AB , Czarnocka W , Karpinski SM
Ref : Int J Mol Sci , 25 :3195 , 2024
PubMedID: 38542169

Title : The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis - Wang_2023_Plant.Cell__
Author(s) : Wang H , Song S , Gao S , Yu Q , Zhang H , Cui X , Fan J , Xin X , Liu Y , Staskawicz B , Qi T
Ref : Plant Cell , : , 2023
PubMedID: 37851863

Title : Plant immune signaling network mediated by helper NLRs - Gong_2023_Curr.Opin.Plant.Biol_73_102354
Author(s) : Gong Y , Tian L , Kontos I , Li J , Li X
Ref : Curr Opin Plant Biol , 73 :102354 , 2023
PubMedID: 37003229

Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__
Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE
Ref : Plant J , : , 2022
PubMedID: 35324052
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335
Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE
Ref : Nat Commun , 12 :3335 , 2021
PubMedID: 34099661
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Origins and Immunity Networking Functions of EDS1 Family Proteins - Lapin_2020_Annu.Rev.Phytopathol__
Author(s) : Lapin D , Bhandari DD , Parker JE
Ref : Annu Rev Phytopathol , : , 2020
PubMedID: 32396762

Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430
Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE
Ref : Plant Cell , 31 :2430 , 2019
PubMedID: 31311833
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Comparative genomic analysis of the Lipase3 gene family in five plant species reveals distinct evolutionary origins - Wang_2018_Genetica_146_179
Author(s) : Wang D , Zhang L , Hu J , Gao D , Liu X , Sha Y
Ref : Genetica , 146 :179 , 2018
PubMedID: 29468429

Title : Rice OsPAD4 functions differently from Arabidopsis AtPAD4 in host-pathogen interactions - Ke_2014_Plant.J_78_619
Author(s) : Ke Y , Liu H , Li X , Xiao J , Wang S
Ref : Plant J , 78 :619 , 2014
PubMedID: 24617729
Gene_locus related to this paper: orysa-q53lh1

Title : EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora - Moreau_2012_Mol.Plant.Microbe.Interact_25_421
Author(s) : Moreau M , Degrave A , Vedel R , Bitton F , Patrit O , Renou JP , Barny MA , Fagard M
Ref : Mol Plant Microbe Interact , 25 :421 , 2012
PubMedID: 22316300
Gene_locus related to this paper: arath-eds1

Title : In silico study of interaction between rice proteins enhanced disease susceptibility 1 and phytoalexin deficient 4, the regulators of salicylic acid signalling pathway - Singh_2012_J.Biosci_37_563
Author(s) : Singh I , Shah K
Ref : J Biosci , 37 :563 , 2012
PubMedID: 22750992
Gene_locus related to this paper: orysa-q6h415 , orysa-q53lh1

Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245
Author(s) : Wagner S , Rietz S , Parker JE , Niefind K
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011
PubMedID: 21301097
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : A functional EDS1 ortholog is differentially regulated in powdery mildew resistant and susceptible grapevines and complements an Arabidopsis eds1 mutant - Gao_2010_Planta_231_1037
Author(s) : Gao F , Shu X , Ali MB , Howard S , Li N , Winterhagen P , Qiu W , Gassmann W
Ref : Planta , 231 :1037 , 2010
PubMedID: 20145949
Gene_locus related to this paper: arath-eds1

Title : Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response - Garcia_2010_PLoS.Pathog_6_e1000970
Author(s) : Garcia AV , Blanvillain-Baufume S , Huibers RP , Wiermer M , Li G , Gobbato E , Rietz S , Parker JE
Ref : PLoS Pathog , 6 :e1000970 , 2010
PubMedID: 20617163
Gene_locus related to this paper: arath-eds1

Title : Plant immunity: the EDS1 regulatory node - Wiermer_2005_Curr.Opin.Plant.Biol_8_383
Author(s) : Wiermer M , Feys BJ , Parker JE
Ref : Curr Opin Plant Biol , 8 :383 , 2005
PubMedID: 15939664
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases - Falk_1999_Proc.Natl.Acad.Sci.U.S.A_96_3292
Author(s) : Falk A , Feys BJ , Frost LN , Jones JDG , Daniels MJ , Parker JE
Ref : Proceedings of the National Academy of Sciences of the United States of America , 96 :3292 , 1999
PubMedID: 10077677
Gene_locus related to this paper: arath-eds1