Benzothiazol-piperidin-ethoxy-chromen-Cpd13a
13a AChE IC50 1.0 +/- 0.1 nM; BuChE IC50 1212.5 +/- 144.0 nM
General
Type : Piperidine, Coumarin, Chromen, Thiazole, Benzothiazol, Sulfur Compound
Chemical_Nomenclature : 3-(benzo[d]thiazol-2-yl)-7-(2-(piperidin-1-yl)ethoxy)-2H-chromen-2-one
Canonical SMILES : C1CCN(CC1)CCOC2=CC=C3C(=C2)OC(C(=C3)C4=NC5=C(S4)C=CC=C5)=O
InChI : InChI=1S\/C23H22N2O3S\/c26-23-18(22-24-19-6-2-3-7-21(19)29-22)14-16-8-9-17(15-20(16)28-23)27-13-12-25-10-4-1-5-11-25\/h2-3,6-9,14-15H,1,4-5,10-13H2
InChIKey : HXLVGKSKRFOUSI-UHFFFAOYSA-N
Other name(s) : Compound 13a
Target
Families : Benzothiazol-piperidin-ethoxy-chromen-Cpd13a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Dual inhibition of AChE and BuChE by coumarin-benzothiazole hybrids: potent candidates unveiled through innovative screening and docking studies - Gouvea_2026_Bioorg.Chem_176_109838 |
| Author(s) : Gouvea RG , Bezerra ES , Amaral LG , da Conceicao RA , Pauli FP , Coutinho MS , Amaral AP , De Oliveira PCO , da Silva FC , Teles de Souza AM , de Moraes MC , Forezi L |
| Ref : Bioorg Chem , 176 :109838 , 2026 |
| Abstract : |
| PubMedSearch : Gouvea_2026_Bioorg.Chem_176_109838 |
| PubMedID: 41965189 |