Haloalkane_dehalogenase-HLD2

Relationship

Family: Haloalkane_dehalogenase-HLD2

Block: X

Parent Family: Epoxide-hydrolase_like

Comment

Haloalkane dehalogenases (HLDs) are enzymes that catalyze the cleavage of carbon halogen bonds by a hydrolytic mechanism. The catalytic triad consists of the key nucleophile (Asp) the general base (His) and a catalytic acid (Asp or Glu). HLD where subdivided in three subfamily (Chovancova et al.) according to their substrate specificity and position of active site residues. Class one HLD1 (HLD-I) has catalytic triad Asp-His-Asp and halide-strabilizing residues Trp-Trp. Class two HLDII (HLD-II) has catalytic triad Asp-His-Glu and halide-stabilizing residues Asn-Trp. Class three HLDIII (HLD-III) has catalytic triad Asp-His-Asp and halide-strabilizing residues Asn-Trp. Although the reaction performed is different the Renilla reniformis luciferase belongs to this family. In ESTHER as in HAMAP database class I and III are merged as they are close. Luciferase from Renilla reniformis (RLuc) catalyzes the degradation of coelenterazine in the presence of molecular oxygen, resulting in the product coelenteramide, carbon dioxide, and the desired photon of light (EC 1.13.12.5). This enzyme belongs to the Haloalkane dehalogenase family II with a different catalytic function (EC 3.8.1.5) (this luciferase is different from fireflies luciferases classified as Luciferin 4-monooxygenase; ATP-dependent AMP-binding enzyme family). Reconstruction of an ancestral enzyme shows it has both hydrolase and monooxygenase activities ( Chaloupkova et al.)

