Isolated from Evodia rutaecarpa Bentham (CAS of chloride salt 75853-60-0) moderate AChE inhibition. Long-lasting facilitation of synaptic transmission due to activation of both muscarinic and NMDA receptors
Type : Natural, Pyridine, Indole, beta-carboline, Natural_modified, Derivative of Evodiamine
Chemical_Nomenclature : Indolo(2',3':3,4)pyrido(2,1-b)quinazolinium, 5,7,8,13-tetrahydro-14-methyl-5-oxo-, hydroxide, inner salt
Canonical SMILES : CN1C2=CC=CC=C2C(=O)[N+]3=C1C4=C(CC3)C5=CC=CC=C5N4.[Cl-]
InChI : InChI=1S\/C19H15N3O.ClH\/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22\;\/h2-9H,10-11H2,1H3\;1H
InChIKey : SVOMSEHNGXLQRU-UHFFFAOYSA-N
Other name(s) : DHED, Dehydroevodiamine chloride, Dehydroevodiamine, CCRIS 8946, AC1L4G2F
MW : 337.80
Formula : C19H16N3O.Cl
CAS_number : 67909-49-3 || 75853-60-0
PubChem : 156371
UniChem : SVOMSEHNGXLQRU-UHFFFAOYSA-N
Families : Dehydroevodiamine ligand of proteins in family
ACHE
Title : Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine - Decker_2005_Eur.J.Med.Chem_40_305 |
Author(s) : Decker M |
Ref : Eur Journal of Medicinal Chemistry , 40 :305 , 2005 |
PubMedID: 15725500 |