CHEMBL3601880
IC50 microM AChE 0.088; BChE 0.137
General
Type : Sulfur Compound, Pyrimidine, Uracil derivative
Chemical_Nomenclature : 5-bromo-1-(4-methylphenyl)sulfonylpyrimidine-2,4-dione
Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)N2C=C(C(=O)NC2=O)Br
InChI : InChI=1S\/C11H9BrN2O4S\/c1-7-2-4-8(5-3-7)19(17,18)14-6-9(12)10(15)13-11(14)16\/h2-6H,1H3,(H,13,15,16)
InChIKey : NRJNVUQEXKTTJI-UHFFFAOYSA-N
Other name(s) : SCHEMBL8559503 || BDBM50106395 || 5-Bromo-1-(toluene-4-sulfonyl)-1H-pyrimidine-2,4-dione || Compound 4
MW : 345.17
Formula : C11H9BrN2O4S
CAS_number :
PubChem : 17770844
UniChem : NRJNVUQEXKTTJI-UHFFFAOYSA-N
Target
Families : CHEMBL3601880 ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies - Cavdar_2019_J.Enzyme.Inhib.Med.Chem_34_429 |
| Author(s) : Cavdar H , Senturk M , Guney M , Durdagi S , Kayik G , Supuran CT , Ekinci D |
| Ref : J Enzyme Inhib Med Chem , 34 :429 , 2019 |
| Abstract : |
| PubMedSearch : Cavdar_2019_J.Enzyme.Inhib.Med.Chem_34_429 |
| PubMedID: 30734597 |