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Derivative of Tacrine

General

Tacrine (tetra trahydroaminacrine) was the first inhibitor of AChE used in Alzheimer's disease but has many side effects and is dicontinued. Tacrine was used as a building block to find less toxic inhibitors or multi target drugs
Inhibitor Main targeted enzyme families Type Structure
AChE-HDAC-IN-1 Multitarget HDAC inhibitor Derivative of Tacrine anti-Abeta-aggregation
HDAC6-IN-5 Multitarget HDAC inhibitor Derivative of Tacrine anti-Abeta-aggregation
TAC-PhBTA-Cpd16 ACHE Derivative of Tacrine Sulfur Compound Multitarget Benzothiazol
Tacrine-dehydrozingerone ACHE Derivative of Tacrine Multitarget
PyrTac-5f ACHE Derivative of Tacrine Multitarget Protein Phosphatase activator Pyridine
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine
Tacrine-selegiline-8g BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Tacrine-selegiline-7d BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand prop-2-yn-1-yl
Di-tert-butyl-phenol-octylamino-acridine-17d ACHE Multitarget Acridine Derivative of Tacrine Antioxidant tert-Butyl Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d BCHE Multitarget Derivative of Tacrine Quinoline Antioxidant tert-Butyl Alkyl linked bis-ligand
7-Methyloxyde-PhO-cpd-I52 ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
7-PhO-THA ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
Amiridine-Admantyl-5d BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Adamantyl NMDA-Ligand Multitarget
Amiridine-thiouracil-13c BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Pyrimidine Sulfur Compound anti-Abeta-aggregation
1d-phosphoryl-dihydroacridine BCHE ACHE Acridine Derivative of Tacrine Antioxidant anti-Abeta-aggregation
10c-Salicylimine-Tacrine BCHE Acridine Derivative of Tacrine Salicylic Alkyl linked bis-ligand
tacrine-isatin-Cpd7k ACHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
tacrine-isatin-Cpd7d BCHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
Propargyl-Tacrine-15 BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Derivative of Tacrine Alkyne
TFAH-tacrine-ferulic-acid-hybrid-10n BCHE Multitarget Acrylate Antioxidant Derivative of Tacrine Hydroxycinnamic-ester Alkyl linked bis-ligand
Bucricaine ACHE Local anesthetic Derivative of Tacrine
Tacrine-dihydropyrimidine-4e ACHE Multitarget Derivative of Tacrine Calcium Channel Antagonist Sulfur Compound Quinoline Pyrimidine
Phenothiazine-Tacrine-1dC ACHE Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
Tacrine-pentylmethylene-tolylsulfonamide ACHE BCHE Alkyl linked bis-ligand Derivative of Tacrine Sulfur Compound Sulfonamide Benzenesulfonamide
K-1234 ACHE Derivative of Huperzine Derivative of Tacrine
2-tolylazo-1,3-aminoenketone-tacrine-7a ACHE Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant
Salicylamide-8-Tacrine ACHE BCHE Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant Salicylic
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
Tacrine-dipicolylamine-13a ACHE Derivative of Tacrine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
DTE-bis8-Tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine Photoswitch Sulfur Compound
AzoTHA ACHE Derivative of Tacrine Acridine Photoswitch
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
PE154 ACHE BCHE Derivative of Tacrine Multitarget Hydrazide Coumarin Chromen
ACHE-GSK-3-27g ACHE GSK-3 kinase inhibitor Derivative of Tacrine Multitarget
Tacrine-methylanacardate-cpd5 BCHE Multitarget Derivative of Tacrine Salicylic Alkyl linked bis-ligand Benzoate
6o-5-HT3 BCHE ACHE Multitarget 5-HT-receptor-ligand Derivative of Tacrine Carboxamide Alkyl linked bis-ligand
6H12-(R)2 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6H14-(S)6 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
Chlorotacrine-tryptophan-hybrid ACHE BCHE Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