Database

Interpro : IPR023594 Haloalkane dehalogenase, subfamily 2

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00561 Abhydrolase_1

Prints : No Print

EC Number : 3.8.1.5

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
1BN6 Rhodococcus haloalkane dehalogenase rhoso-halo1
1BN7 Rhodococcus haloalkane dehalogenase in complex with acetate rhoso-halo1
1CQW Rhodococcus Sp. Haloalcane dehalogenase cocrystal Nai rhoso-halo1
1CV2 Hydrolytic haloalkane dehalogenase Linb from Sphingomonas paucimobilis UT26 at 1.6 A resolution sphpi-linb
1D07 Hydrolytic haloalkane dehalogenase Linb from Sphingomonas paucimobilis Ut26 With 1,3-Propanediol, a product of debromidation of dibrompropane, at 2.0A Resolution sphpi-linb
8J1O Crystal structure of HaloTag complexed with BTTA rhoso-halo1
8B6N X-ray structure of the haloalkane dehalogenase HaloTag7 circular permutated at positions 141-156 (cpHaloTagDelta) rhoso-halo1
8B6O X-ray structure of the haloalkane dehalogenase HaloTag7 circular permutated at positions 141-156 (cpHaloTagDelta) fused to M13 rhoso-halo1
8B6P X-ray structure of the haloalkane dehalogenase HaloTag7 circular permutated at positions 154-156 (cpHaloTag7_154-156) rhoso-halo1
8B6Q X-ray structure of the haloalkane dehalogenase HaloTag7 with an insertion of Calmodulin-M13 fusion at position 154-156 that mimic the structure of CaProLa, an calcium gated protein labeling technology rhoso-halo1
8OE6 Structure of hyperstable haloalkane dehalogenase variant DhaA231 rhoso-halo1
8OE2 Structure of hyperstable haloalkane dehalogenase variant DhaA223 rhoso-halo1
8B5K Structure of haloalkane dehalogenase DmmarA from Mycobacterium marinum at pH 6.5 mycua-a0pum4
8B5O Structure of haloalkane dehalogenase DmmarA from Mycobacterium marinum at pH 5.5 mycua-a0pum4
7NFZ Crystal structure of haloalkane dehalogenase LinB57 mutant (H272F) from Sphingobium japonicum UT26 sphpi-linb
6Y9E Crystal structure of putative ancestral haloalkane dehalogenase AncHLD2 (node 2) 9bact-AncHLD2
6Y9F Crystal structure of putative ancestral haloalkane dehalogenase AncHLD3 (node 3) 9bact-AncHLD3
7PW1 Crystal structure of ancestral haloalkane dehalogenase AncLinB-DmbA 9zzzz-AncLinB
6Y9G Crystal structure of putative ancestral haloalkane dehalogenase AncHLD5 (node 5) 9bact-AncHLD5
6YN2 Crystal structure of Renilla reniformis luciferase variant RLuc8-W121F\/E144Q in complex with a coelenteramide (the postcatalytic enzyme-product complex) renre-luc
6S6E Crystal structure of the engineered ancestor of haloalkane dehalogenases and Renilla luciferase (AncHLD-RLuc I161_F162PinsL) 9zzzz-AncHLDRLuc
7QXQ Coelenteramide-bound Renilla-type luciferase (AncFT) 9zzzz-AncHLDRLuc2
7QXR Azacoelenterazine-bound Renilla-type luciferase (AncFT) 9zzzz-AncHLDRLuc2
6S97 Fragment transplantation onto a hyperstable ancestor of haloalkane dehalogenases and Renilla luciferase (Anc-FT) AncFT 9zzzz-AncHLDRLuc2
7OMR Crystal structure of coelenteramide-bound Renilla reniformis luciferase RLuc8-D162A variant renre-luc
7OMO Crystal structure of coelenteramine-bound Renilla reniformis luciferase RLuc8-D120A variant with fully hydrolyzed product renre-luc
7OMD Crystal structure of azacoelenterazine-bound Renilla reniformis luciferase variant RLuc8-D162A renre-luc
7OME Azacoelenterazine-bound Renilla-type engineered ancestral luciferase variant (AncFT7) 9zzzz-AncFT7
6G75 Crystal structure of the common ancestor of haloalkane dehalogenases and Renilla luciferase (AncHLD-RLuc) 9zzzz-AncHLDRLuc
4BRZ Haloalkane dehalogenase from a Marine Rhodobacteraceae HanR 9rhob-KF032932
4C6H Haloalkane dehalogenase from a Marine Rhodobacteraceae in complex with 1-hexanol 9rhob-KF032932
3WIB Crystal structure of Y109W Mutant Haloalkane Dehalogenase DatA from Agrobacterium tumefaciens C58 agrtu-DHAA
3WI7 Crystal Structure of the Novel Haloalkane Dehalogenase DatA from Agrobacterium tumefaciens C58 agrtu-DHAA
6S42 The double mutant(Ile44Leu+Gln102His) of haloalkane dehalogenase DbeA from Bradyrhizobium elkanii USDA94 with an eliminated halide-binding site brael-e2rv62
6XY9 Crystal structure of haloalkane dehalogenase DbeA-M1 loop variant from Bradyrhizobium elkanii brael-e2rv62
4K2A Crystal structure of haloalkane dehalogenase DbeA from Bradyrhizobium elkani USDA94 brael-e2rv62
7O8B Structure of haloalkane dehalogenase variant DhaA80 from Rhodococcus rhodochrous rhoso-halo1
7O3O Structure of haloalkane dehalogenase mutant DhaA80(T148L, G171Q, A172V, C176F) from Rhodococcus rhodochrous with ionic liquid rhoso-halo1
8SW8 Crystal Structure of HaloTag7 bound to JF669-HaloTag ligand rhoso-halo1
8B6R X-ray structure of the haloalkane dehalogenase HaloTag7 labeled with a chloroalkane Cyanine3 fluorophore substrate rhoso-halo1
8B6S X-ray structure of the haloalkane dehalogenase HaloTag7 fusion to the green fluorescent protein GFP (ChemoG1) labeled with a chloroalkane tetramethylrhodamine fluorophore substrate rhoso-halo1
8B6T X-ray structure of the interface optimized haloalkane dehalogenase HaloTag7 fusion to the green fluorescent protein GFP (ChemoG5-TMR) labeled with a chloroalkane tetramethylrhodamine fluorophore substrate rhoso-halo1
7ZIV X-ray structure of the haloalkane dehalogenase dead variant HaloTag7-D106A bound to a chloroalkane tetramethylrhodamine fluorophore ligand (CA-TMR) rhoso-halo1
7ZIW X-ray structure of the haloalkane dehalogenase HaloTag7 bound to a butyltrifluoromethanesulfonamide tetramethylrhodamine ligand (TMR-T4) rhoso-halo1
7ZIX X-ray structure of the haloalkane dehalogenase HaloTag7 bound to a butylmethanesulfonamide tetramethylrhodamine ligand (TMR-S4) rhoso-halo1
7ZBD Crystal structure of HaloTag complexed with TRaQ-G ligand rhoso-halo1
7ZBB Crystal structure of HaloTag complexed with TRaQ-G-ctrl ligand rhoso-halo1
7ZBA Crystal structure of HaloTag complexed with Me-TRaQ-G ligand rhoso-halo1
7WAM Crystal structure of HaloTag complexed with VL1 rhoso-halo1
7WAN Crystal structure of HaloTag complexed with UL2 rhoso-halo1
7ZJ0 X-ray structure of the haloalkane dehalogenase HaloTag7 bound to a pentylmethanesulfonamide tetramethylrhodamine ligand (TMR-S5) rhoso-halo1
7ZIZ X-ray structure of the dead variant haloalkane dehalogenase HaloTag7-D106A bound to a pentanol tetramethylrhodamine ligand (TMR-Hy5) rhoso-halo1
7ZIY X-ray structure of the haloalkane dehalogenase HaloTag7 bound to a pentyltrifluoromethanesulfonamide tetramethylrhodamine ligand (TMR-T5) rhoso-halo1
7PCW X-ray structure of Haloalkane Halotag7-M175W labeled with chloralkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
7PCX X-ray structure of Haloalkane Halotag7-Q165W labeled with chloralkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
5VNP X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand rhoso-halo1
7OO4 HaloTag Engineering for Enhanced Fluorogenicity and Kinetics with a Styrylpyridine Dye rhoso-halo1
7OND HaloTag Engineering for Enhanced Fluorogenicity and Kinetics with a Styrylpyridine Dye rhoso-halo1
7OIP WITHDRAWN HaloTag Engineering for Enhanced Fluorogenicity with a Simple Channel Dye 1 rhoso-halo1
7OIR WITHDRAWN HaloTag Engineering for Enhanced Fluorogenicity with a Simple Channel Dye 2 rhoso-halo1
6ZVU X-Ray structure of the Haloalkane dehalogenase HOB HaloTag7-P174L labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6ZVV X-Ray structure of the Haloalkane dehalogenase HOB HaloTag7-P174W labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6ZVW X-Ray structure of the Haloalkane dehalogenase HOB HaloTag7-Q165H labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6ZVX X-Ray structure of the Haloalkane dehalogenase HOB HaloTag7-Q165H-P174L labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6ZVY X-Ray structure of the Haloalkane dehalogenase HOB HaloTag7-Q165H-P174R labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6ZCC X-Ray structure of the Haloalkane dehalogenase HOB (HaloTag7-based Oligonucleotide Binder) labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6Y7A X-Ray structure of the Haloalkane dehalogenase HaloTag7 labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate rhoso-halo1
