human-FASN
Homo sapiens (Human) FAS FASN Fatty acid synthase Thioesterase domain (EC 2.3.1.85)
Comment
previously named human-fas. Only the c-terminal thioesterase module is an alpha\/beta hydrolase. Thioesterase is the last module of Fatty acid synthase. Many inhibitors of FASN used to investigete role of FASN in cancer cells are not inhibitors of the thioesterase domain (TVB-3166 and the related molecule TVB-3664)
Relationship
Family : Thioesterase
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
1XKT - Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain
2PX6 - Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
3TJM - Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct
4Z49 - Homo Sapiens Fatty Acid Synthetase, Thioesterase Domain at 1.7 Angstroms Resolution
7MHD - Thioesterase domain of human fatty acid synthase (FASN-TE) binding a competitive inhibitor SBP-7635
7MHE - Thioesterase domain of human fatty acid synthase (FASN-TE) binding a competitive inhibitor SBP-7957
9B7Z - Human endogenous FASN with 1,3-DBP - Class 1 focused condensing domain
9B80 - Human endogenous FASN with 1,3-DBP - Class 1 focused modifying domain
No kinetic
No disease
Database
Sequence
Peptide
DGLAQQQTQL NLRSLLVNPE GPTLMRLNSV QSSERPLFLV HPIEGSTTVF HSLASRLSIP TYGLQCTRAA PLDSIHSLAA YYIDCIRQVQ PEGPYRVAGY SYGACVAFEM CSQLQAQQSP APTHNSLFLF DGSPTYVLAY TQSYRAKLTP GCEAEPETEA ICFFVQQFTD MEHNRVLEAL LPLKGLEERV AAAVDLIIKS HQGLDRQELS FAARSFYYKL RAAEQYTPKA KYHGNVMLLR AKTGGTYGQD LGADYNLSQV CDGKVSVHVI EGDHRTLLEG SGLESIISII HSSLAEPRVS VREG
References (14)
| Title : Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models - Matsukawa_2023_JCI.Insight_8__e161282 |
| Author(s) : Matsukawa T , Yagi T , Uchida T , Sakai M , Mitsushima M , Naganuma T , Yano H , Inaba Y , Inoue H , Yanagida K , Uematsu M , Nakao K , Nakao H , Aiba A , Nagashima Y , Kubota T , Kubota N , Izumida Y , Yahagi N , Unoki-Kubota H , Kaburagi Y , Asahara SI , Kido Y , Shindou H , Itoh M , Ogawa Y , Minami S , Terauchi Y , Tobe K , Ueki K , Kasuga M , Matsumoto M |
| Ref : JCI Insight , 8 : , 2023 |
| Abstract : |
| PubMedSearch : Matsukawa_2023_JCI.Insight_8__e161282 |
| PubMedID: 37681411 |
| Gene_locus related to this paper: human-FASN , mouse-FASN |
| Title : Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis - Zhang_2021_Front.Med__ |
| Author(s) : Zhang J , Song Y , Shi Q , Fu L |
| Ref : Front Med , : , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Front.Med__ |
| PubMedID: 33973101 |
| Gene_locus related to this paper: human-FASN , human-MGLL |
| Title : Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues - Wallace_2018_Nat.Chem.Biol_14_1021 |
| Author(s) : Wallace M , Green CR , Roberts LS , Lee YM , McCarville JL , Sanchez-Gurmaches J , Meurs N , Gengatharan JM , Hover JD , Phillips SA , Ciaraldi TP , Guertin DA , Cabrales P , Ayres JS , Nomura DK , Loomba R , Metallo CM |
| Ref : Nat Chemical Biology , 14 :1021 , 2018 |
| Abstract : |
| PubMedSearch : Wallace_2018_Nat.Chem.Biol_14_1021 |
| PubMedID: 30327559 |
| Gene_locus related to this paper: human-FASN |
| Title : Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis - Park_2015_J.Chem.Inf.Model_55_1914 |
| Author(s) : Park IH , Venable JD , Steckler C , Cellitti SE , Lesley SA , Spraggon G , Brock A |
| Ref : J Chem Inf Model , 55 :1914 , 2015 |
| Abstract : |
| PubMedSearch : Park_2015_J.Chem.Inf.Model_55_1914 |
| PubMedID: 26241692 |
