Arylidene-hydrazinyl-1,3-thiazole-cpd14
IC50 microM; eeel 0.092 +/- 0.04; horseBChE 7.36 +/- 0.02; horseBACE 7.05 +/- 2.02
General
Type : Thiazole, Sulfur Compound, Hydrazinylidene, Hydrazide, Multitarget, BACE1-inhibitor, Organochlorine
Chemical_Nomenclature : (2Z,3E)-4-(2,6-Dichlorophenyl)-2-(2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazinylidene)but-3-enoic acid
Canonical SMILES : C1(=C(C=CC=C1Cl)Cl)C=CC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C(=O)O
InChI : InChI=1S\/C19H12Cl3N3O2S\/c20-12-6-4-11(5-7-12)17-10-28-19(23-17)25-24-16(18(26)27)9-8-13-14(21)2-1-3-15(13)22\/h1-10H,(H,23,25)(H,26,27)\/b9-8+,24-16-
InChIKey : YQEASJADRXRCRG-UFTOLZQXSA-N
Other name(s) : Compound 14
Target
Families : Arylidene-hydrazinyl-1,3-thiazole-cpd14 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Repurposed Arylidene-hydrazinyl-1,3-thiazoles as Multitarget Anti-Alzheimer's Agents via Combined Computational and Experimental Studies - Drozdowska_2025_ACS.Omega_10_59328 |
| Author(s) : Drozdowska D , Ratkiewicz A , Wrobel-Talalaj A , Parzych C , El-Dershaby HA , Abd El-Razik HA , Soliman FSG , El-Wakil MH |
| Ref : ACS Omega , 10 :59328 , 2025 |
| Abstract : |
| PubMedSearch : Drozdowska_2025_ACS.Omega_10_59328 |
| PubMedID: 41502755 |