6Y7B X-Ray structure of the Haloalkane dehalogenase HaloTag7 labeled with a chloroalkane-carbopyronine fluorophore substrate rhoso-halo1
6TY7 Crystal structure of haloalkane dehalogenase variant DhaA115 (synthetic construct) domain-swapped dimer type-1 (combined mutations of DhaA101 DhaA112 E20S\/F80R\/C128F\/T148L\/A155P\/A172I\/C176F\/D198W\/V219W\/C262L\/D266F) rhoso-halo1
6XT8 Crystal structure of haloalkane dehalogenase variant DhaA115 (synthetic construct) domain-swapped dimer type-2 (combined mutations of DhaA101 DhaA112 E20S\/F80R\/C128F\/T148L\/A155P\/A172I\/C176F\/D198W\/V219W\/C262L\/D266F) rhoso-halo1
6XTC Crystal structure of haloalkane dehalogenase variant DhaA177 domain-swapped dimer type-3 rhoso-halo1
6SP8 Structure of hyperstable haloalkane dehalogenase variant DhaA115 prepared by the 'soak-and-freeze' method under 150 bar of krypton pressure rhoso-halo1
6SP5 Structure of hyperstable haloalkane dehalogenase variant DhaA115 rhoso-halo1
6U2M Crystal structure of a HaloTag-based calcium indicator, HaloCaMP V2, bound to JF635 rhoso-halo1
6U32 Crystal structure of HaloTag bound to tetramethylrhodamine-HaloTag ligand rhoso-halo1
5Y2Y Crystal structure of HaloTag (M175C) complexed with dansyl-PEG2-HaloTag ligand rhoso-halo1
5Y2X Crystal structure of apo-HaloTag (M175C) rhoso-halo1
5UY1 X-ray crystal structure of apo Halotag (Haloalkane dehalogenase) rhoso-halo1
5UXZ X-ray crystal structure of Halotag (Haloalkane dehalogenase) bound to the P9 benzothiadiazole fluorogenic ligand rhoso-halo1
4KAJ X-Ray Structure of the complex of Haloalkane dehalogenase HaloTag7 with HALTS, Northeast Structural Genomics Consortium (NESG) Target OR151 rhoso-halo1
4KAA Crystal structure of the halotag2 protein at the resolution 2.3A, Northeast Structural Genomics Consortium (NESG) target OR150 rhoso-halo1
4KAC X-Ray Structure of the complex HaloTag2 with HALTS. Northeast Structural Genomics Consortium (NESG) Target OR150. rhoso-halo1
4KAF Crystal Structure of Haloalkane dehalogenase HaloTag7 at the resolution 1.5A, Northeast Structural Genomics Consortium (NESG) Target OR151 rhoso-halo1
4KYV Crystal Structure of dehalogenase HaloTag2 with HALTS at the resolution 1.8A. Northeast Structural Genomics Consortium (NESG) Target OR150 rhoso-halo1
6S06 Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26 sphpi-linb
4WDQ Crystal structure of haloalkane dehalogenase LinB32 mutant (L177W) from Sphingobium japonicum UT26 sphpi-linb
4WDR Crystal structure of haloalkane dehalogenase LinB 140A+143L+177W+211L mutant (LinB86) from Sphingobium japonicum UT26 sphpi-linb
5LKA Crystal structure of haloalkane dehalogenase LinB 140A+143L+177W+211L mutant (LinB86) from Sphingobium japonicum UT26 at 1.3 A resolution sphpi-linb
4H77 Crystal structure of haloalkane dehalogenase LinB from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7D Crystal structure of haloalkane dehalogenase LinB T81A mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7E Crystal structure of haloalkane dehalogenase LinB V112A mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7F Crystal structure of haloalkane dehalogenase LinB V134I mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7H Crystal structure of haloalkane dehalogenase LinB T135A mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7I Crystal structure of haloalkane dehalogenase LinB L138I mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7J Crystal structure of haloalkane dehalogenase LinB H247A mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4H7K Crystal structure of haloalkane dehalogenase LinB I253M mutant from Sphingobium sp. MI1205 sphpi-q6vqx3
4WCV Haloalkane dehalogenase DhaA mutant from Rhodococcus rhodochrous (T148L+G171Q+A172V+C176G) rhoso-halo1
5FLK Structure of haloalkane dehalogenase variant DhaA101 rhoso-halo1
4FWB Structure of Rhodococcus rhodochrous haloalkane dehalogenase mutant DhaA31 in complex with 1, 2, 3 - trichloropropane SUPERSEDES 3RLT rhoso-halo1
3U1T Haloalkane Dehalogenase, DmmA, of marine microbial origin 9cyan-q6dnd9
4F5Z Crystal structure of Rhodococcus rhodochrous haloalkane dehalogenase mutant (L95V, A172V) rhoso-halo1
4F60 Crystal structure of Rhodococcus rhodochrous haloalkane dehalogenase mutant (T148L, G171Q, A172V, C176F) rhoso-halo1
4E46 Structure of Rhodococcus rhodochrous haloalkane dehalogenase DhaA in complex with 2-propanol rhoso-halo1
3SK0 Structure of Rhodococcus rhodochrous haloalkane dehalogenase DhaA mutant DhaA12 rhoso-halo1
3RK4 Structure of Rhodococcus rhodochrous haloalkane dehalogenase mutant DhaA31 rhoso-halo1
3AFI Crystal structure of DBJA (HIS-DBJA) Bradyrhizobium japonicum haloalkane dehalogenase braja-dhaa
3A2L Crystal structure of DBJA (HIS-DBJA) Bradyrhizobium japonicum haloalkane dehalogenase (mutant dbja delta) braja-dhaa
3A2M Crystal structure of DBJA (HIS-DBJA) Bradyrhizobium japonicum haloalkane dehalogenase (WILD TYPE Type I) braja-dhaa
3A2N Crystal structure of DBJA (HIS-DBJA) Bradyrhizobium japonicum haloalkane dehalogenase (Wild Type Type II P21) braja-dhaa
3FWH Structure of haloalkane dehalogenase mutant Dha15 (I135F\/C176Y) from Rhodococcus rhodochrous rhoso-halo1
3G9X Structure of haloalkane dehalogenase DhaA14 mutant I135F from Rhodococcus rhodochrous rhoso-halo1
4HZG Structure of haloalkane dehalogenase DhaA from Rhodococcus rhodochrous rhoso-halo1
3FBW Structure of Rhodococcus rhodochrous haloalkane dehalogenase DhaA mutant C176Y rhoso-halo1
2PSD Crystal Structure of the Luciferase from Renilla Reniformis A55T, C124A, S130A, K136R, A143M, M185V, M253L, S287L (diammonium) renre-luc
2PSE Crystal Structure of the Luciferase from Renilla Reniformis A55T, C124A, S130A, K136R, A143M, M185V, M253L, S287L (KSCN) renre-luc
2PSF Crystal Structure of the Luciferase from Renilla Reniformis A55T, C124A, S130A, K136R, A143M, M185V, M253L, S287L (thiomaltoside) renre-luc
2PSH Crystal Structure of the Luciferase from Renilla Reniformis T2A, K25A, A55T, C124A, S130A, K136R, A143M, M185V, M253L, E277A, S287L (PEG\/isopropanol) renre-luc
2PSJ Crystal Structure of the Luciferase from Renilla Reniformis T2A, A55T, C124A, S130A, K136R, A143M, M185V, M253L, S287L (PEG\/Isopropanol) renre-luc
2V9Z Structure of the Rhodococcus haloalkane dehalogenase mutant with enhanced enantioselectivity rhoso-halo1
2QVB Crystal Structure of Haloalkane Dehalogenase Rv2579 from Mycobacterium tuberculosis myctu-linb
2O2H Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane myctu-linb
2O2I Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol myctu-linb
1G4H Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis complexed with Butan-1-Ol sphpi-linb
1G5F Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis Complexed With 1,2-Dichloroethane sphpi-linb
1G42 Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis Complexed With 1,2-Dichloropropane sphpi-linb
1IZ7 Re-Refinement Of The Structure Of Hydrolytic Haloalkane Dehalogenase Linb From Sphingomonas Paucimobilis Ut26 At 1.6 A Resolution sphpi-linb
1IZ8 Re-Refinement Of The Structure Of Hydrolytic Haloalkane Dehalogenase Linb From Sphingomonas Paucimobilis Ut26 With 1,3-Propanediol, A Product Of Debromidation Of Dibrompropane, At 2.0a Resolution sphpi-linb
1K5P Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis UT26 at 1.8A resolution sphpi-linb
1K6E Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis UT26 at 1.8A resolution with 1,2-propanediol (product of dehalogenation of 1,2-dibromopropane) sphpi-linb
1K63 Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis UT26 at 1.8A resolution with 2-bromo-2-propene-1-ol sphpi-linb
1MJ5 Hydrolytic Haloalkane Dehalogenase Linb from Sphingomonas Paucimobilis UT26 at 1.8A resolution sphpi-linb
2BFN crystal structure of the complex of the haloalkane dehalogenase LinB with the product of dehalogenation reaction 1,2-dichloropropane sphpi-linb

