AZ12756122
exemple 117 from WO2008075070A1, synthesized at AstraZeneca Sulfonamide derivatives for therapeutic use as fatty acid synthase inhibitors
General
Type : Sulfonamide, Piperidine, Cyanide, Sulfur Compound
Chemical_Nomenclature : N-[5-[4-(4-cyanophenyl)piperidine-1-carbonyl]-2,4-dimethylphenyl]propane-1-sulfonamide
Canonical SMILES : CCCS(=O)(=O)NC1=C(C=C(C(=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C)C
InChI : InChI=1S\/C24H29N3O3S\/c1-4-13-31(29,30)26-23-15-22(17(2)14-18(23)3)24(28)27-11-9-21(10-12-27)20-7-5-19(16-25)6-8-20\/h5-8,14-15,21,26H,4,9-13H2,1-3H3
InChIKey : KMMFOIYEUUZOOG-UHFFFAOYSA-N
Other name(s) : SCHEMBL4175642
MW : 439.6
Formula : C24H29N3O3S
CAS_number :
PubChem : 57666876
UniChem : KMMFOIYEUUZOOG-UHFFFAOYSA-N
Target
Families : AZ12756122 ligand of proteins in family
Thioesterase
Protein :
human-FASN
References (2)
| Title : AZ12756122, a novel fatty acid synthase inhibitor, decreases resistance features in EGFR-TKI resistant EGFR-mutated NSCLC cell models - Polonio-Alcala_2022_Biomed.Pharmacother_156_113942 |
| Author(s) : Polonio-Alcala E , Porta R , Ruiz-Martinez S , Vasquez-Dongo C , Relat J , Bosch-Barrera J , Ciurana J , Puig T |
| Ref : Biomed Pharmacother , 156 :113942 , 2022 |
| PubMedID: 36411628 |
| Title : Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity - Morigny_2019_Nat.Metab_1_133 |
| Author(s) : Morigny P , Houssier M , Mairal A , Ghilain C , Mouisel E , Benhamed F , Masri B , Recazens E , Denechaud PD , Tavernier G , Caspar-Bauguil S , Virtue S , Sramkova V , Monbrun L , Mazars A , Zanoun M , Guilmeau S , Barquissau V , Beuzelin D , Bonnel S , Marques M , Monge-Roffarello B , Lefort C , Fielding B , Sulpice T , Astrup A , Payrastre B , Bertrand-Michel J , Meugnier E , Ligat L , Lopez F , Guillou H , Ling C , Holm C , Rabasa-Lhoret R , Saris WHM , Stich V , Arner P , Ryden M , Moro C , Viguerie N , Harms M , Hallen S , Vidal-Puig A , Vidal H , Postic C , Langin D |
| Ref : Nat Metab , 1 :133 , 2019 |
| PubMedID: 32694809 |