AKOS001963730
W13: BChE IC50 = 0.03 +/- 0.02 microM W13 protected nerve cells from toxicity, hydrogen peroxide (H2O2), and Abeta1-42 stimulation in vitro, antioxidant
General
Type : Indole
Chemical_Nomenclature : N-[N-(2-ethylphenyl)-N'-[2-(1H-indol-3-yl)ethyl]carbamimidoyl]-2-fluorobenzamide
Canonical SMILES : CCC1=CC=CC=C1NC(=NCCC2=CNC3=CC=CC=C32)NC(=O)C4=CC=CC=C4F
InChI : InChI=1S\/C26H25FN4O\/c1-2-18-9-3-7-13-23(18)30-26(31-25(32)21-11-4-6-12-22(21)27)28-16-15-19-17-29-24-14-8-5-10-20(19)24\/h3-14,17,29H,2,15-16H2,1H3,(H2,28,30,31,32)
InChIKey : YYTNLRGJPHXWEF-UHFFFAOYSA-N
Other name(s) : N-[(E)-N'-(2-ethylphenyl)-N'-[2-(1H-indol-3-yl)ethyl]carbamimidoyl]-2-fluorobenzamide
MW : 428.5
Formula : C26H25FN4O
CAS_number :
PubChem : 46283066
UniChem : YYTNLRGJPHXWEF-UHFFFAOYSA-N
Target
Families : AKOS001963730 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of New Butyrylcholinesterase Inhibitors and Evaluation of Their Biological Activity against Alzheimer's Disease - Liao_2026_ACS.Chem.Neurosci__ |
| Author(s) : Liao Q , Wang X , Duan Y , Guo L , He S , Lyu W , Shi J , Fu R , Zhang H , Han Y , Li Q |
| Ref : ACS Chem Neurosci , : , 2026 |
| Abstract : |
| PubMedSearch : Liao_2026_ACS.Chem.Neurosci__ |
| PubMedID: 42335451 |