Gene_locus Name Species
9zzzz-AncLinB Ancestral Haloalkane Dehalogenase AncLinB-DmbA synthetic construct
brabe-DbbA Branchiostoma belcheri (Amphioxus) Haloalkane dehalogenase HLD2 DbbA Branchiostoma belcheri
strpu-DspB Strongylocentrotus purpuratus (Purple sea urchin) Haloalkane dehalogenase HLD2 DspB Strongylocentrotus purpuratus
sacko-DskA Saccoglossus kowalevskii Haloalkane dehalogenase HLD2 DskA Saccoglossus kowalevskii
capte-r7umg5 Capitella teleta (Polychaete worm) Haloalkane dehalogenase HLD2 DctA Capitella teleta
9arch-a0a1q9njs0 Candidatus Heimdallarchaeota archaeon LC_3 Haloalkane dehalogenase HLD2 dhaA DchA Candidatus Heimdallarchaeota archaeon LC_3
9noca-DrxA Rhodococcus sp. EPR-157 Haloalkane dehalogenase HLD2 DrxA Rhodococcus sp. EPR-157
sphsx-DspxA unclassified Sphingomonas Haloalkane dehalogenase HLD2 DspxA unclassified Sphingomonas
9noca-k0eup9 Nocardia brasiliensis ATCC 700358 Haloalkane dehalogenase HLD2 DnbA Nocardia brasiliensis ATCC 700358
triha-a0a0f9y4y5 Trichoderma harzianum (Hypocrea lixii) Haloalkane dehalogenase HLD2 DthB Trichoderma harzianum
9rhob-a0a0n7m2p6 Phaeobacter sp. CECT 5382 Haloalkane dehalogenase HLD2 linB DphxA Phaeobacter sp. CECT 5382
triha-a0a0f9x982 Trichoderma harzianum (Hypocrea lixii) Haloalkane dehalogenase HLD2 DthA Trichoderma harzianum
rhile-DrgA Rhizobium leguminosarum Haloalkane dehalogenase HLD2 DrgA Rhizobium leguminosarum
ensad-DeaA Ensifer adhaerens (Sinorhizobium morelense) Haloalkane dehalogenase HLD2 DeaA Ensifer adhaerens
9actn-a0a0c1uk61 marine actinobacterium MedAcidi-G3 Haloalkane dehalogenase HLD2 DmaA marine actinobacterium MedAcidi-G3
9pseu-DathA Amycolatopsis thermoflava Haloalkane dehalogenase HLD2 DathA Amycolatopsis thermoflava
amys7-DaxA Amycolatopsis sp. (strain ATCC 39116 \/ 75iv2) Haloalkane dehalogenase HLD2 DaxA Amycolatopsis sp. ATCC 39116
lenae-DlaA Lentzea aerocolonigenes (Lechevalieria aerocolonigenes) (Saccharothrix aerocolonigenes) Haloalkane dehalogenase HLD2 DlaA Lentzea aerocolonigenes
9rhob-DpxA Pseudovibrio sp. POLY-S9 Haloalkane dehalogenase HLD2 DpxA Pseudovibrio sp. POLY-S9
9actn-a0a1s1sm32 Frankia sp. BMG5.36 Haloalkane dehalogenase HLD2 DfxA Frankia sp. BMG5.36
9bact-AncHLD3 Putative ancestral haloalkane dehalogenase AncHLD3 (node 3) uncultured bacterium
9bact-AncHLD2 Putative ancestral haloalkane dehalogenase AncHLD2 (node 2) uncultured bacterium
9bact-AncHLD5 Putative ancestral haloalkane dehalogenase AncHLD5 (node 5) uncultured bacterium
9zzzz-AncFT7 Synthetic construct of Renilla-type engineered ancestral luciferase variant (AncFT7) synthetic construct
9zzzz-AncHLDRLuc2 Synthetic construct of the common ancestor of haloalkane dehalogenases and Renilla luciferase with fragment transplabntation (Anc-FT) AncFT synthetic construct
9zzzz-AncHLDRLuc Synthetic construct of the common ancestor of haloalkane dehalogenases and Renilla luciferase synthetic construct
9rhob-KF032932 Rhodobacteraceae bacterium Haloalkane_dehalogenase HanR Rhodobacteraceae bacterium UDC319
9bact-b4dav5 Chthoniobacter flavus Ellin428 Haloalkane dehalogenase Chthoniobacter flavus Ellin428
9bact-q6sht4 uncultured bacterium 311 haloalkane dehalogenase HLD2 DmbaA uncultured bacterium 311
9burk-b5whg4 Burkholderia sp. H160 Haloalkane dehalogenase Burkholderia sp. H160
9cyan-q6dnd9 Lyngbya majuscula curN, DmmA, a haloalkane dehalogenase Lyngbya majuscula
9rhob-a3sf89 Sulfitobacter sp. EE-36\; Sulfitobacter pontiacus\; (1-chlorohexanehalidohydrolase) Haloalkane dehalogenase 2 DhaA DspoA Sulfitobacter sp. EE-36
9rhob-a4etx5 Roseobacter sp. SK209-2-6 Haloalkane dehalogenase Roseobacter sp. SK209-2-6
agrtu-DHAA Agrobacterium tumefaciens, Agrobacterium radiobacter, haloalkane dehalogenase DatA Agrobacterium tumefaciens
brael-e2rv62 Bradyrhizobium elkanii haloalkane dehalogenase (EC 3.8.1.5) DbeA Bradyrhizobium elkanii
brafl-c3xxt9 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
braja-dhaa Bradyrhizobium japonicum\; Bradyrhizobium diazoefficiens, haloalkane dehalogenase (EC 3.8.1.5) DhaA DbjA Bradyrhizobium japonicum
deidv-c1cwe6 Deinococcus deserti (strain VCD115 \/ DSM 17065 \/ LMG 22923) Haloalkane dehalogenase Deinococcus deserti
desps-q6ajw5 Desulfotalea psychrophila related to haloalkane dehalogenase HLDIII DdpA Desulfotalea psychrophila
geosf-b9m8q3 Geobacter sp. (strain FRC-32) Alpha\/beta hydrolase fold protein Geobacter sp.
rhilo-dhaa Mesorhizobium loti (Rhizobium loti), Mesorhizobium huakuii DHAA mlr5354 haloalkane dehalogenase Mesorhizobium loti
mycmm-b2hjb4 Mycobacterium marinum, Mycobacterium liflandii, Haloalkane dehalogenase 2 DhaA_1 DmmarB Mycobacterium marinum
mycsm-Q938B4 Mycobacterium smegmatis putative linb haloalkane dehalogenase (fragment) Mycobacterium smegmatis
myctu-linb Mycobacterium tuberculosis, Mycobacterium bovis, DHAA linb DhaA dmbA DmbA Rv2296 haloalkane dehalogenase (EC 3.8.1.5) Mycobacterium tuberculosis
mycua-a0pum4 Mycobacterium ulcerans (strain Agy99) Mycobacterium marinum (strain ATCC BAA-535 \/ M) Haloalkane dehalogenase 2 DhaA DmmarA DmuA Mycobacterium ulcerans
renmu-Q9BLZ3 Renilla muelleri epoxide hydrolase (EC 3.3.2.3) Renilla muelleri
renre-luc Renilla reniformis luciferase , luciferin 2-monooxygenase Renilla reniformis
rhoso-halo1 Rhodococcus rhodochrous (Pseudomonas pavonaceae), Rhodococcus sp., Mycobacterium sp haloalkane dehalogenase (EC 3.8.1.5) DhaA HaloTag (hyperstable variant DhaA115) Rhodococcus rhodochrous
sphpi-linb Sphingomonas paucimobilis (Pseudomonas paucimobilis)\; Sphingomonas sp., Sphingobium (japonicum ummariense indicum), Pseudomonas aeruginosa, LinB Sphingomonas paucimobilis
sphpi-q6vqx3 Sphingomonas paucimobilis (Pseudomonas paucimobilis)\; Sphingobium sp., Sphingobium indicum\; Haloalkane dehalogenase linB gene Sphingomonas paucimobilis
strpu-h3hrw2 Strongylocentrotus purpuratus (purple sea urchin) Haloalkane_dehalogenase Strongylocentrotus purpuratus
triad-b3s949 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
triad-b3s950 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
9chlr-d6tri7 Ktedonobacter racemifer DSM 44963 Haloalkane dehalogenase Ktedonobacter racemifer DSM 44963
9chlr-d6tuz4 Ktedonobacter racemifer DSM 44963 Haloalkane dehalogenase Ktedonobacter racemifer DSM 44963
mescw-e8t767 Mesorhizobium ciceri bv. biserrulae (strain HAMBI 2942 \/ LMG 23838 \/ WSM1271) Haloalkane dehalogenase Mesorhizobium ciceri bv. biserrulae
brajp-g7dmu1 Bradyrhizobium japonicum Haloalkane dehalogenase Bradyrhizobium japonicum USDA 6
brajp-g7dnh7 Bradyrhizobium japonicum USDA 6 Haloalkane dehalogenase Bradyrhizobium japonicum USDA 6
hypvg-g9my22 Hypocrea virens (strain Gv29-8 \/ FGSC 10586) (Gliocladium virens)(Trichoderma virens) Uncharacterized protein Hypocrea virens
hypai-g9p2e2 Hypocrea atroviridis (strain ATCC 20476 \/ IMI 206040) (Trichoderma atroviride) Putative Haloalkane dehalogenase Hypocrea atroviridis
9brad-h0tue9 Bradyrhizobium sp. STM 3843 Haloalkane dehalogenase Bradyrhizobium sp. STM 3843
9brad-i2qj82 Bradyrhizobium sp. WSM1253 Haloalkane dehalogenase Bradyrhizobium sp. WSM1253
9rhiz-j2kud1 Rhizobium sp. CF142 Haloalkane dehalogenase Rhizobium sp. CF142
mycsm-l0iu38 Mycobacterium smegmatis JS623 Haloalkane dehalogenase Mycobacterium smegmatis JS623
myxsd-l7uf81 Myxococcus stipitatus (strain DSM 14675 \/ JCM 12634 \/ Mx s8) Haloalkane dehalogenase Myxococcus stipitatus
9brad-u1imq3 Bradyrhizobium sp. DFCI-1 Haloalkane dehalogenase Bradyrhizobium sp. DFCI-1
9bact-v5llz5 uncultured bacterium Haloalkane dehalogenase Cluster C eHLD-C uncultured bacterium
mycne-v5x835 Mycobacterium neoaurum VKM Ac-1815D Haloalkane dehalogenase Mycobacterium neoaurum VKM Ac-1815D
9rhiz-v7fq40 Mesorhizobium sp. LSHC420B00 Haloalkane dehalogenase Mesorhizobium sp. LSHC420B00
9delt-w4lkq9 Candidatus Entotheonella sp. Haloalkane dehalogenase Candidatus Entotheonella sp. TSY1
9burk-w4p0d0 Burkholderia caribensis MBA4 Haloalkane dehalogenase Burkholderia caribensis MBA4
9pseu-w7svw4 Kutzneria sp. 744 Haloalkane dehalogenase Kutzneria sp. 744

