Dehydroevodiamine
Isolated from Evodia rutaecarpa Bentham (CAS of chloride salt 75853-60-0) moderate AChE inhibition. Long-lasting facilitation of synaptic transmission due to activation of both muscarinic and NMDA receptors
General
Type : Natural, Pyridine, Indole, beta-carboline, Natural_modified, Derivative of Evodiamine
Chemical_Nomenclature : Indolo(2',3':3,4)pyrido(2,1-b)quinazolinium, 5,7,8,13-tetrahydro-14-methyl-5-oxo-, hydroxide, inner salt
Canonical SMILES : CN1C2=CC=CC=C2C(=O)[N+]3=C1C4=C(CC3)C5=CC=CC=C5N4.[Cl-]
InChI : InChI=1S\/C19H15N3O.ClH\/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22\;\/h2-9H,10-11H2,1H3\;1H
InChIKey : SVOMSEHNGXLQRU-UHFFFAOYSA-N
Other name(s) : DHED || Dehydroevodiamine chloride || Dehydroevodiamine || CCRIS 8946 || AC1L4G2F
MW : 337.80
Formula : C19H16N3O.Cl
CAS_number : 67909-49-3, 75853-60-0
PubChem : 156371
UniChem : SVOMSEHNGXLQRU-UHFFFAOYSA-N
Target
Families : Dehydroevodiamine ligand of proteins in family
ACHE
References (3)
| Title : Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine - Decker_2005_Eur.J.Med.Chem_40_305 |
| Author(s) : Decker M |
| Ref : Eur Journal of Medicinal Chemistry , 40 :305 , 2005 |
| Abstract : |
| PubMedSearch : Decker_2005_Eur.J.Med.Chem_40_305 |
| PubMedID: 15725500 |
| Title : Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice - Wang_2001_Eur.J.Pharmacol_413_221 |
| Author(s) : Wang HH , Chou CJ , Liao JF , Chen CF |
| Ref : European Journal of Pharmacology , 413 :221 , 2001 |
| Abstract : |
| PubMedSearch : Wang_2001_Eur.J.Pharmacol_413_221 |
| PubMedID: 11226396 |
| Title : Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa - Park_1996_Planta.Med_62_405 |
| Author(s) : Park CH , Kim SH , Choi W , Lee YJ , Kim JS , Kang SS , Suh YH |
| Ref : Planta Med , 62 :405 , 1996 |
| Abstract : |
| PubMedSearch : Park_1996_Planta.Med_62_405 |
| PubMedID: 8923803 |