Carboxamide

General

compound with the general formula R1C(=O)NR2R3, where R1, R2, and R3 represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the main chain of a protein. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme familyes Type Structure
ChEs-MAOs-IN-1 Monoamine-oxidase-inhibitor Multitarget Benzodioxo Carboxamide
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
Aryl-carboxamide-benzoxazole-cpd36 BCHE ACHE Carboxamide Benzoxazol Morpholine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen
SEH-48-RK4 Epoxide_hydrolase Carboxamide Sulfur Compound Sulfonamide
SEH-45-RK3 Epoxide_hydrolase Carboxamide Sulfur Compound Sulfonamide
Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b BCHE ACHE Multitarget Indole Carboxamide Sulfur Compound Sulfonamide
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidin Derivative of Donepezil Sulfur Compound
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
Itopride Not A\/B H target Drug Carboxamide Dopamine antagonist Benzamide
BR102910 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide Sulfur Compound
UAMC-1110 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide
IL8 Thioesterase Carboxamide Oxadiazol Azetidin
IKG Thioesterase Carboxamide Cyanide Oxadiazol Azetidin
IJJ Thioesterase Carboxamide Oxadiazol Azetidin
M-18C Monoglyceridelipase_lysophospholip Carboxamide Piperidine Indole
Glimepiride Epoxide_hydrolase Sulfonamide Sulfur Compound Carboxamide Urea derivative
IOCB22-AP446 DPP4N_Peptidase_S9 Pyrrolidine Quinoline Carboxamide
FNDP Epoxide_hydrolase PET probe Carboxamide
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
Compound-60 abh_upf0017 Carboxamide
CHEMBL3104293 BCHE Organophosphate Carboxamide
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
8UW-7Q1P BCHE Carboxamide Diphenylacetamide
9CI-7Q1O BCHE Carboxamide Diphenylacetamide
8IV-7Q1N BCHE Carboxamide Diphenylacetamide
8IS-7Q1M BCHE Carboxamide Diphenylacetamide
Dihydroquinazoline-carboxamide-34 Epoxide_hydrolase Carboxamide Multitarget 5-Lipoxygenase inhibitor Sulfur Compound Quinazoline
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
Benzimidazole-Diethylcarbamoyl-isopentyl-dimethylcarbamate-15d BCHE Cannabinoid-Receptor-ligand Benzimidazole Carbamate Carboxamide
Benzimidazole-Ethoxybenzyl-isopentyl-azetidine-carboxylate-21d BCHE Cannabinoid-Receptor-ligand Benzimidazole Carbamate Carboxamide Azetidin
Benzimidazole-phenyl-azetidine-carboxylate-11d BCHE Cannabinoid-Receptor-ligand Benzimidazole Carbamate Carboxamide Azetidin
S17-1001 BCHE Acetanilide Carboxamide 2-nitrophenyl
Aromatic-tertiary-amine-17c BCHE Naphthalen Carboxamide
Cpd8f-quinoline-carboxamide Hormone-sensitive_lipase_like Quinoline Carboxamide
Z3J-Cmpd6-7M7V Thioesterase Carboxamide Benzofuran
Cpd20-Benzimidazol-Oxadiazol BCHE Benzimidazole Oxadiazol Cyanide Carboxamide
S16-1029 BCHE Benzimidazole Oxadiazol Morpholine Carboxamide
Fragment-810 Pectinacetylesterase-Notum Pyridine Carboxamide
Fragment-791 Pectinacetylesterase-Notum Fragment inhibitor of Notum Carboxamide
Fragment-916 Pectinacetylesterase-Notum Fragment inhibitor of Notum Carboxamide
Fragment-147 Pectinacetylesterase-Notum Fragment inhibitor of Notum Carboxamide Pyridine Not A\/B H target
N-methyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamide Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfur Compound Carboxamide Carbamate
Benzothiazole-analogue-13f Epoxide_hydrolase Benzothiazol Piperidine Sulfur Compound Sulfonamide Carboxamide
FAAH_sEH_4.5 Epoxide_hydrolase Benzothiazol Piperidine Sulfur Compound Carboxamide
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Trifluoro
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL3233609-S0K-3WKD Epoxide_hydrolase Carboxamide Sulfur Compound Morpholine
TK90 Epoxide_hydrolase Butyrate Carboxamide Trifluoro Multitarget PPARgamma ligand
6KZ-4CIA Carboxypeptidase_S10 Carboxamide Morpholine Oxadiazol
4-Oxo-beta-Lactam-B114 DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
4-Oxo-beta-Lactam-B114-closed DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
HT-01 Lipase_3 ABHD6-Lip Fluorescent Probe BODIPY-derivative Carboxamide Triazol Trifluoro Boron compound
6o-5-HT3 BCHE ACHE Multitarget 5-HT-receptor-ligand Derivative of Tacrine Carboxamide Alkyl linked bis-ligand
JF635 Haloalkane_dehalogenase-HLD2 Fluorescent Probe HaloTag-ligand Azetidin Carboxamide Benzofuran Benzosilin
MC1420 ACHE Derivative of Donepezil Carboxamide Chromen
6J1T-B7U Canar_LipB Carboxamide
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Chromen