Substrate Chemical Nomenclature Proteins
Mustard-gas 1-chloro-2-(2-chloroethylsulfanyl)ethane xanau-halo1
1,3,4,6-Tetrachloro-1,4-cyclohexadiene 1,3,4,6-tetrachlorocyclohexa-1,4-diene myctu-linb    sphpi-linb
Lindane 1,2,3,4,5,6-hexachlorocyclohexane myctu-linb    sphpi-linb    sphpi-q6vqx3
Coelenterazine N-[2-benzyl-6-(4-oxocyclohexa-2,5-dien-1-ylidene)-1H-pyrazin-3-yl]-2-(4-hydroxyphenyl)acetamide renre-luc    9zzzz-AncHLDRLuc
1-Chlorobutane 1-chlorobutane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Chlorohexane 1-chlorohexane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Bromobutane 1-bromobutane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Iodopropane 1-iodopropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Iodohexane 1-iodohexane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Iodobutane 1-iodobutane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,3-dichloropropane 1,3-dichloropropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,5-dichloropentane 1,5-dichloropentane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Bromo-3-Chloropropane 1-bromo-3-chloropropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,3-diiodopropane 1,3-diiodopropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
2-Iodobutane 2-iodobutane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
2-Bromo-1-Chloropropane 2-bromo-1-chloropropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Chloro-2-(2-chloroethoxy)ethane 1-chloro-2-(2-chloroethoxy)ethane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
Chlorocyclohexane chlorocyclohexane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
Bromocyclohexane bromocyclohexane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
(Bromomethyl)cylcohexane bromomethylcyclohexane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-Bromo-2-chloroethane 1-bromo-2-chloroethane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
Chlorocyclopentane chlorocyclopentane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
4-Bromobutanenitrile 4-bromobutanenitrile agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,2,3-Tribromopropane 1,2,3-tribromopropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,2-Dibromo-3-Chloropropane 1,2-dibromo-3-chloropropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
3-Chloro-2-methylprop-1-ene 3-chloro-2-methylprop-1-ene agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
2,3-Dichloroprop-1-ene 2,3-dichloroprop-1-ene agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
2,3-dibromopropene 2,3-dibromoprop-1-ene sphpi-linb
1,2,3-trichloropropane 1,2,3-trichloropropane braja-dhaa    rhoso-halo1
1,2-dichloropropane (2S)-2,3-dichloropropan-1-ol sphpi-linb    braja-dhaa
1,2-dibromopropane 1,2-dibromopropane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1-bromohexane 1-bromohexane 9rhob-KF032932    agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,3-dibromopropane 1,3-dibromopropane myctu-linb    agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,2-dibromoethane 1,2-dibromoethane agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-linb    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    sphpi-linb    xanau-halo1
1,2-dichloroethane 1,2-dichloroethane sphpi-linb    agrtu-DHAA    brael-e2rv62    braja-dhaa    myctu-Rv1833c    rhoba-DHLA    rhoso-halo1    xanau-halo1

