DHEA-dimethylpyrazole-carboxylate
AChE IC50 = 0.15 microM; BuChE IC50 = 0.7 microM
General
Chemical_Nomenclature : 5-androsten-17-one-3beta-yl 3,5-dimethyl pyrazole-1-carboxylate
Canonical SMILES : C2[C@@H](CC1=CC[C@@H]3[C@@H]([C@]1(C2)C)CC[C@]4([C@H]3CCC4=O)C)OC([N]5N=C(C=C5C)C)=O
InChI : InChI=1S\/C25H34N2O3\/c1-15-13-16(2)27(26-15)23(29)30-18-9-11-24(3)17(14-18)5-6-19-20-7-8-22(28)25(20,4)12-10-21(19)24\/h5,13,18-21H,6-12,14H2,1-4H3\/t18-,19-,20-,21-,24-,25-\/m0\/s1
InChIKey : IJTOHPSSPSACNY-FYVXYBBASA-N
Other name(s) : Compound D9
Target
Families : DHEA-dimethylpyrazole-carboxylate ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : DHEA-carbamate derivatives as dual cholinesterase inhibitors: Integration of enzymatic and biomolecular interactions in Alzheimer's disease - Nar_2025_Bioorg.Chem_164_108901 |
| Author(s) : Nar K , Erdagi SI , Ozbagci DI |
| Ref : Bioorg Chem , 164 :108901 , 2025 |
| Abstract : |
| PubMedSearch : Nar_2025_Bioorg.Chem_164_108901 |
| PubMedID: 40850285 |