Lipocrine ACHE Multitarget Derivative of Tacrine Antioxidant Sulfur Compound Alkyl linked bis-ligand
E0Z ACHE Derivative of Tacrine Triazol
E1K ACHE Derivative of Tacrine
E1N ACHE Derivative of Tacrine Derivative of Huperzine
Bromophenyl-tacrine6i BCHE ACHE Derivative of Tacrine
NP61 BCHE ACHE Indole Derivative of Tacrine Alkyl linked bis-ligand
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Carbazol Derivative of Tacrine NMDA-Ligand
benzohomoadamantane-chlorotacrine-18a ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine
benzohomoadamantane-chlorotacrine-18b BCHE ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Alkyl linked bis-ligand
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine
Tacrine-Resveratrol-12 ACHE Multitarget Antioxidant Derivative of Tacrine
Tacrine-Trolox-7u ACHE Multitarget Antioxidant Derivative of Tacrine Carboxamide Alkyl linked bis-ligand Chromen
CB1R-ACHE-20 ACHE Multitarget Cannabinoid-Receptor-ligand Derivative of Tacrine Imidazole Carboxamide Alkyl linked bis-ligand
Tacrine-Donepezil-hybrid3 ACHE Derivative of Tacrine Derivative of Donepezil
6-chlorotacrine ACHE Derivative of Tacrine
Tacrine-nicotinamide ACHE Derivative of Tacrine Derivative of Nicotine Alkyl linked bis-ligand Nicotinamide Carboxamide
Tacrine-Melatonin-Feruloyl-5c BCHE Derivative of Tacrine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand
Compound4Tacrine ACHE Derivative of Tacrine
TADE ACHE BCHE Derivative of Tacrine
Tacrine(8)-4-aminoquinoline ACHE Derivative of Tacrine Quinoline Alkyl linked bis-ligand
Aroylacrylic-acid-amide-Tacrine-10 ACHE BCHE Derivative of Tacrine Alkyl linked bis-ligand
NF595 ACHE Derivative of Tacrine Alkyl linked bis-ligand Sulfur Compound
CI-1002 ACHE Derivative of Tacrine Muscarinic antagonist Quinazoline Azepane
Tz2 ACHE Acridine Derivative of Tacrine Azido
Tz2Pa6-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa5-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
TZ2PIQA5 ACHE Acridine Quinoline Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa6-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa5-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
2-Methoxyhuprine ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
7-Methoxytacrine ACHE Derivative of Tacrine Acridine
7-Nitrotacrine ACHE Derivative of Tacrine Acridine
N-ammoniooctyl-tacrine ACHE Derivative of Tacrine Acridine
N-octyl-tacrine ACHE Derivative of Tacrine Acridine
Tacrine-Benzofuran ACHE BCHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone ACHE Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen
Bis5-tacrine ACHE Derivative of Tacrine Acridine Alkyl linked bis-ligand
Bis7-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
Bis3-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
CHEMBL4456083 BCHE Derivative of Tacrine Alkyl linked bis-ligand Acridine Benzimidazole Carboxamide
HuprineW ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
HuprineX ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
EMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent V-series Surrogate OP Derivative of Tacrine
CMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Tacrine
PMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Soman Derivative of Tacrine
IMP-DDAO ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Tacrine Derivative of Sarin
NIK-247 ACHE BCHE Quinoline Derivative of Tacrine Derivative of Amiridine
SM-10888 ACHE Acridine Derivative of Tacrine
Tacrine ACHE Derivative of Tacrine Acridine
(R)-Tacrine(10)-Hupyridone ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Alkyl linked bis-ligand
Velnacrine ACHE Acridine Derivative of Tacrine
ZA ACHE Acridine Derivative of Tacrine
ZAI ACHE Acridine Derivative of Tacrine
[11C]N-methyl-tacrine ACHE Acridine Derivative of Tacrine PET probe
9-Amino-6-chloro-2-methoxyacridine Carboxylesterase Carb_B_Chordata Acridine Derivative of Tacrine
Tacrine-pyridinealdoxime-1 ACHE Derivative of Tacrine Acridine