Inhibitor Chemical Nomenclature Proteins
Chloroalkane-Cyanine3-fluorophore ~{N}-[2-[2-(6-chloranylhexoxy)ethoxy]ethyl]-6-[3,3-dimethyl-2-[(~{E})-3-(1,3,3-trimethylindol-2-ylidene)prop-1-enyl]indol-1-ium-1-yl]hexanamide rhoso-halo1
TMR-S4 [9-[2-carboxy-5-[2-[2-[4-(methylsulfonylamino)butoxy]ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium rhoso-halo1
TMR-T4 [9-[2-carboxy-5-[2-[2-[4-(trifluoromethylsulfonylamino)butoxy]ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium rhoso-halo1
TMR-S5 [9-[2-carboxy-5-[2-[2-[5-(methylsulfonylamino)pentoxy]ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium rhoso-halo1
TMR-Hy5 [9-[2-carboxy-5-[2-[2-(5-oxidanylpentoxy)ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium rhoso-halo1
TMR-T5 [9-[2-carboxy-5-[2-[2-[5-(trifluoromethylsulfonylamino)pentoxy]ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium rhoso-halo1
HyT13 2-(1-adamantyl)-N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]acetamide rhoso-halo1
Azacoelenterazine 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyrazin-3-one 9zzzz-AncHLDRLuc2    renre-luc    9zzzz-AncHLDRLuc
TRaQ-G-ILQ (10~{R})-7-azanyl-~{N}-[2-[2-(6-chloranylhexoxy)ethoxy]ethyl]-2'-cyano-5,5-dimethyl-3-(methylamino)-1'-oxidanylidene-spiro[benzo[b][1]benzosiline-10,3'-isoindole]-5'-carboxamide rhoso-halo1
TRaQ-G-ILU [7-azanyl-10-[5-[2-[2-(6-chloranylhexoxy)ethoxy]ethylcarbamoyl]-2-(cyanocarbamoyl)phenyl]-5,5-dimethyl-benzo[b][1]benzosilin-3-ylidene]-methyl-azanium rhoso-halo1
TRaQ-G-ctrl (E)-[7-azanyl-10-[2-carboxy-5-[2-[2-(6-chloranylhexoxy)ethoxy]ethylcarbamoyl]phenyl]-5,5-dimethyl-benzo[b][1]benzosilin-3-ylidene]-methyl-azanium rhoso-halo1
Me-TRaQ-G 4-(7-azanyl-5,5-dimethyl-3-methylimino-benzo[b][1]benzosilin-10-yl)-~{N}-[2-[2-(6-chloranylhexoxy)ethoxy]ethyl]-3-methyl-benzamide rhoso-halo1
VL1-8MH 3-[6-(2-azanylhydrazinyl)-1,3-bis(oxidanylidene)benzo[de]isoquinolin-2-yl]-N-[2-(2-hexoxyethoxy)ethyl]propanamide rhoso-halo1
UL2-8MS (R)-[4-(2-azanylhydrazinyl)phenyl]-[2-[2-(2-hexoxyethoxy)ethoxy]ethylamino]methanol rhoso-halo1
P1-benzoxadiazole-fluorogenic-ligand N-[2-(2-hexoxyethoxy)ethyl]-2-[methyl-[[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl]amino]acetamide rhoso-halo1
VF2-Styrylpyridine-Dye 4-[2-[1-(7-chloroheptyl)pyridin-1-ium-4-yl]ethenyl]-N,N-dimethylaniline rhoso-halo1
Coelenteramine 4-(5-amino-6-benzylpyrazin-2-yl)phenol renre-luc
Coelenteramide N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)acetamide renre-luc
Chloroalkane-carbopyronine-fluorophore [10-[2-carboxy-5-[2-[2-(6-chlorohexoxy)ethoxy]ethylcarbamoyl]phenyl]-7-(dimethylamino)-9,9-dimethylanthracen-2-ylidene]-dimethylazanium rhoso-halo1
Chloroalkane-tetramethylrhodamine-fluorophore [9-[2-carboxy-5-[2-[2-(6-chlorohexoxy)ethoxy]ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium rhoso-halo1
tetramethylrhodamine-HaloTag-ligand [9-[2-carboxy-5-[2-(2-hexoxyethoxy)ethylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium rhoso-halo1
JF635i rhoso-halo1
JF635 N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]-3',7'-bis(3-fluoroazetidin-1-yl)-5',5'-dimethyl-1-oxospiro[2-benzofuran-3,10'-benzo[b][1]benzosiline]-5-carboxamide rhoso-halo1
CHES 2-(cyclohexylamino)ethanesulfonic acid agrtu-DHAA
dansyl-PEG2-HaloTag 5-(dimethylamino)-~{N}-[2-(2-hexoxyethoxy)ethyl]naphthalene-1-sulfonamide rhoso-halo1
P9-benzothiadiazole 2-[[7-(dimethylamino)-2,1,3-benzothiadiazol-4-yl]sulfonyl-methylamino]-N-(6-hydroxyhexyl)acetamide rhoso-halo1
HALSTS-1Q9 N-[(2-ethoxy-3,5-dimethylphenyl)methyl]-2H-tetrazol-5-amine rhoso-halo1
HALSTS1 N-[(3,5-dichloro-2-ethoxyphenyl)methyl]-2H-tetrazol-5-amine rhoso-halo1
Butan-1-Ol butan-1-ol
Benzoic-acid benzoic acid sorbi-hnl    strau-cpoT    psefl-cumD    rhosm-cocE    rhoso-halo1    idesa-mheth    hevbr-hnl

