arath-eds1

Arabidopsis thaliana lipase homolog (EDS1) (Enhanced disease susceptibility 1-like) At3g48090 AtEDS1

Comment

EDS1, an essential component of R gene-mediated disease resistance || The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance.EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1\/EDS1\/SAG101 and ADR1\/EDS1\/PAD4) mediate TNL receptor defence signalling

Relationship

Family : Plant_lipase_EDS1-like

Block : L

Position in NCBI Life Tree : Arabidopsis thaliana

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > malvids N E > Brassicales N E > Brassicaceae N E > Camelineae N E > Arabidopsis N E > Arabidopsis thaliana N E

Sequence

Peptide

MAFEALTGIN GDLITRSWSA SKQAYLTERY HKEEAGAVVI FAFQPSFSEK DFFDPDNKSS FGEIKLNRVQ FPCMRKIGKG DVATVNEAFL KNLEAVIDPR TSFQASVEMA VRSRKQIVFT GHSSGGATAI LATVWYLEKY FIRNPNVYLE PRCVTFGAPL VGDSIFSHAL GREKWSRFFV NFVTRFDIVP RITLARKASV EETLPHVLAQ LDPRNSSVQE SEQRITEFYT SVMRDTSTVA NQAVCELTGS AEAILETLSS FLELSPYRPA GTFVFSTEKR LVAVNNSDAI LQMLFYTCQA SDEQEWSLIP FRSIRDHHSY EELVQSMGMK LFNHLDGENS IESSLNDLGV STRGRQYVQA ALEEEKKRVE NQKKIIQVIQ QERFLKKLAW IEDEYKPKCQ AHKNGYYDSF KVSNEENDFK ANVKRAELAG VFDEVLGLLK KCQLPDEFEG DIDWIKLATR YRRLVEPLDI ANYHRHLKNE DTGPYMKRGR PTRYIYAQRG YEHHILKPNG MIAEDVFWNK VNGLNLGLQL EEIQETLKNS GSECGSCFWA EVEELKGKPY EEVEVRVKTL EGMLREWITA GEVDEKEIFL EGSTFRKWWI TLPKNHKSHS PLRDYMMDEI TDT

References (24)

Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__
Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE
Ref : Plant J , : , 2022
PubMedID: 35324052
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity - Huang_2022_Science_377_eabq3297
Author(s) : Huang S , Jia A , Song W , Hessler G , Meng Y , Sun Y , Xu L , Laessle H , Jirschitzka J , Ma S , Xiao Y , Yu D , Hou J , Liu R , Sun H , Liu X , Han Z , Chang J , Parker JE , Chai J
Ref : Science , 377 :eabq3297 , 2022
PubMedID: 35857645
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335
Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE
Ref : Nat Commun , 12 :3335 , 2021
PubMedID: 34099661
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430
Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE
Ref : Plant Cell , 31 :2430 , 2019
PubMedID: 31311833
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Arabidopsis immunity regulator EDS1 in a PAD4\/SAG101-unbound form is a monomer with an inherently inactive conformation - Voss_2019_J.Struct.Biol_208_107390
Author(s) : Voss M , Toelzer C , Bhandari DD , Parker JE , Niefind K
Ref : J Struct Biol , 208 :107390 , 2019
PubMedID: 31550533
Gene_locus related to this paper: arath-eds1

Title : Contrasting Roles of the Apoplastic Aspartyl Protease APOPLASTIC, ENHANCED DISEASE SUSCEPTIBILITY1-DEPENDENT1 and LEGUME LECTIN-LIKE PROTEIN1 in Arabidopsis Systemic Acquired Resistance - Breitenbach_2014_Plant.Physiol_165_791
Author(s) : Breitenbach HH , Wenig M , Wittek F , Jorda L , Maldonado-Alconada AM , Sarioglu H , Colby T , Knappe C , Bichlmeier M , Pabst E , Mackey D , Parker JE , Vlot AC
Ref : Plant Physiol , 165 :791 , 2014
PubMedID: 24755512
Gene_locus related to this paper: arath-eds1