Regorafenib Epoxide_hydrolase Urea derivative Not A\/B H target Trifluoro Carboxamide multi-kinase inhibitor
Sorafenib Epoxide_hydrolase Urea derivative Not A\/B H target Trifluoro Carboxamide multi-kinase inhibitor
MHETA Tannase Polyesterase-lipase-cutinase Carb_B_Bacteria Benzoate Terephthalate Carboxamide
FG1912 GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6N5G-2 Epoxide_hydrolase Urea derivative Carboxamide
6N5F-3 Epoxide_hydrolase Carboxamide
ZINC12863377 Monoglyceridelipase_lysophospholip Pyrrolidine Indole Carboxamide
6F7Q-cpd11 BCHE Multitarget Antioxidant Piperidine Quinoline Metal ion chelator Inden Carboxamide
BIA-10-2474 Carb_B_Chordata ABHD6-Lip Pyridine Imidazole FAAH inhibitor Multitarget Carboxamide
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide tert-Butyl tert-Butyloxycarbonyl
5LKR-6yc BCHE Piperidine Carboxamide Naphthalen
TAM16 Thioesterase Piperidine Carboxamide Benzofuran
D3C DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Carboxamide
Anagliptin DPP4N_Peptidase_S9 Drug Cyanide Pyrrolidine Gliptin Pyrimidine Carboxamide Pyrazole
Carboxamide-triflurophenyl-D5C DPP4N_Peptidase_S9 Trifluoro Carboxamide
Tiratricol-derivative-8c CFTR-inhibitory-factor_Cif Carboxamide Thyroid hormone analogue Urea derivative
CHEMBL469792 Epoxide_hydrolase Piperidine Sulfur Compound Carboxamide Sulfonyl
CHEMBL2392714 Epoxide_hydrolase Trifluoro Piperidine Carboxamide Triazine
CHEMBL1234565 Epoxide_hydrolase Pyridine Nicotinamide Carboxamide Pyrazole
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
Z-Pro-Prolinal-IC2 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide
Z-Pro-Prolinal-IC4 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide Urea derivative
Z-Pro-Prolinal-derived S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Piperidine Peptide Pyrrolidine Carboxamide Carbamate
24D Epoxide_hydrolase Piperidine Pyrimidine Carboxamide
33N Epoxide_hydrolase Pyridine Nicotinamide Carboxamide
DB07181 DPP4N_Peptidase_S9 Biphenyl Carboxamide
5ALG-R4N Epoxide_hydrolase Carboxamide Sulfur Compound
CHEMBL4465514 Epoxide_hydrolase Piperidine Carboxamide Sulfur Compound
5ALH-4UA Epoxide_hydrolase Sulfonamide Carboxamide Sulfur Compound Piperidine Sulfonyl
5ALU-HD2 Epoxide_hydrolase Adamantyl Urea derivative Carboxamide Pyrimidine Not A\/B H target
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
5ALP-QYD Epoxide_hydrolase Carboxamide Sulfur Compound Thiomorpholine pNP Morpholine
AIL DPP4N_Peptidase_S9 Pyrrolidine Sulfur Compound Thiazolidine Carboxamide
Tetrahydroisoquinoline-derivative DPP4N_Peptidase_S9 Isoquinoline Carboxamide
Tacrine-Trolox-7u ACHE Multitarget Antioxidant Derivative of Tacrine Carboxamide Alkyl linked bis-ligand Chromen
CB1R-ACHE-20 ACHE Multitarget Cannabinoid-Receptor-ligand Derivative of Tacrine Imidazole Carboxamide Alkyl linked bis-ligand
CB2R-BCHE-x BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
CB2R-BCHE-20a BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
Valpromide Epoxide_hydrolase Drug Carboxamide
Tacrine-nicotinamide ACHE Derivative of Tacrine Derivative of Nicotine Alkyl linked bis-ligand Nicotinamide Carboxamide
Z-Gly-Gly-Phe-chloromethyl-ketone ACPH_Peptidase_S9 Benzyloxycarbonyl Carbamate Peptide Ketone Carboxamide
Didemnin-B Palmitoyl-protein_thioesterase Natural Peptide Pyrrolidine Carboxamide
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
MGL-Inhibitor-26 Monoglyceridelipase_lysophospholip Piperidine Carboxamide Pyrazole
GSK2256294A Epoxide_hydrolase Urea derivative Cyanide Carboxamide Triazine
CHEMBL3086040 Prolylcarboxypeptidase Pyridine Carboxamide Morpholine
CHEMBL1215376 DPP4N_Peptidase_S9 Pyrimidine Carboxamide
CHEMBL3145341 Carboxypeptidase_S10 Carboxamide Pyrazole Propionate
CHEMBL2171392 Carboxypeptidase_S10 Carboxamide Pyrazole
AM6701 ABHD6-Lip Monoglyceridelipase_lysophospholip Biphenyl Urea derivative Cannabinoid-Receptor-ligand FAAH inhibitor Multitarget Carboxamide Tetrazol
40V BCHE Piperidine Quinoline Multitarget Carboxamide Metal ion chelator Inden
3F9 BCHE Piperidine Inden Carboxamide Naphthalen
Acotiamide ACHE Drug Sulfur Compound Carboxamide
Dibucaine BCHE Local anesthetic Quinoline Drug Not A\/B H target Carboxamide
Diethylcarbamazine ACHE Piperazine Anthelmintic Not A\/B H target Carboxamide
BChE-IN-21 BCHE Pyridine Quinoline Carboxamide
Triazamate ACHE Carboxamide Insecticide Triazol tert-Butyl Sulfur Compound
LY2183240 Monoglyceridelipase_lysophospholip Arylacetamide_deacetylase ABHD6-Lip Cannabinoid-Receptor-ligand Biphenyl Urea derivative FAAH inhibitor Multitarget Carboxamide Tetrazol
Amiloride ACHE BCHE Carboxamide Drug Pyridine Not A\/B H target