CHEMBL5173038
IC50 AChE 20.97 nM
General
Type : Piperidine, Indole, Quinazoline
Chemical_Nomenclature : N-[2-(1H-indol-2-yl)-4-oxo-3H-quinazolin-6-yl]-3-piperidin-1-ylpropanamide
Canonical SMILES : C1CCN(CC1)CCC(=O)NC2=CC3=C(C=C2)N=C(NC3=O)C4=CC5=CC=CC=C5N4
InChI : InChI=1S\/C24H25N5O2\/c30-22(10-13-29-11-4-1-5-12-29)25-17-8-9-20-18(15-17)24(31)28-23(27-20)21-14-16-6-2-3-7-19(16)26-21\/h2-3,6-9,14-15,26H,1,4-5,10-13H2,(H,25,30)(H,27,28,31)
InChIKey : JOCZIAQMXYHQML-UHFFFAOYSA-N
Other name(s) : N-(2-(1H-indol-2-yl)-4-oxo-3,4-dihydroquinazolin-6-yl)-3-(piperidin-1-yl)propanamide || Compound 3h
MW : 415.5
Formula : C24H25N5O2
CAS_number :
PubChem : 136238704
UniChem : JOCZIAQMXYHQML-UHFFFAOYSA-N
Target
Families : CHEMBL5173038 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : 2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling - Li_2013_J.Enzyme.Inhib.Med.Chem_28_583 |
| Author(s) : Li Z , Wang B , Hou JQ , Huang SL , Ou TM , Tan JH , An LK , Li D , Gu LQ , Huang ZS |
| Ref : J Enzyme Inhib Med Chem , 28 :583 , 2013 |
| Abstract : |
| PubMedSearch : Li_2013_J.Enzyme.Inhib.Med.Chem_28_583 |
| PubMedID: 22380775 |