References (26)

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Gene_locus related to this paper: 9zzzz-AncHLDRLuc2 , 9zzzz-AncHLDRLuc , renre-luc

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Gene_locus related to this paper: 9cyan-q6dnd9

Title : A puzzling homology: a brittle star using a putative cnidarian-type luciferase for bioluminescence - Delroisse_2017_Open.Biol_7_
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Gene_locus related to this paper: rhoso-halo1

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Gene_locus related to this paper: rhoso-halo1

Title : Crystal Structure and Site-Directed Mutagenesis Analyses of Haloalkane Dehalogenase LinB from Sphingobium sp. Strain MI1205 - Okai_2013_J.Bacteriol_195_2642
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Gene_locus related to this paper: sphpi-q6vqx3

Title : Structure and activity of DmmA, a marine haloalkane dehalogenase - Gehret_2012_Protein.Sci_21_239
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Gene_locus related to this paper: 9cyan-q6dnd9

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Author(s) : Koudelakova T , Chovancova E , Brezovsky J , Monincova M , Fortova A , Jarkovsky J , Damborsky J
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Abstract :
PubMedSearch : Koudelakova_2011_Biochem.J_435_345
PubMedID: 21294712
Gene_locus related to this paper: agrtu-DHAA , brael-e2rv62 , braja-dhaa , myctu-linb , myctu-Rv1833c , rhoba-DHLA , rhoso-halo1 , sphpi-linb , xanau-halo1

