| Title : DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation - Hollingsworth_2021_Nature_592_778 |
| Author(s) : Hollingsworth LR , Sharif H , Griswold AR , Fontana P , Mintseris J , Dagbay KB , Paulo JA , Gygi SP , Bachovchin DA , Wu H |
| Ref : Nature , 592 :778 , 2021 |
| Abstract : |
| PubMedSearch : Hollingsworth_2021_Nature_592_778 |
| PubMedID: 33731932 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment - Sharif_2021_Immunity__ |
| Author(s) : Sharif H , Hollingsworth LR , Griswold AR , Hsiao JC , Wang Q , Bachovchin DA , Wu H |
| Ref : Immunity , : , 2021 |
| Abstract : |
| PubMedSearch : Sharif_2021_Immunity__ |
| PubMedID: 34019797 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Structural mechanism of CARD8 regulation by DPP9 - Sharif_2021_Biorxiv__ |
| Author(s) : Sharif H , Hollingsworth LR , Griswold AR , Hsiao JC , Wang QH , Bachovchin DA , Wu H |
| Ref : Biorxiv , : , 2021 |
| Abstract : |
| PubMedSearch : Sharif_2021_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-DPP9 |
| Title : Activation of the CARD8 Inflammasome Requires a Disordered Region - Chui_2020_Cell.Rep_33_108264 |
| Author(s) : Chui AJ , Griswold AR , Taabazuing CY , Orth EL , Gai K , Rao SD , Ball DP , Hsiao JC , Bachovchin DA |
| Ref : Cell Rep , 33 :108264 , 2020 |
| Abstract : |
| PubMedSearch : Chui_2020_Cell.Rep_33_108264 |
| PubMedID: 33053349 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation - Hollingsworth_2020_Biorxiv__ |
| Author(s) : Hollingsworth LR , Sharif H , Griswold AR , Fontana P , Mintseris J , Dagbay KB , Paulo JA , Gygi SP , Bachovchin DA , Wu |
| Ref : Biorxiv , : , 2020 |
| Abstract : |
| PubMedSearch : Hollingsworth_2020_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-DPP9 |
| Title : The NLRP1 and CARD8 inflammasomes - Taabazuing_2020_Immunol.Rev_297_13 |
| Author(s) : Taabazuing CY , Griswold AR , Bachovchin DA |
| Ref : Immunol Rev , 297 :13 , 2020 |
| Abstract : |
| PubMedSearch : Taabazuing_2020_Immunol.Rev_297_13 |
| PubMedID: 32558991 |
| Gene_locus related to this paper: human-DPP9 |
| Title : DPP8\/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes - Johnson_2020_Cell.Death.Dis_11_628 |
| Author(s) : Johnson DC , Okondo MC , Orth EL , Rao SD , Huang HC , Ball DP , Bachovchin DA |
| Ref : Cell Death Dis , 11 :628 , 2020 |
| Abstract : |
| PubMedSearch : Johnson_2020_Cell.Death.Dis_11_628 |
| PubMedID: 32796818 |
| Title : DPP8\/9 inhibitors are universal activators of functional NLRP1 alleles - Gai_2019_Cell.Death.Dis_10_587 |
| Author(s) : Gai K , Okondo MC , Rao SD , Chui AJ , Ball DP , Johnson DC , Bachovchin DA |
| Ref : Cell Death Dis , 10 :587 , 2019 |
| Abstract : |
| PubMedSearch : Gai_2019_Cell.Death.Dis_10_587 |
| PubMedID: 31383852 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : A Chemical Strategy for Protease Substrate Profiling - Griswold_2019_Cell.Chem.Biol_26_901 |
| Author(s) : Griswold AR , Cifani P , Rao SD , Axelrod AJ , Miele MM , Hendrickson RC , Kentsis A , Bachovchin DA |
| Ref : Cell Chemical Biology , 26 :901 , 2019 |
| Abstract : |
| PubMedSearch : Griswold_2019_Cell.Chem.Biol_26_901 |
| PubMedID: 31006619 |
| Title : DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation - Griswold_2019_ACS.Chem.Biol_14_2424 |
| Author(s) : Griswold AR , Ball DP , Bhattacharjee A , Chui AJ , Rao SD , Taabazuing CY , Bachovchin DA |
| Ref : ACS Chemical Biology , 14 :2424 , 2019 |
| Abstract : |
| PubMedSearch : Griswold_2019_ACS.Chem.Biol_14_2424 |
| PubMedID: 31525884 |
| Gene_locus related to this paper: human-DPP9 |
| Title : N-terminal degradation activates the NLRP1B inflammasome - Chui_2019_Science_364_82 |
