Chloro-methyl-phenyl-triazol-oxoethylthio-phenylquinazolinone-Cpd5h
MAO-B (IC(50) = 0.65 microM), AChE (IC(50) = 0.084 microM), and BuChE (IC(50) = 0.667 microM)
General
Type : Multitarget, Antioxidant, Monoamine-oxidase-inhibitor, Quinazoline, Triazol, Sulfur Compound
Chemical_Nomenclature : 7-Chloro-2-((2-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-2-oxoethyl)thio)-3-phenylquinazolin-4(3H)-one
Canonical SMILES : C1=CC(=CC2=C1C(N(C(=N2)SCC(C3=C([N](N=N3)C4=CC=CC=C4)C)=O)C5=CC=CC=C5)=O)Cl
InChI : InChI=1S\/C25H18ClN5O2S\/c1-16-23(28-29-31(16)19-10-6-3-7-11-19)22(32)15-34-25-27-21-14-17(26)12-13-20(21)24(33)30(25)18-8-4-2-5-9-18\/h2-14H,15H2,1H3
InChIKey : FQXXQTLMTLNALN-UHFFFAOYSA-N
Other name(s) : Compound 5h
Target
Families : Chloro-methyl-phenyl-triazol-oxoethylthio-phenylquinazolinone-Cpd5h ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of tricyclic benzo[4,5]imidazo[2,1-b]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors - Eldehna_2026_RSC.Adv__ |
| Author(s) : Eldehna WM , El-Damasy AK , Lim J , Hefny SM , Al-Warhi T , Elgohary AS , El-Hamaky AA , Paik MJ , Elnagar MR , Elimam DM , Omar YM , Kim H , Tawfik HO , Hewala MM , Elsayed ZM , Keum G |
| Ref : RSC Adv , : , 2026 |
| Abstract : |
| PubMedSearch : Eldehna_2026_RSC.Adv__ |
| PubMedID: 42610081 || 42788140 |