Chloro-dimethyl-trimethoxyphenyl-dispiro-indene-pyrrolidine-indoline-dione-Cpd4o
AChE IC50 0.91 +/- 0.02 microM; BChE IC50 9.11 +/- 0.01 microM
General
Type : Inden, Pyrrolidine, Indole
Chemical_Nomenclature : (2S,4S)5-chloro-1,1-dimethyl-4-(3,4,5-trimethoxyphenyl)dispiro[indene-2,3-pyrrolidine-2,3-indoline]-1,2(3H)-dione
Canonical SMILES : C1=C(C=C(C(=C1OC)OC)OC)[C@H]2C6([C@]3(N(C2)C)C(N(C4=CC=C(C=C34)Cl)C)=O)C(C5=CC=CC=C5C6)=O
InChI : InChI=1S\/C30H29ClN2O5\/c1-32-16-22(18-12-24(36-3)26(38-5)25(13-18)37-4)29(15-17-8-6-7-9-20(17)27(29)34)30(32)21-14-19(31)10-11-23(21)33(2)28(30)35\/h6-14,22H,15-16H2,1-5H3\/t22-,29?,30+\/m0\/s1
InChIKey : KSBKTLYBKSAWEL-IZIRGPAFSA-N
Other name(s) : Compound 4o
Target
Families : Chloro-dimethyl-trimethoxyphenyl-dispiro-indene-pyrrolidine-indoline-dione-Cpd4o ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, X-Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene-Pyrrolidine Derivatives as Multifunctional Anti-Alzheimer Agents - Alsfouk_2026_Drug.Dev.Res_87_e70361 |
| Author(s) : Alsfouk AA , El-Shiekh RA , Kariuki BM , Sabry E , Abouelenein MG , Saleh A , Saleh MGA , Srour AM |
| Ref : Drug Dev Res , 87 :e70361 , 2026 |
| Abstract : |
| PubMedSearch : Alsfouk_2026_Drug.Dev.Res_87_e70361 |
| PubMedID: 42573021 |