Title : Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity - Wagner_2013_Cell.Host.Microbe_14_619
Author(s) : Wagner S , Stuttmann J , Rietz S , Guerois R , Brunstein E , Bautor J , Niefind K , Parker JE
Ref : Cell Host Microbe , 14 :619 , 2013
PubMedID: 24331460
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis - Kim_2012_Plant.Cell_24_5177
Author(s) : Kim TH , Kunz HH , Bhattacharjee S , Hauser F , Park J , Engineer C , Liu A , Ha T , Parker JE , Gassmann W , Schroeder JI
Ref : Plant Cell , 24 :5177 , 2012
PubMedID: 23275581
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora - Moreau_2012_Mol.Plant.Microbe.Interact_25_421
Author(s) : Moreau M , Degrave A , Vedel R , Bitton F , Patrit O , Renou JP , Barny MA , Fagard M
Ref : Mol Plant Microbe Interact , 25 :421 , 2012
PubMedID: 22316300
Gene_locus related to this paper: arath-eds1

Title : Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity - Rietz_2011_New.Phytol_191_107
Author(s) : Rietz S , Stamm A , Malonek S , Wagner S , Becker D , Medina-Escobar N , Vlot AC , Feys BJ , Niefind K , Parker JE
Ref : New Phytol , 191 :107 , 2011
PubMedID: 21434927
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators - Bhattacharjee_2011_Science_334_1405
Author(s) : Bhattacharjee S , Halane MK , Kim SH , Gassmann W
Ref : Science , 334 :1405 , 2011
PubMedID: 22158819
Gene_locus related to this paper: arath-eds1

Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245
Author(s) : Wagner S , Rietz S , Parker JE , Niefind K
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011
PubMedID: 21301097
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Arabidopsis EDS1 connects pathogen effector recognition to cell compartment-specific immune responses - Heidrich_2011_Science_334_1401
Author(s) : Heidrich K , Wirthmueller L , Tasset C , Pouzet C , Deslandes L , Parker JE
Ref : Science , 334 :1401 , 2011
PubMedID: 22158818
Gene_locus related to this paper: arath-eds1

Title : A functional EDS1 ortholog is differentially regulated in powdery mildew resistant and susceptible grapevines and complements an Arabidopsis eds1 mutant - Gao_2010_Planta_231_1037
Author(s) : Gao F , Shu X , Ali MB , Howard S , Li N , Winterhagen P , Qiu W , Gassmann W
Ref : Planta , 231 :1037 , 2010
PubMedID: 20145949
Gene_locus related to this paper: arath-eds1

Title : Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis - Straus_2010_Plant.J_62_628
Author(s) : Straus MR , Rietz S , Ver Loren van Themaat E , Bartsch M , Parker JE
Ref : Plant J , 62 :628 , 2010
PubMedID: 20163553
Gene_locus related to this paper: arath-eds1

Title : Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response - Garcia_2010_PLoS.Pathog_6_e1000970
Author(s) : Garcia AV , Blanvillain-Baufume S , Huibers RP , Wiermer M , Li G , Gobbato E , Rietz S , Parker JE
Ref : PLoS Pathog , 6 :e1000970 , 2010
PubMedID: 20617163
Gene_locus related to this paper: arath-eds1

Title : Arabidopsis thaliana genes encoding defense signaling and recognition proteins exhibit contrasting evolutionary dynamics - Caldwell_2009_Genetics_181_671
Author(s) : Caldwell KS , Michelmore RW
Ref : Genetics , 181 :671 , 2009
PubMedID: 19064707
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs - Iida_2009_DNA.Res_16_155
Author(s) : Iida K , Fukami-Kobayashi K , Toyoda A , Sakaki Y , Kobayashi M , Seki M , Shinozaki K
Ref : DNA Research , 16 :155 , 2009
PubMedID: 19423640
Gene_locus related to this paper: arath-AT2G42690 , arath-AT5G20060 , arath-eds1 , arath-MES2 , arath-o65713 , arath-pip , arath-Q8LFB7 , arath-q66gm8 , arath-B9DFR3

Title : Plant immunity: the EDS1 regulatory node - Wiermer_2005_Curr.Opin.Plant.Biol_8_383
Author(s) : Wiermer M , Feys BJ , Parker JE
Ref : Curr Opin Plant Biol , 8 :383 , 2005
PubMedID: 15939664
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity - Feys_2005_Plant.Cell_17_2601
Author(s) : Feys BJ , Wiermer M , Bhat RA , Moisan LJ , Medina-Escobar N , Neu C , Cabral A , Parker JE
Ref : Plant Cell , 17 :2601 , 2005
PubMedID: 16040633
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 , arath-T17F15.50