| Author(s) : Chui AJ , Okondo MC , Rao SD , Gai K , Griswold AR , Johnson DC , Ball DP , Taabazuing CY , Orth EL , Vittimberga BA , Bachovchin DA |
| Ref : Science , 364 :82 , 2019 |
| Abstract : |
| PubMedSearch : Chui_2019_Science_364_82 |
| PubMedID: 30872531 |
| Title : DPP8\/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia - Johnson_2018_Nat.Med_24_1151 |
| Author(s) : Johnson DC , Taabazuing CY , Okondo MC , Chui AJ , Rao SD , Brown FC , Reed C , Peguero E , de Stanchina E , Kentsis A , Bachovchin DA |
| Ref : Nat Med , 24 :1151 , 2018 |
| Abstract : |
| PubMedSearch : Johnson_2018_Nat.Med_24_1151 |
| PubMedID: 29967349 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Inhibition of Dpp8\/9 Activates the Nlrp1b Inflammasome - Okondo_2018_Cell.Chem.Biol_25_262 |
| Author(s) : Okondo MC , Rao SD , Taabazuing CY , Chui AJ , Poplawski SE , Johnson DC , Bachovchin DA |
| Ref : Cell Chemical Biology , 25 :262 , 2018 |
| Abstract : |
| PubMedSearch : Okondo_2018_Cell.Chem.Biol_25_262 |
| PubMedID: 29396289 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages - Taabazuing_2017_Cell.Chem.Biol_24_507 |
| Author(s) : Taabazuing CY , Okondo MC , Bachovchin DA |
| Ref : Cell Chemical Biology , 24 :507 , 2017 |
| Abstract : |
| PubMedSearch : Taabazuing_2017_Cell.Chem.Biol_24_507 |
| PubMedID: 28392147 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis - Okondo_2017_Nat.Chem.Biol_13_46 |
| Author(s) : Okondo MC , Johnson DC , Sridharan R , Go EB , Chui AJ , Wang MS , Poplawski SE , Wu W , Liu Y , Lai JH , Sanford DG , Arciprete MO , Golub TR , Bachovchin WW , Bachovchin DA |
| Ref : Nat Chemical Biology , 13 :46 , 2017 |
| Abstract : |
| PubMedSearch : Okondo_2017_Nat.Chem.Biol_13_46 |
| PubMedID: 27820798 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis - Zhao_2015_ACS.Chem.Biol_10_364 |
| Author(s) : Zhao N , Darby CM , Small J , Bachovchin DA , Jiang X , Burns-Huang KE , Botella H , Ehrt S , Boger DL , Anderson ED , Cravatt BF , Speers AE , Fernandez-Vega V , Hodder PS , Eberhart C , Rosen H , Spicer TP , Nathan CF |
| Ref : ACS Chemical Biology , 10 :364 , 2015 |
| Abstract : |
| PubMedSearch : Zhao_2015_ACS.Chem.Biol_10_364 |
| PubMedID: 25457457 |
| Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656 |
| Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR |
| Ref : Nat Chemical Biology , 10 :656 , 2014 |
| Abstract : |
| PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| PubMedID: 24997602 |
| Gene_locus related to this paper: human-PPME1 |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1) - Adibekian_2013_Probe.Report__3 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : |
| PubMedSearch : Adibekian_2013_Probe.Report__3 |
| PubMedID: 24624465 |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) - Adibekian_2013_Probe.Report__4 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : |
| PubMedSearch : Adibekian_2013_Probe.Report__4 |
| PubMedID: 24624468 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition - Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| Author(s) : Zuhl AM , Mohr JT , Bachovchin DA , Niessen S , Hsu KL , Berlin JM , Dochnahl M , Lopez-Alberca MP , Fu GC , Cravatt BF |
| Ref : J Am Chem Soc , 134 :5068 , 2012 |
| Abstract : |
| PubMedSearch : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| PubMedID: 22400490 |
| Gene_locus related to this paper: human-ABHD10 |
| Title : Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9 - Liu_2012_Chembiochem_13_2082 |
| Author(s) : Liu X , Dix M , Speers AE , Bachovchin DA , Zuhl AM , Cravatt BF , Kodadek TJ |
| Ref : Chembiochem , 13 :2082 , 2012 |
| Abstract : |
| PubMedSearch : Liu_2012_Chembiochem_13_2082 |
