Biphenyl-pyrazino-indol-one-Cpd16g
IC50 AChE 6.95 +/- 0.08 NM; BChE 27.18 +/- 3.53 nM
General
Type : Indole
Chemical_Nomenclature : 3-([1,1-biphenyl]-4-yl)pyrazino[1,2-a]indol-1(2H)-one
Canonical SMILES : [N]12C=C(NC(C1=CC3=CC=CC=C23)=O)C4=CC=C(C=C4)C5=CC=CC=C5
InChI : InChI=1S\/C23H16N2O\/c26-23-22-14-19-8-4-5-9-21(19)25(22)15-20(24-23)18-12-10-17(11-13-18)16-6-2-1-3-7-16\/h1-15H,(H,24,26)
InChIKey : PYBWZLXHSZFLLG-UHFFFAOYSA-N
Other name(s) : compound 16g
Target
Families : Biphenyl-pyrazino-indol-one-Cpd16g ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Synthesis of novel pyrazino[1,2-a]indol-1(2H)-one derivatives as potent cholinesterase inhibitors and their in vitro and in silico evaluations - Kuzu_2025_Arch.Biochem.Biophys__110504 |
| Author(s) : Kuzu B , Demir Y |
| Ref : Archives of Biochemistry & Biophysics , :110504 , 2025 |
| Abstract : |
| PubMedSearch : Kuzu_2025_Arch.Biochem.Biophys__110504 |
| PubMedID: 40505851 |