Title : Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4 - Feys_2001_EMBO.J_20_5400
Author(s) : Feys BJ , Moisan LJ , Newman MA , Parker JE
Ref : EMBO Journal , 20 :5400 , 2001
PubMedID: 11574472
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana - Salanoubat_2000_Nature_408_820
Author(s) : Salanoubat M , Lemcke K , Rieger M , Ansorge W , Unseld M , Fartmann B , Valle G , Blocker H , Perez-Alonso M , Obermaier B , Delseny M , Boutry M , Grivell LA , Mache R , Puigdomenech P , de Simone V , Choisne N , Artiguenave F , Robert C , Brottier P , Wincker P , Cattolico L , Weissenbach J , Saurin W , Quetier F , Schafer M , Muller-Auer S , Gabel C , Fuchs M , Benes V , Wurmbach E , Drzonek H , Erfle H , Jordan N , Bangert S , Wiedelmann R , Kranz H , Voss H , Holland R , Brandt P , Nyakatura G , Vezzi A , D'Angelo M , Pallavicini A , Toppo S , Simionati B , Conrad A , Hornischer K , Kauer G , Lohnert TH , Nordsiek G , Reichelt J , Scharfe M , Schon O , Bargues M , Terol J , Climent J , Navarro P , Collado C , Perez-Perez A , Ottenwalder B , Duchemin D , Cooke R , Laudie M , Berger-Llauro C , Purnelle B , Masuy D , de Haan M , Maarse AC , Alcaraz JP , Cottet A , Casacuberta E , Monfort A , Argiriou A , Flores M , Liguori R , Vitale D , Mannhaupt G , Haase D , Schoof H , Rudd S , Zaccaria P , Mewes HW , Mayer KF , Kaul S , Town CD , Koo HL , Tallon LJ , Jenkins J , Rooney T , Rizzo M , Walts A , Utterback T , Fujii CY , Shea TP , Creasy TH , Haas B , Maiti R , Wu D , Peterson J , Van Aken S , Pai G , Militscher J , Sellers P , Gill JE , Feldblyum TV , Preuss D , Lin X , Nierman WC , Salzberg SL , White O , Venter JC , Fraser CM , Kaneko T , Nakamura Y , Sato S , Kato T , Asamizu E , Sasamoto S , Kimura T , Idesawa K , Kawashima K , Kishida Y , Kiyokawa C , Kohara M , Matsumoto M , Matsuno A , Muraki A , Nakayama S , Nakazaki N , Shinpo S , Takeuchi C , Wada T , Watanabe A , Yamada M , Yasuda M , Tabata S
Ref : Nature , 408 :820 , 2000
PubMedID: 11130713
Gene_locus related to this paper: arath-MES17 , arath-AT3G12150 , arath-At3g61680 , arath-AT3g62590 , arath-CXE12 , arath-eds1 , arath-SCP25 , arath-F1P2.110 , arath-F1P2.140 , arath-F11F8.28 , arath-F14D17.80 , arath-F16B3.4 , arath-SCP27 , arath-At3g50790 , arath-At3g05600 , arath-PAD4 , arath-At3g51000 , arath-SCP16 , arath-gid1 , arath-GID1B , arath-Q9LUG8 , arath-Q84JS1 , arath-Q9SFF6 , arath-q9m236 , arath-q9sr22 , arath-q9sr23 , arath-SCP7 , arath-SCP14 , arath-SCP15 , arath-SCP17 , arath-SCP36 , arath-SCP37 , arath-SCP39 , arath-SCP40 , arath-SCP49 , arath-T19F11.2

Title : EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases - Falk_1999_Proc.Natl.Acad.Sci.U.S.A_96_3292
Author(s) : Falk A , Feys BJ , Frost LN , Jones JDG , Daniels MJ , Parker JE
Ref : Proceedings of the National Academy of Sciences of the United States of America , 96 :3292 , 1999
PubMedID: 10077677
Gene_locus related to this paper: arath-eds1

Title : Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes - Parker_1996_Plant.Cell_8_2033
Author(s) : Parker JE , Holub EB , Frost LN , Falk A , Gunn ND , Daniels MJ
Ref : Plant Cell , 8 :2033 , 1996
PubMedID: 8953768
Gene_locus related to this paper: arath-eds1 , arath-PAD4