| Gene_locus related to this paper: human-FASN |
| Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA |
| Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011 |
| Abstract : |
| PubMedSearch : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedID: 21908709 |
| Gene_locus related to this paper: human-FASN |
| Title : Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat - Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
| Author(s) : Pemble CWt , Johnson LC , Kridel SJ , Lowther WT |
| Ref : Nat Struct Mol Biol , 14 :704 , 2007 |
| Abstract : |
| PubMedSearch : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
| PubMedID: 17618296 |
| Gene_locus related to this paper: human-FASN |
| Title : Fatty acid synthase inhibitors: new directions for oncology - Kridel_2007_Expert.Opin.Investig.Drugs_16_1817 |
| Author(s) : Kridel SJ , Lowther WT , Pemble CWt |
| Ref : Expert Opin Investig Drugs , 16 :1817 , 2007 |
| Abstract : |
| PubMedSearch : Kridel_2007_Expert.Opin.Investig.Drugs_16_1817 |
| PubMedID: 17970640 |
| Gene_locus related to this paper: human-FASN |
| Title : Novel antagonists of the thioesterase domain of human fatty acid synthase - Richardson_2007_Mol.Cancer.Ther_6_2120 |
| Author(s) : Richardson RD , Smith JW |
| Ref : Mol Cancer Ther , 6 :2120 , 2007 |
| Abstract : |
| PubMedSearch : Richardson_2007_Mol.Cancer.Ther_6_2120 |
| PubMedID: 17620441 |
| Gene_locus related to this paper: human-FASN |
| Title : Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? - Lupu_2006_Curr.Pharm.Biotechnol_7_483 |
| Author(s) : Lupu R , Menendez JA |
| Ref : Curr Pharm Biotechnol , 7 :483 , 2006 |
| Abstract : |
| PubMedSearch : Lupu_2006_Curr.Pharm.Biotechnol_7_483 |
| PubMedID: 17168665 |
| Gene_locus related to this paper: human-FASN |
| Title : Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain - Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
| Author(s) : Chakravarty B , Gu Z , Chirala SS , Wakil SJ , Quiocho FA |
| Ref : Proc Natl Acad Sci U S A , 101 :15567 , 2004 |
| Abstract : |
| PubMedSearch : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
| PubMedID: 15507492 |
| Gene_locus related to this paper: human-FASN |
| Title : Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity - Kridel_2004_Cancer.Res_64_2070 |
| Author(s) : Kridel SJ , Axelrod F , Rozenkrantz N , Smith JW |
| Ref : Cancer Research , 64 :2070 , 2004 |
| Abstract : |
| PubMedSearch : Kridel_2004_Cancer.Res_64_2070 |
| PubMedID: 15026345 |
| Gene_locus related to this paper: human-FASN |
| Title : Human fatty acid synthase: properties and molecular cloning. - |
| Author(s) : Jayakumar A , Tai M-H , Huang W-Y , Al-Feel W , Hsu M , Abu-Elheiga L , Chirala SS , Wakil SJ |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 92 :8695 , 1995 |
| PubMedID: 7567999 |
| Gene_locus related to this paper: human-FASN |
| Title : Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation. - |
| Author(s) : Semenkovich CF , Coleman T , Fiedorek FTJr |
| Ref : J Lipid Res , 36 :1507 , 1995 |
| PubMedID: 7595075 |
| Gene_locus related to this paper: human-FASN |
| Title : Fatty acid synthesis: a potential selective target for antineoplastic therapy. - |
| Author(s) : Kuhajda FP , Jenner K , Wood FD , Hennigar RA , Jacobs LB , Dick JD , Pasternack GR |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :6379 , 1994 |
| PubMedID: 8022791 |
| Gene_locus related to this paper: human-FASN |