Benzothiazol-Phenyl-Piperazine-Pyridine-Cpd18
benzothiazolium fluorophore with a bifunctional electron-donating N-aryl piperazine. AChE IC50 = 0.172 +/- 0.011 microM) and butyrylcholinesterase; BuChE IC50 = 1.376 +/- 0.141 microM
General
Type : Benzothiazol, Sulfur Compound, Piperazine, Pyridine, Fluorescent Probe
Chemical_Nomenclature : 3-ethyl-1,3-benzothiazol-but-2-en-[4-(4-pyridin-2-ylpiperazin-1-yl)phenyl]
Canonical SMILES : C1=CC=C2C(=C1)[N+](=C(S2)C=CC3=CC=C(C=C3)N4CCN(CC4)C5=NC=CC=C5)CC.[I-]
InChI : InChI=1S\/C26H27N4S.HI\/c1-2-30-23-7-3-4-8-24(23)31-26(30)15-12-21-10-13-22(14-11-21)28-17-19-29(20-18-28)25-9-5-6-16-27-25\;\/h3-16H,2,17-20H2,1H3\;1H\/q+1\;\/p-1
InChIKey : GMIJCAHWCQUAIR-UHFFFAOYSA-M
Other name(s) : Compound 18
Target
Families : Benzothiazol-Phenyl-Piperazine-Pyridine-Cpd18 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Development of Donor-Acceptor Architecture-Based Potential Theranostic Fluorescent Probes for Alzheimer's Disease - Bajad_2025_ACS.Chem.Neurosci__ |
| Author(s) : Bajad NG , A GT , Sharma K , Tapadia MG , Kumar A , Krishnamurthy S , Singh SK |
| Ref : ACS Chem Neurosci , : , 2025 |
| Abstract : |
| PubMedSearch : Bajad_2025_ACS.Chem.Neurosci__ |
| PubMedID: 40107858 |