Amberboin
AChE IC50 0.79 +/- 0.03 microM and BChE IC50 0.58 +/- 0.13 microM
General
Type : Octahydroazulenofuran, Natural, Alkaloid
Chemical_Nomenclature : (3aR,9bR)-4-hydroxy-3,9-dimethyl-6-methylidene-3a,4,5,6a,7,9,9a,9b-octahydro-3H-azuleno[4,5-b]furan-2,8-dione
Canonical SMILES : CC1[C@H]2[C@@H](C3C(C(=O)CC3C(=C)CC2O)C)OC1=O
InChI : InChI=1S\/C15H20O4\/c1-6-4-11(17)13-8(3)15(18)19-14(13)12-7(2)10(16)5-9(6)12\/h7-9,11-14,17H,1,4-5H2,2-3H3\/t7?,8?,9?,11?,12?,13-,14-\/m1\/s1
InChIKey : ZAPNUFCAIXITRW-BHYKWGSHSA-N
Other name(s) :
MW : 264.32
Formula : C15H20O4
CAS_number :
PubChem : 137322358
UniChem : ZAPNUFCAIXITRW-BHYKWGSHSA-N
Target
Families : Amberboin ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (2)
| Title : Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer's Disease Therapy - Arya_2021_Biomolecules_11_ |
| Author(s) : Arya A , Chahal R , Rao R , Rahman MH , Kaushik D , Akhtar MF , Saleem A , Khalifa SMA , El-Seedi HR , Kamel M , Albadrani GM , Abdel-Daim MM , Mittal V |
| Ref : Biomolecules , 11 : , 2021 |
| Abstract : |
| PubMedSearch : Arya_2021_Biomolecules_11_ |
| PubMedID: 33669097 |
| Title : Amberboin and lipidiol: X-ray crystalographic data, absolute configuration and inhibition of cholinesterase - Elsebai_2018_Phytochemistry.Letters_27_44 |
| Author(s) : Elsebai MF , Ghabbour HA , Marzouk AM , Salmas RE , Orhan IE , Senol FS |
| Ref : Phytochemistry Letters , 27 :44 , 2018 |
| Abstract : |
| PubMedSearch : Elsebai_2018_Phytochemistry.Letters_27_44 |
| PubMedID: |