BysspectinA-cpd20wderivative
hCES2 IC50 1.6+/-0.34 nM
General
Type : Natural_modified, Benzofuran
Chemical_Nomenclature : 1-(2-(2-hydroxy-5-methoxyphenyl)-5-methylbenzofuran-4-yl)heptan-1-one
Canonical SMILES : C1(=[C][C]=C2C(=C1C(=O)CCCCC[C])[C]=C(O2)C3=[C]C(=[C][C]=C3[O])O[C])[C]
InChI : InChI=1S\/C23H26O4\/c1-4-5-6-7-8-20(25)23-15(2)9-12-21-18(23)14-22(27-21)17-13-16(26-3)10-11-19(17)24\/h9-14,24H,4-8H2,1-3H3
InChIKey : JLIJJLLYTGASQX-UHFFFAOYSA-N
Other name(s) :
Target
Families : BysspectinA-cpd20wderivative ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES1
References (2)
| Title : New bysspectin A derivatives as potent inhibitors of human carboxylesterase 2A - Li_2023_Eur.J.Med.Chem_259_115708 |
| Author(s) : Li W , Zhang Y , Wu Y , Zhu G , Liu X , Song Y , Ma B , Lin S , Ge G , Jiao X , Xie P |
| Ref : Eur Journal of Medicinal Chemistry , 259 :115708 , 2023 |
| PubMedID: 37544184 |
| Title : Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities - Wu_2018_Eur.J.Med.Chem_145_717 |
| Author(s) : Wu YZ , Zhang HW , Sun ZH , Dai JG , Hu YC , Li R , Lin PC , Xia GY , Wang LY , Qiu BL , Zhang JF , Ge GB , Lin S |
| Ref : Eur Journal of Medicinal Chemistry , 145 :717 , 2018 |
| PubMedID: 29353723 |