Azacoelenterazine
Non-oxidizable coelenterazine (CTZ) analogue
General
Chemical_Nomenclature : 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyrazin-3-one
Canonical SMILES : C1=CC=C(C=C1)CC2=NC(=CN3C2=NN(C3=O)CC4=CC=C(C=C4)O)C5=CC=C(C=C5)O
InChI : InChI=1S\/C25H20N4O3\/c30-20-10-6-18(7-11-20)15-29-25(32)28-16-23(19-8-12-21(31)13-9-19)26-22(24(28)27-29)14-17-4-2-1-3-5-17\/h1-13,16,30-31H,14-15H2
InChIKey : FAFQJYQLYIUGAT-UHFFFAOYSA-N
Other name(s) : VK8, azaCTZ
MW : 424.5
Formula : C25H20N4O3
CAS_number :
PubChem : 163321840
UniChem : FAFQJYQLYIUGAT-UHFFFAOYSA-N
Target
Families : Azacoelenterazine ligand of proteins in family
Haloalkane_dehalogenase-HLD2
Protein :
9zzzz-AncHLDRLuc2
renre-luc
9zzzz-AncHLDRLuc
References (3)
| Title : Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues - Gao_2023_ChemCatChem_15_e202300745 |
| Author(s) : Gao T , Damborsky J , Janin YL , Marek M |
| Ref : ChemCatChem , 15 :e202300745 , 2023 |
| PubMedID: |
| Gene_locus related to this paper: renre-luc |
| Title : Catalytic mechanism for Renilla-type luciferases - Schenkmayerova_2023_Nat.Catal_6_23 |
| Author(s) : Schenkmayerova A , Toul M , Pluskal D , Baatallah R , Gagnot G , Pinto GP , Santana VT , Stuchla M , Neugebauer P , Chaiyen P , Damborsky J , Bednar D , Janin YL , Prokop Z , Marek M |
| Ref : Nature Catalysis , 6 :23 , 2023 |
| PubMedID: |
| Gene_locus related to this paper: 9zzzz-AncHLDRLuc2 , renre-luc |
| Title : A catalytic mechanism for Renilla-type bioluminescence - Schenkmayerova_2022_Biorxiv__ |
| Author(s) : Schenkmayerova A , Toul M , Pluskal D , Baatallah R , Gagnot G , Pinto GP , Santana VT , Stuchla M , Neugebauer P , Chaiyen P , Damborsky J , Bednar D , Janin YL , Prokop Z , Marek M |
| Ref : Biorxiv , : , 2022 |
| PubMedID: |
| Gene_locus related to this paper: 9zzzz-AncHLDRLuc2 , renre-luc |