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Derivative of Tacrine

General

Tacrine (tetra trahydroaminacrine) was the first inhibitor of AChE used in Alzheimer's disease but has many side effects and is dicontinued. Tacrine was used as a building block to find less toxic inhibitors or multi target drugs
Inhibitor Main targeted enzyme families Type Structure
Methoxytacripyrine ACHE Calcium Channel Antagonist Derivative of Tacrine Multitarget anti-Abeta-aggregation
SCR-1693 ACHE Calcium Channel Antagonist Derivative of Tacrine Multitarget anti-Abeta-aggregation
TA8Amino ACHE Derivative of Tacrine Derivative of Donepezil Quinoline Piperidine Inden
TAHB3 ACHE Derivative of Tacrine Derivative of Donepezil Piperidine Inden Quinoline
CHEMBL3322160 Acridine Derivative of Tacrine Alkyl linked bis-ligand Multitarget Coumarin Chromen
CHEMBL3393736 Acridine Derivative of Tacrine Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget Hydroxycinnamic-ester Antioxidant
CHEMBL179455 ACHE Acridine Phenanthridinium Derivative of Tacrine Derivative of Propidium Alkyl linked bis-ligand anti-Abeta-aggregation
Methoxybenzoxazol-tacrine-cpd44 Benzoxazol Derivative of Tacrine Acridine Multitarget GSK-3 kinase inhibitor anti-Abeta-aggregation
TAC-BIM-11d ACHE Derivative of Tacrine Acridine Benzimidazole Carboxamide Multitarget anti-Abeta-aggregation
CHDA ACHE Derivative of Tacrine Acridine Azepane anti-Abeta-aggregation
Tacrine-CA-Activator-Cpd30 ACHE BCHE Carbonic anhydrase activator Carbamate Multitarget Derivative of Tacrine Alkyl linked bis-ligand
CHEMBL4278686 ACHE GSK-3 kinase inhibitor Derivative of Tacrine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur Compound
AChE-HDAC-IN-1 ACHE BCHE Multitarget HDAC inhibitor Derivative of Tacrine anti-Abeta-aggregation Antioxidant
HDAC6-IN-5 ACHE Multitarget HDAC inhibitor Derivative of Tacrine anti-Abeta-aggregation
TAC-PhBTA-Cpd16 ACHE Derivative of Tacrine Sulfur Compound Multitarget Benzothiazol
Tacrine-dehydrozingerone ACHE Derivative of Tacrine Multitarget Sulfur Compound
PyrTac-5f ACHE Derivative of Tacrine Multitarget Protein Phosphatase activator Pyridine
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine Antioxidant
Tacrine-selegiline-8g BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand Alkyne
Tacrine-selegiline-7d BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand Alkyne
Di-tert-butyl-phenol-octylamino-acridine-17d ACHE Multitarget Acridine Derivative of Tacrine Antioxidant tert-Butyl Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d BCHE Multitarget Derivative of Tacrine Quinoline Antioxidant tert-Butyl Alkyl linked bis-ligand
7-Methyloxyde-PhO-cpd-II52 ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
7-Methyloxyde-PhO-cpd-I52 ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
7-PhO-THA ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
Amiridine-Admantyl-5d BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Adamantyl NMDA-Ligand Multitarget Naphthalen
Amiridine-thiouracil-13c BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Pyrimidine Sulfur Compound anti-Abeta-aggregation
1d-phosphoryl-dihydroacridine BCHE ACHE Acridine Derivative of Tacrine Antioxidant anti-Abeta-aggregation
10c-Salicylimine-Tacrine BCHE Acridine Derivative of Tacrine Salicylic Alkyl linked bis-ligand
tacrine-isatin-Cpd7k ACHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole Isatin
tacrine-isatin-Cpd7d BCHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole Isatin
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
Propargyl-Tacrine-15 BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Derivative of Tacrine Alkyne
TFAH-tacrine-ferulic-acid-hybrid-10n BCHE Multitarget Acrylate Antioxidant Derivative of Tacrine Hydroxycinnamic-ester Alkyl linked bis-ligand
Bucricaine ACHE Local anesthetic Derivative of Tacrine
Tacrine-dihydropyrimidine-4e ACHE Multitarget Derivative of Tacrine Calcium Channel Antagonist Sulfur Compound Quinoline Pyrimidine
Phenothiazine-Tacrine-1dC ACHE Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
Tacrine-pentylmethylene-tolylsulfonamide ACHE BCHE Alkyl linked bis-ligand Derivative of Tacrine Sulfur Compound Sulfonamide Benzenesulfonamide
K-1234 ACHE Derivative of Huperzine Derivative of Tacrine
2-tolylazo-1,3-aminoenketone-tacrine-7a ACHE Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant
Salicylamide-8-Tacrine ACHE BCHE Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant Salicylic
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
Tacrine-dipicolylamine-13a ACHE Derivative of Tacrine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
DTE-bis8-Tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine Photoswitch Sulfur Compound
AzoTHA ACHE Derivative of Tacrine Acridine Photoswitch
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
PE154 ACHE BCHE Derivative of Tacrine Multitarget Hydrazide Coumarin Chromen
