D40
hBuChE IC50 value of 0.59 +/- 0.03 microM anti neuroinflammation
General
Type : Carbamate, Multitarget
Chemical_Nomenclature : (E)-4-(2-(3-(benzyloxy)-4-oxo-4H-pyran-2-yl) vinyl)-1,2-phenylene bis(ethyl(methyl)carbamate)
Canonical SMILES : C1=COC(=C(C1=O)OCC2=CC=CC=C2)C=CC3=CC=C(C(=C3)OC(N(CC)C)=O)OC(=O)N(C)CC
InChI : InChI=1S\/C28H30N2O7\/c1-5-29(3)27(32)36-23-14-12-20(18-25(23)37-28(33)30(4)6-2)13-15-24-26(22(31)16-17-34-24)35-19-21-10-8-7-9-11-21\/h7-18H,5-6,19H2,1-4H3
InChIKey : UHDIDHHBRIFGEW-UHFFFAOYSA-N
Other name(s) :
Target
Families : D40 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : A novel carbamate-based hybrid derivative with anti-neuroinflammatory properties as a selective butyrylcholinesterase inhibitor for Alzheimer's disease therapy - Liu_2025_Bioorg.Chem_161_108551 |
| Author(s) : Liu X , Xu J , Yu C , Dai C , Chen J , Zhong J , Yang Y , Lin H , Chen X , Zhang Q , Dai L , Zhang J , Zha D , Ye ZC |
| Ref : Bioorg Chem , 161 :108551 , 2025 |
| Abstract : |
| PubMedSearch : Liu_2025_Bioorg.Chem_161_108551 |
| PubMedID: 40347768 |