ARI-4175
pan-DPP inhibitor: IC50 0.0016 microM Dipeptidyl peptidase 4 (human); 0.0019 microM Dipeptidyl peptidase 9 (human); 0.0051 microM Dipeptidyl peptidase 8 (human)
General
Type : Boron compound, Peptide, Pyrrolidine
Chemical_Nomenclature : [(2R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]pyrrolidin-2-yl]boronic acid
Canonical SMILES : B([C@@H]1CCCN1C(=O)[C@H](C(C)(C)C)N)(O)O
InChI : InChI=1S\/C10H21BN2O3\/c1-10(2,3)8(12)9(14)13-6-4-5-7(13)11(15)16\/h7-8,15-16H,4-6,12H2,1-3H3\/t7-,8+\/m0\/s1
InChIKey : YLQGXGBOYJWXBT-JGVFFNPUSA-N
Other name(s) : Tle-boroPro || CHEMBL63406 || BDBM50050520
MW : 228.1
Formula : C10H21BN2O3
CAS_number :
PubChem : 10704521
UniChem : YLQGXGBOYJWXBT-JGVFFNPUSA-N
Target
Families : ARI-4175 ligand of proteins in family
DPP4N_Peptidase_S9
References (6)
| Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656 |
| Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR |
| Ref : Nat Chemical Biology , 10 :656 , 2014 |
| Abstract : |
| PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| PubMedID: 24997602 |
| Gene_locus related to this paper: human-PPME1 |
| Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656 |
| Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR |
| Ref : Nat Chemical Biology , 10 :656 , 2014 |
| Abstract : |
| PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| PubMedID: 24997602 |
| Gene_locus related to this paper: human-PPME1 |
| Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656 |
| Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR |
| Ref : Nat Chemical Biology , 10 :656 , 2014 |
| Abstract : |
| PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| PubMedID: 24997602 |
| Gene_locus related to this paper: human-PPME1 |
| Title : Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides - Coutts_1996_J.Med.Chem_39_2087 |
| Author(s) : Coutts SJ , Kelly TA , Snow RJ , Kennedy CA , Barton RW , Adams J , Krolikowski DA , Freeman DM , Campbell SJ , Ksiazek JF , Bachovchin WW |
| Ref : Journal of Medicinal Chemistry , 39 :2087 , 1996 |
| Abstract : |
| PubMedSearch : Coutts_1996_J.Med.Chem_39_2087 |
| PubMedID: 8642568 |
| Title : Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides - Coutts_1996_J.Med.Chem_39_2087 |
| Author(s) : Coutts SJ , Kelly TA , Snow RJ , Kennedy CA , Barton RW , Adams J , Krolikowski DA , Freeman DM , Campbell SJ , Ksiazek JF , Bachovchin WW |
| Ref : Journal of Medicinal Chemistry , 39 :2087 , 1996 |
| Abstract : |
| PubMedSearch : Coutts_1996_J.Med.Chem_39_2087 |
| PubMedID: 8642568 |
| Title : Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides - Coutts_1996_J.Med.Chem_39_2087 |
| Author(s) : Coutts SJ , Kelly TA , Snow RJ , Kennedy CA , Barton RW , Adams J , Krolikowski DA , Freeman DM , Campbell SJ , Ksiazek JF , Bachovchin WW |
| Ref : Journal of Medicinal Chemistry , 39 :2087 , 1996 |
| Abstract : |
| PubMedSearch : Coutts_1996_J.Med.Chem_39_2087 |
| PubMedID: 8642568 |