ACHE-GSK-3-27g ACHE GSK-3 kinase inhibitor Derivative of Tacrine Multitarget
Tacrine-methylanacardate-cpd5 BCHE Multitarget Derivative of Tacrine Salicylic Alkyl linked bis-ligand Benzoate
6o-5-HT3 BCHE ACHE Multitarget 5-HT-receptor-ligand Derivative of Tacrine Carboxamide Alkyl linked bis-ligand
6H12-(R)2 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Sulfur Compound Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6H14-(S)6 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
Chlorotacrine-tryptophan-hybrid ACHE BCHE Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
Lipocrine ACHE Multitarget Derivative of Tacrine Antioxidant Sulfur Compound Alkyl linked bis-ligand
E0Z ACHE Derivative of Tacrine Triazol
E1K ACHE Derivative of Tacrine
E1N ACHE Derivative of Tacrine Derivative of Huperzine
Bromophenyl-tacrine6i BCHE ACHE Derivative of Tacrine
NP61 BCHE ACHE Indole Derivative of Tacrine Alkyl linked bis-ligand
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Carbazol beta-carboline Derivative of Tacrine NMDA-Ligand
benzohomoadamantane-chlorotacrine-18a ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine
benzohomoadamantane-chlorotacrine-18b BCHE ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Alkyl linked bis-ligand
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine
Tacrine-Resveratrol-12 ACHE Multitarget Antioxidant Derivative of Tacrine
Tacrine-Trolox-7u ACHE Multitarget Antioxidant Derivative of Tacrine Carboxamide Alkyl linked bis-ligand Chromen
CB1R-ACHE-20 ACHE Multitarget Cannabinoid-Receptor-ligand Derivative of Tacrine Imidazole Carboxamide Alkyl linked bis-ligand
Tacrine-Donepezil-hybrid3 ACHE Derivative of Tacrine Derivative of Donepezil
6-chlorotacrine ACHE Derivative of Tacrine
Tacrine-nicotinamide ACHE Derivative of Tacrine Derivative of Nicotine Alkyl linked bis-ligand Nicotinamide Carboxamide
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand
Compound4Tacrine ACHE Derivative of Tacrine
TADE ACHE BCHE Derivative of Tacrine
Tacrine(8)-4-aminoquinoline ACHE Derivative of Tacrine Quinoline Alkyl linked bis-ligand
Aroylacrylic-acid-amide-Tacrine-10 ACHE BCHE Derivative of Tacrine Alkyl linked bis-ligand
NF595 ACHE Derivative of Tacrine Alkyl linked bis-ligand Sulfur Compound
CI-1002 ACHE Derivative of Tacrine Muscarinic antagonist Quinazoline Azepane
Tz2 ACHE Acridine Derivative of Tacrine Azido
Tz2Pa6-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Derivative of Propidium Alkyl linked bis-ligand Triazol
Tz2Pa5-syn1 ACHE Acridine Phenanthridinium Derivative of Propidium Derivative of Tacrine Alkyl linked bis-ligand Triazol
TZ2PIQA5 ACHE Acridine Quinoline Derivative of Propidium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa6-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Derivative of Propidium Alkyl linked bis-ligand Triazol
Tz2Pa5-anti1 ACHE Acridine Phenanthridinium Derivative of Propidium Derivative of Tacrine Alkyl linked bis-ligand Triazol
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
2-Methoxyhuprine ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
7-Methoxytacrine ACHE Derivative of Tacrine Acridine
7-Nitrotacrine ACHE Derivative of Tacrine Acridine
N-ammoniooctyl-tacrine ACHE Derivative of Tacrine Acridine
N-octyl-tacrine ACHE Derivative of Tacrine Acridine
Tacrine-Benzofuran ACHE BCHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone ACHE Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen
Bis5-tacrine ACHE Derivative of Tacrine Acridine Alkyl linked bis-ligand
Terphenyl-Bistacrine ACHE BCHE Derivative of Tacrine Acridine
Bis7-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
Bis3-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
CHEMBL4456083 BCHE Derivative of Tacrine Alkyl linked bis-ligand Acridine Benzimidazole Carboxamide
HuprineW ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
HuprineX ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
EMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent V-series Surrogate OP Derivative of Tacrine
CMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Tacrine
PMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Soman Derivative of Tacrine
IMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Tacrine Derivative of Sarin
NIK-247 ACHE BCHE Quinoline Derivative of Tacrine Derivative of Amiridine
CHEMBL3343927 beta-carboline Acridine Derivative of Tacrine Multitarget Alkyl linked bis-ligand
SM-10888 ACHE Acridine Derivative of Tacrine
Tacrine ACHE Derivative of Tacrine Acridine
(R)-Tacrine(10)-Hupyridone ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Alkyl linked bis-ligand
Velnacrine ACHE Acridine Derivative of Tacrine
ZA ACHE Acridine Derivative of Tacrine
ZAI ACHE Acridine Derivative of Tacrine
[11C]N-methyl-tacrine ACHE Acridine Derivative of Tacrine PET probe
9-Amino-6-chloro-2-methoxyacridine Carboxylesterase Carb_B_Chordata Acridine Derivative of Tacrine
Tacrine-pyridinealdoxime-1 ACHE Derivative of Tacrine Acridine