Arylidene-hydrazinyl-1,3-thiazole-cpd8
IC50 microM; eeelAChE 0.117 +/- 0.02; horseBChE 6.09 +/- 0.02; horseBACE 6.03 +/- 2.22
General
Type : Thiazole, Sulfur Compound, Hydrazinylidene, Hydrazide, Multitarget, BACE1-inhibitor, Organochlorine
Chemical_Nomenclature : (2Z,3E)-4-(4-Chlorophenyl)-2-(2-(4-(4-bromophenyl)thiazol-2-yl)hydrazinylidene)but-3-enoic acid
Canonical SMILES : C1(=CC=C(C=C1)Cl)C=CC(=NN(C2=NC(=CS2)C3=CC=C(C=C3)Br)[H])C(=O)O[H]
InChI : InChI=1S\/C19H13BrClN3O2S\/c20-14-6-4-13(5-7-14)17-11-27-19(22-17)24-23-16(18(25)26)10-3-12-1-8-15(21)9-2-12\/h1-11H,(H,22,24)(H,25,26)
InChIKey : SIMHBRPJNKXMIX-UHFFFAOYSA-N
Other name(s) : Compound 8
Target
Families : Arylidene-hydrazinyl-1,3-thiazole-cpd8 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Repurposed Arylidene-hydrazinyl-1,3-thiazoles as Multitarget Anti-Alzheimer's Agents via Combined Computational and Experimental Studies - Drozdowska_2025_ACS.Omega_10_59328 |
| Author(s) : Drozdowska D , Ratkiewicz A , Wrobel-Talalaj A , Parzych C , El-Dershaby HA , Abd El-Razik HA , Soliman FSG , El-Wakil MH |
| Ref : ACS Omega , 10 :59328 , 2025 |
| Abstract : |
| PubMedSearch : Drozdowska_2025_ACS.Omega_10_59328 |
| PubMedID: 41502755 |