Cyanobenzoyl-hydrazineylidene-methyl-fluorobenzyl-pyridinium-Cpd8b
AChE IC50 0.026 +/- 0.005 microM; BACE-1 IC50 124.1 +/- 28.18 microM
General
Type : Cyanide, Multitarget, BACE1-inhibitor, Pyridine, Pyridinium, Hydrazide
Chemical_Nomenclature : (E)-4-((2-(3-cyanobenzoyl)hydrazineylidene)methyl)-1-(2-fluorobenzyl)pyridin-1-ium bromide
Canonical SMILES : C1=CC(=CC(=C1)C(NN=CC2=CC=[N+](C=C2)CC3=CC=CC=C3F)=O)C#N.[Br-]
InChI : InChI=1S\/C21H15FN4O.BrH\/c22-20-7-2-1-5-19(20)15-26-10-8-16(9-11-26)14-24-25-21(27)18-6-3-4-17(12-18)13-23\;\/h1-12,14H,15H2\;1H
InChIKey : DPSQMMHQNUCKHB-UHFFFAOYSA-N
Other name(s) : Compound 8b
Target
Families : Cyanobenzoyl-hydrazineylidene-methyl-fluorobenzyl-pyridinium-Cpd8b ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Novel hydrazone-linked pyridin-1-ium salts as multi-targeted agents for Alzheimer's disease: design, synthesis, in vitro and in silico studies - Tran_2026_Bioorg.Med.Chem_142_118778 |
| Author(s) : Tran H , Tien LQ , Hien TTT , Vinh TX , Duc VM , Xuan TTT , Hien NT , Linh TVT , Thang NQ , Minh PTN , Nguyen TK , Nguyen TH , Pham DV , Wang S , Tran PT |
| Ref : Bioorganic & Medicinal Chemistry , 142 :118778 , 2026 |
| Abstract : |
| PubMedSearch : Tran_2026_Bioorg.Med.Chem_142_118778 |
| PubMedID: 42641464 |