| PubMedID: 22907802 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : The pharmacological landscape and therapeutic potential of serine hydrolases - Bachovchin_2012_Nat.Rev.Drug.Discov_11_52 |
| Author(s) : Bachovchin DA , Cravatt BF |
| Ref : Nat Rev Drug Discov , 11 :52 , 2012 |
| Abstract : |
| PubMedSearch : Bachovchin_2012_Nat.Rev.Drug.Discov_11_52 |
| PubMedID: 22212679 |
| Title : Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes - Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder PS , Rosen H , Cravatt BF |
| Ref : J Am Chem Soc , 134 :10345 , 2012 |
| Abstract : |
| PubMedSearch : Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| PubMedID: 22690931 |
| Title : Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors - Adibekian_2011_Nat.Chem.Biol_7_469 |
| Author(s) : Adibekian A , Martin BR , Wang C , Hsu KL , Bachovchin DA , Niessen S , Hoover H , Cravatt BF |
| Ref : Nat Chemical Biology , 7 :469 , 2011 |
| Abstract : |
| PubMedSearch : Adibekian_2011_Nat.Chem.Biol_7_469 |
| PubMedID: 21572424 |
| Title : Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors - Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 |
| Author(s) : Bachovchin DA , Mohr JT , Speers AE , Wang C , Berlin JM , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Schurer SC , Nomura DK , Rosen H , Fu GC , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 108 :6811 , 2011 |
| Abstract : |
| PubMedSearch : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 |
| PubMedID: 21398589 |
| Gene_locus related to this paper: human-PPME1 |
| Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665 |
| Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A |
| Ref : Journal of the American Chemical Society , 133 :11665 , 2011 |
| Abstract : |
| PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665 |
| PubMedID: 21692504 |
| Gene_locus related to this paper: human-PREPL |
| Title : Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1) - Bachovchin_2010_Probe.Report__1 |
| Author(s) : Bachovchin DA , Speers AE , Brown SJ , Spicer TP , Fernandez V , Ferguson J , Mohr JT , Murphy J , Fu GC , Cravatt BF , Hodder PS , Rosen H |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Probe.Report__1 |
| PubMedID: 22834039 |
| Title : Probe Report for PME-1 Inhibitors - Bachovchin_2010_Probe.Report__2 |
| Author(s) : Bachovchin DA , Speers AE , Zuhl AM , Brown SJ , Cravatt BF , Fernandez V , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Probe.Report__2 |
| PubMedID: 21433379 |
| Title : Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| Author(s) : Bachovchin DA , Wolfe MR , Masuda K , Brown SJ , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2254 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| PubMedID: 20207142 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Probe Report for RBBP9 Inhibitors - Probe 2 - Bachovchin_2010_Probe.Report.1__ |
| Author(s) : Bachovchin DA , Speers AE , Brown SJ , Cravatt BF , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Probe.Report.1__ |
| PubMedID: 21433382 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Probe Report for RBBP9 Inhibitors - Probe 1 - Brown_2010_Probe.Report__ |
| Author(s) : Brown SJ , Bachovchin DA , Cravatt BF , Fernandez-Vega V , Spicer T , Mercer BA , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Brown_2010_Probe.Report__ |
| PubMedID: 21433353 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |
| Title : Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes - Bachovchin_2009_Nat.Biotechnol_27_387 |
| Author(s) : Bachovchin DA , Brown SJ , Rosen H , Cravatt BF |
| Ref : Nat Biotechnol , 27 :387 , 2009 |
| Abstract : |
| PubMedSearch : Bachovchin_2009_Nat.Biotechnol_27_387 |
| PubMedID: 19329999 |
| Gene_locus related to this paper: human-ABHD11 |