Cpd227
General
Type : Urea derivative, Trifluoro
Chemical_Nomenclature : 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-cyclohexylurea
Canonical SMILES : C1CCC(CC1)NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F
InChI : InChI=1S\/C14H16ClF3N2O\/c15-12-7-6-10(8-11(12)14(16,17)18)20-13(21)19-9-4-2-1-3-5-9\/h6-9H,1-5H2,(H2,19,20,21)
InChIKey : QNXXWUCWZJDNQL-UHFFFAOYSA-N
Other name(s) : N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-cyclohexylurea || 3-[4-Chloro-3-(trifluoromethyl)phenyl]-1-cyclohexylurea
MW : 320.74
Formula : C14H16ClF3N2O
CAS_number : 392707-84-5
PubChem : 1040540
UniChem : QNXXWUCWZJDNQL-UHFFFAOYSA-N
Target
Families : Cpd227 ligand of proteins in family
Epoxide_hydrolase
Protein :
myctu-ephB
myctu-ephE
References (1)
| Title : Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly - Mostert_2025_Chem.Sci__ |
| Author(s) : Mostert D , Braun J , Zimmerman MD , Engelhart CA , Berndl S , Quoika PK , Kany AM , Proietto J , Penalva-Lopez S , Wallach JB , Hirsch AKH , Zacharias M , Schnappinger D , Dartois V , Sieber SA |
| Ref : Chem Sci , : , 2025 |
| Abstract : |
| PubMedSearch : Mostert_2025_Chem.Sci__ |
| PubMedID: 40313523 |
| Gene_locus related to this paper: myctu-ephd , myctu-ephF |