Title : Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering -
Author(s) : Prokop Z , Sato Y , Brezovsky J , Mozga T , Chaloupkova R , Koudelakova T , Jerabek P , Stepankova V , Natsume R , van Leeuwen JG , Janssen DB , Florian J , Nagata Y , Senda T , Damborsky J
Ref : Angew Chem Int Ed Engl , 49 :6111 , 2010
PubMedID: 20645368
Gene_locus related to this paper: braja-dhaa

Title : Pathways and mechanisms for product release in the engineered haloalkane dehalogenases explored using classical and random acceleration molecular dynamics simulations - Klvana_2009_J.Mol.Biol_392_1339
Author(s) : Klvana M , Pavlova M , Koudelakova T , Chaloupkova R , Dvorak P , Prokop Z , Stsiapanava A , Kuty M , Kuta-Smatanova I , Dohnalek J , Kulhanek P , Wade RC , Damborsky J
Ref : Journal of Molecular Biology , 392 :1339 , 2009
Abstract :
PubMedSearch : Klvana_2009_J.Mol.Biol_392_1339
PubMedID: 19577578
Gene_locus related to this paper: rhoso-halo1

Title : X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579 - Mazumdar_2008_Biochim.Biophys.Acta_1784_351
Author(s) : Mazumdar PA , Hulecki JC , Cherney MM , Garen CR , James MN
Ref : Biochimica & Biophysica Acta , 1784 :351 , 2008
Abstract :
PubMedSearch : Mazumdar_2008_Biochim.Biophys.Acta_1784_351
PubMedID: 18062934
Gene_locus related to this paper: myctu-linb

Title : Crystal structures of the luciferase and green fluorescent protein from Renilla reniformis - Loening_2007_J.Mol.Biol_374_1017
Author(s) : Loening AM , Fenn TD , Gambhir SS
Ref : Journal of Molecular Biology , 374 :1017 , 2007
Abstract :
PubMedSearch : Loening_2007_J.Mol.Biol_374_1017
PubMedID: 17980388
Gene_locus related to this paper: renre-luc

Title : Phylogenetic analysis of haloalkane dehalogenases - Chovancova_2007_Proteins_67_305
Author(s) : Chovancova E , Kosinski J , Bujnicki JM , Damborsky J
Ref : Proteins , 67 :305 , 2007
Abstract :
PubMedSearch : Chovancova_2007_Proteins_67_305
PubMedID: 17295320

Title : Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry - Monincova_2007_Appl.Environ.Microbiol_73_2005
Author(s) : Monincova M , Prokop Z , Vevodova J , Nagata Y , Damborsky J
Ref : Applied Environmental Microbiology , 73 :2005 , 2007
Abstract :
PubMedSearch : Monincova_2007_Appl.Environ.Microbiol_73_2005
PubMedID: 17259360
Gene_locus related to this paper: sphpi-linb

Title : Crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A resolution: dynamics of catalytic residues - Oakley_2004_Biochemistry_43_870
Author(s) : Oakley AJ , Klvana M , Otyepka M , Nagata Y , Wilce MC , Damborsky J
Ref : Biochemistry , 43 :870 , 2004
Abstract :
PubMedSearch : Oakley_2004_Biochemistry_43_870
PubMedID: 14744129
Gene_locus related to this paper: sphpi-linb

Title : Evolving haloalkane dehalogenases - Janssen_2004_Curr.Opin.Chem.Biol_8_150
Author(s) : Janssen DB
Ref : Curr Opin Chemical Biology , 8 :150 , 2004
Abstract :
PubMedSearch : Janssen_2004_Curr.Opin.Chem.Biol_8_150
PubMedID: 15062775

Title : Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates - Streltsov_2003_Biochemistry_42_10104
Author(s) : Streltsov VA , Prokop Z , Damborsky J , Nagata Y , Oakley A , Wilce MC
Ref : Biochemistry , 42 :10104 , 2003
Abstract :
PubMedSearch : Streltsov_2003_Biochemistry_42_10104
PubMedID: 12939138
Gene_locus related to this paper: sphpi-linb

Title : Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition - Oakley_2002_Biochemistry_41_4847
Author(s) : Oakley AJ , Prokop Z , Bohac M , Kmunicek J , Jedlicka T , Monincova M , Kuta-Smatanova I , Nagata Y , Damborsky J , Wilce MC
Ref : Biochemistry , 41 :4847 , 2002
Abstract :
PubMedSearch : Oakley_2002_Biochemistry_41_4847
PubMedID: 11939779
Gene_locus related to this paper: sphpi-linb

Title : Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 - Marek_2000_Biochemistry_39_14082
Author(s) : Marek J , Vevodova J , Smatanova IK , Nagata Y , Svensson LA , Newman J , Takagi M , Damborsky J
Ref : Biochemistry , 39 :14082 , 2000
Abstract :
PubMedSearch : Marek_2000_Biochemistry_39_14082
PubMedID: 11087355
Gene_locus related to this paper: sphpi-linb

Title : Haloalkane dehalogenases: structure of a Rhodococcus enzyme - Newman_1999_Biochemistry_38_16105
Author(s) : Newman J , Peat TS , Richard R , Kan L , Swanson PE , Affholter JA , Holmes IH , Schindler JF , Unkefer CJ , Terwilliger TC
Ref : Biochemistry , 38 :16105 , 1999
Abstract :
PubMedSearch : Newman_1999_Biochemistry_38_16105
PubMedID: 10587433
Gene_locus related to this paper: rhoso-halo1

Title : Repositioning the catalytic triad aspartic acid of haloalkane dehalogenase: effects on stability, kinetics, and structure - Krooshof_1997_Biochemistry_36_9571
Author(s) : Krooshof GH , Kwant EM , Damborsky J , Koca J , Janssen DB
Ref : Biochemistry , 36 :9571 , 1997
Abstract :
PubMedSearch : Krooshof_1997_Biochemistry_36_9571
PubMedID: 9236003