Bischlorobenzyl-hydroxypiperazine-carboxamide-Cpd7b
Ki AChE 35.0 +/- 9.2 BChE 1.6 +/- 0.1 microM
General
Type : Piperazine, Carboxamide
Chemical_Nomenclature : 1,4-Bis(2-chlorobenzyl)-N-hydroxypiperazine-2-carboxamide
Canonical SMILES : N1(CCN(C(C1)C(O)=O)CC2=C(C=CC=C2)Cl)CC3=CC=CC=C3C
InChI : InChI=1S\/C19H20Cl2N2O2\/c20-16-7-3-1-5-14(16)11-22-9-10-23(18(13-22)19(24)25)12-15-6-2-4-8-17(15)21\/h1-8,18H,9-13H2,(H,24,25)
InChIKey : ASVFYXHMLQISFV-UHFFFAOYSA-N
Other name(s) : Compound 7b
Target
Families : Bischlorobenzyl-hydroxypiperazine-carboxamide-Cpd7b ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies - Soliman_2023_Bioorg.Chem_142_106916 |
| Author(s) : Soliman AM , Abd El-Wahab HAA , Akincioglu H , Gulcin I , Omar FA |
| Ref : Bioorg Chem , 142 :106916 , 2023 |
| Abstract : |
| PubMedSearch : Soliman_2023_Bioorg.Chem_142_106916 |
| PubMedID: 37913584 |