Acridine

General

Acridine is a tricyclic compound (C13H9N) with a central pyridine cycle fused with two benzene. Several dyes and drugs feature the acridine skeleton Many acridines, such as proflavine, also have antiseptic properties. Acridine and related derivatives bind to DNA and RNA due to their abilities to intercalate. Tacrine (tetra trahydroaminacrine) was the first inhibitor of AChE used in Alzheimer's disease but has many side effects and is dicontinued
Inhibitor Main targeted enzyme familyes Type Structure
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine
Tacrine-selegiline-8g BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Tacrine-selegiline-7d BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-acridine-17d ACHE Multitarget Acridine Derivative of Tacrine Antioxidant tert-Butyl Alkyl linked bis-ligand
1d-phosphoryl-dihydroacridine Acridine Derivative of Tacrine
10c-Salicylimine-Tacrine BCHE Acridine Derivative of Tacrine Salicylic Alkyl linked bis-ligand
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
Phenothiazine-Tacrine-1dC ACHE Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
DTE-bis8-Tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine Photoswitch Sulfur Compound
AzoTHA ACHE Derivative of Tacrine Acridine Photoswitch
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Tz2 ACHE Acridine Derivative of Tacrine Azido
Tz2Pa6-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa5-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
TZ2PIQA5 ACHE Acridine Quinoline Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa6-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa5-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
7-Methoxytacrine ACHE Derivative of Tacrine Acridine
7-Nitrotacrine ACHE Derivative of Tacrine Acridine
N-ammoniooctyl-tacrine ACHE Derivative of Tacrine Acridine
N-octyl-tacrine ACHE Derivative of Tacrine Acridine
9-Aminoacridine ACHE Acridine
Acridine ACHE Acridine Quinoline
Tacrine-Benzofuran ACHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone ACHE Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen
Bis5-tacrine ACHE Derivative of Tacrine Acridine Alkyl linked bis-ligand
Bis7-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
Bis3-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
N-Methyl-acridinium ACHE Acridine
SM-10888 ACHE Acridine Derivative of Tacrine
Suronacrine ACHE Acridine
Tacrine ACHE Derivative of Tacrine Acridine
Velnacrine ACHE Acridine Derivative of Tacrine
ZA ACHE Acridine Derivative of Tacrine
ZAI ACHE Acridine Derivative of Tacrine
[11C]N-methyl-tacrine ACHE Acridine Derivative of Tacrine PET probe
9-Amino-6-chloro-2-methoxyacridine Carboxylesterase Carb_B_Chordata Acridine Derivative of Tacrine
Tacrine-pyridinealdoxime-1 ACHE Derivative of Tacrine Acridine