CHEMBL4213301
IC50 eleel ACHE 5.17 nM; horse BCHE 3.68 microM
General
Type : Derivative of Tacrine, Acridine, Carboxamide
Chemical_Nomenclature : 9-amino-N-(3-phenylpropyl)-1,2,3,4-tetrahydroacridine-2-carboxamide
Canonical SMILES : C1CC2=NC3=CC=CC=C3C(=C2CC1C(=O)NCCCC4=CC=CC=C4)N
InChI : InChI=1S\/C23H25N3O\/c24-22-18-10-4-5-11-20(18)26-21-13-12-17(15-19(21)22)23(27)25-14-6-9-16-7-2-1-3-8-16\/h1-5,7-8,10-11,17H,6,9,12-15H2,(H2,24,26)(H,25,27)
InChIKey : OYHDIURQIIDFSG-UHFFFAOYSA-N
Other name(s) : BDBM50457037
MW : 359.5
Formula : C23H25N3O
CAS_number :
PubChem : 145966036
UniChem : OYHDIURQIIDFSG-UHFFFAOYSA-N
Target
Families : CHEMBL4213301 ligand of proteins in family
ACHE
References (1)
| Title : Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation - Reddy_2017_Eur.J.Med.Chem_139_367 |
| Author(s) : Reddy EK , Remya C , Mantosh K , Sajith AM , Omkumar RV , Sadasivan C , Anwar S |
| Ref : Eur Journal of Medicinal Chemistry , 139 :367 , 2017 |
| Abstract : |
| PubMedSearch : Reddy_2017_Eur.J.Med.Chem_139_367 |
| PubMedID: 28810188 |