Ac-Gly-BoroPro
inhibited FAP with a K(i) of 23 +/- 3 nm. 9- to approximately 5400-fold lower than the K(i) values for other prolyl peptidases, including DPP-4, DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase
General
Type : Pyrrolidine, Boron compound
Chemical_Nomenclature : [(2S)-1-(2-acetamidoacetyl)pyrrolidin-2-yl]boronic acid
Canonical SMILES : B([C@H]1CCCN1C(=O)CNC(=O)C)(O)O
InChI : InChI=1S\/C8H15BN2O4\/c1-6(12)10-5-8(13)11-4-2-3-7(11)9(14)15\/h7,14-15H,2-5H2,1H3,(H,10,12)\/t7-\/m1\/s1
InChIKey : UUOZISWTWURDGU-SSDOTTSWSA-N
Other name(s) : CHEMBL4640030 || BDBM50543969
MW : 214.03
Formula : C8H15BN2O4
CAS_number : 886992-99-0
PubChem : 102176419
UniChem : UUOZISWTWURDGU-SSDOTTSWSA-N
Target
Families : Ac-Gly-BoroPro ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-FAP
References (3)
| Title : Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity - Edosada_2006_J.Biol.Chem_281_7437 |
| Author(s) : Edosada CY , Quan C , Wiesmann C , Tran T , Sutherlin D , Reynolds M , Elliott JM , Raab H , Fairbrother W , Wolf BB |
| Ref : Journal of Biological Chemistry , 281 :7437 , 2006 |
| Abstract : |
| PubMedSearch : Edosada_2006_J.Biol.Chem_281_7437 |
| PubMedID: 16410248 |
| Gene_locus related to this paper: human-FAP |
| Title : Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity - Edosada_2006_J.Biol.Chem_281_7437 |
| Author(s) : Edosada CY , Quan C , Wiesmann C , Tran T , Sutherlin D , Reynolds M , Elliott JM , Raab H , Fairbrother W , Wolf BB |
| Ref : Journal of Biological Chemistry , 281 :7437 , 2006 |
| Abstract : |
| PubMedSearch : Edosada_2006_J.Biol.Chem_281_7437 |
| PubMedID: 16410248 |
| Gene_locus related to this paper: human-FAP |
| Title : Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity - Edosada_2006_J.Biol.Chem_281_7437 |
| Author(s) : Edosada CY , Quan C , Wiesmann C , Tran T , Sutherlin D , Reynolds M , Elliott JM , Raab H , Fairbrother W , Wolf BB |
| Ref : Journal of Biological Chemistry , 281 :7437 , 2006 |
| Abstract : |
| PubMedSearch : Edosada_2006_J.Biol.Chem_281_7437 |
| PubMedID: 16410248 |
| Gene_locus related to this paper: human-FAP |