human-FASN

Homo sapiens (Human) FAS FASN Fatty acid synthase Thioesterase domain (EC 2.3.1.85)

Comment

previously named human-fas. Only the c-terminal thioesterase module is an alpha\/beta hydrolase. Thioesterase is the last module of Fatty acid synthase. Many inhibitors of FASN used to investigete role of FASN in cancer cells are not inhibitors of the thioesterase domain (TVB-3166 and the related molecule TVB-3664)

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Sequence

Peptide

DGLAQQQTQL NLRSLLVNPE GPTLMRLNSV QSSERPLFLV HPIEGSTTVF HSLASRLSIP TYGLQCTRAA PLDSIHSLAA YYIDCIRQVQ PEGPYRVAGY SYGACVAFEM CSQLQAQQSP APTHNSLFLF DGSPTYVLAY TQSYRAKLTP GCEAEPETEA ICFFVQQFTD MEHNRVLEAL LPLKGLEERV AAAVDLIIKS HQGLDRQELS FAARSFYYKL RAAEQYTPKA KYHGNVMLLR AKTGGTYGQD LGADYNLSQV CDGKVSVHVI EGDHRTLLEG SGLESIISII HSSLAEPRVS VREG

References (14)

Title : Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models - Matsukawa_2023_JCI.Insight_8__e161282
Author(s) : Matsukawa T , Yagi T , Uchida T , Sakai M , Mitsushima M , Naganuma T , Yano H , Inaba Y , Inoue H , Yanagida K , Uematsu M , Nakao K , Nakao H , Aiba A , Nagashima Y , Kubota T , Kubota N , Izumida Y , Yahagi N , Unoki-Kubota H , Kaburagi Y , Asahara SI , Kido Y , Shindou H , Itoh M , Ogawa Y , Minami S , Terauchi Y , Tobe K , Ueki K , Kasuga M , Matsumoto M
Ref : JCI Insight , 8 : , 2023
PubMedID: 37681411
Gene_locus related to this paper: human-FASN , mouse-FASN

Title : Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis - Zhang_2021_Front.Med__
Author(s) : Zhang J , Song Y , Shi Q , Fu L
Ref : Front Med , : , 2021
PubMedID: 33973101
Gene_locus related to this paper: human-FASN , human-MGLL

Title : Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues - Wallace_2018_Nat.Chem.Biol_14_1021
Author(s) : Wallace M , Green CR , Roberts LS , Lee YM , McCarville JL , Sanchez-Gurmaches J , Meurs N , Gengatharan JM , Hover JD , Phillips SA , Ciaraldi TP , Guertin DA , Cabrales P , Ayres JS , Nomura DK , Loomba R , Metallo CM
Ref : Nat Chemical Biology , 14 :1021 , 2018
PubMedID: 30327559
Gene_locus related to this paper: human-FASN

Title : Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis - Park_2015_J.Chem.Inf.Model_55_1914
Author(s) : Park IH , Venable JD , Steckler C , Cellitti SE , Lesley SA , Spraggon G , Brock A
Ref : J Chem Inf Model , 55 :1914 , 2015
PubMedID: 26241692
Gene_locus related to this paper: human-FASN

Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757
Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA
Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011
PubMedID: 21908709
Gene_locus related to this paper: human-FASN

Title : Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat - Pemble_2007_Nat.Struct.Mol.Biol_14_704
Author(s) : Pemble CWt , Johnson LC , Kridel SJ , Lowther WT
Ref : Nat Struct Mol Biol , 14 :704 , 2007
PubMedID: 17618296
Gene_locus related to this paper: human-FASN

Title : Fatty acid synthase inhibitors: new directions for oncology - Kridel_2007_Expert.Opin.Investig.Drugs_16_1817
Author(s) : Kridel SJ , Lowther WT , Pemble CWt
Ref : Expert Opin Investig Drugs , 16 :1817 , 2007
PubMedID: 17970640
Gene_locus related to this paper: human-FASN

Title : Novel antagonists of the thioesterase domain of human fatty acid synthase - Richardson_2007_Mol.Cancer.Ther_6_2120
Author(s) : Richardson RD , Smith JW
Ref : Mol Cancer Ther , 6 :2120 , 2007
PubMedID: 17620441
Gene_locus related to this paper: human-FASN

Title : Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? - Lupu_2006_Curr.Pharm.Biotechnol_7_483
Author(s) : Lupu R , Menendez JA
Ref : Curr Pharm Biotechnol , 7 :483 , 2006
PubMedID: 17168665
Gene_locus related to this paper: human-FASN

Title : Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain - Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567
Author(s) : Chakravarty B , Gu Z , Chirala SS , Wakil SJ , Quiocho FA
Ref : Proc Natl Acad Sci U S A , 101 :15567 , 2004
PubMedID: 15507492
Gene_locus related to this paper: human-FASN

Title : Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity - Kridel_2004_Cancer.Res_64_2070
Author(s) : Kridel SJ , Axelrod F , Rozenkrantz N , Smith JW
Ref : Cancer Research , 64 :2070 , 2004
PubMedID: 15026345
Gene_locus related to this paper: human-FASN

Title : Human fatty acid synthase: properties and molecular cloning. -
Author(s) : Jayakumar A , Tai M-H , Huang W-Y , Al-Feel W , Hsu M , Abu-Elheiga L , Chirala SS , Wakil SJ
Ref : Proceedings of the National Academy of Sciences of the United States of America , 92 :8695 , 1995
PubMedID: 7567999
Gene_locus related to this paper: human-FASN

Title : Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation. -
Author(s) : Semenkovich CF , Coleman T , Fiedorek FTJr
Ref : J Lipid Res , 36 :1507 , 1995
PubMedID: 7595075
Gene_locus related to this paper: human-FASN

Title : Fatty acid synthesis: a potential selective target for antineoplastic therapy. -
Author(s) : Kuhajda FP , Jenner K , Wood FD , Hennigar RA , Jacobs LB , Dick JD , Pasternack GR
Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :6379 , 1994
PubMedID: 8022791
Gene_locus related to this paper: human-FASN