Bromo-hydroxy-methylbenzo-imidazothiazol-oxoethyl-isatin-cpd6c
MAO-B (IC(50) = 0.90 +/- 0.005 microM), AChE (IC(50) = 0.176 +/- 0.02 microM), and BuChE (IC(50) = 0.667 +/6 0.06 microM)
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Thiazole, Sulfur Compound, Imidazol, Isatin, Indole
Chemical_Nomenclature : 5-Bromo-3-hydroxy-3-(2-(3-methylbenzo[4,5]imidazo[2,1-b]thiazol-2-yl)-2-oxoethyl)indolin-2-one
Canonical SMILES : [N]13C(=NC2=C1C=CC=C2)SC(=C3C)C(=O)CC5(C4=CC(=CC=C4NC5=O)Br)O
InChI : InChI=1S\/C20H14BrN3O3S\/c1-10-17(28-19-23-14-4-2-3-5-15(14)24(10)19)16(25)9-20(27)12-8-11(21)6-7-13(12)22-18(20)26\/h2-8,27H,9H2,1H3,(H,22,26)
InChIKey : KEUCYLLEOJTJJI-UHFFFAOYSA-N
Other name(s) : Compound 6c
Target
Families : Bromo-hydroxy-methylbenzo-imidazothiazol-oxoethyl-isatin-cpd6c ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of tricyclic benzo[4,5]imidazo[2,1-b]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors - Eldehna_2026_RSC.Adv__ |
| Author(s) : Eldehna WM , El-Damasy AK , Lim J , Hefny SM , Al-Warhi T , Elgohary AS , El-Hamaky AA , Paik MJ , Elnagar MR , Elimam DM , Omar YM , Kim H , Tawfik HO , Hewala MM , Elsayed ZM , Keum G |
| Ref : RSC Adv , : , 2026 |
| Abstract : |
| PubMedSearch : Eldehna_2026_RSC.Adv__ |
| PubMedID: 42610081 || 42788140 |