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beta-carboline

General

The prototype of a class of indole alkaloid compounds widespread in prokaryotes, plants and animals. Synthetically designed beta-carboline derivatives have recently been shown to have neuroprotective, cognitive enhancing, anti-cancer and antioxidant properties. GSK-3 kinase inhibitors. Belongs to indole alkaloids and consist of a pyridine ring that is fused to an indole skeleton
Inhibitor Main targeted enzyme families Type Structure
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
Evodiamine BCHE Derivative of Evodiamine Natural beta-carboline Not AlphaBeta Hydrolase target Multitarget
Harmine Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
Methylene-blue-carboline-2 ACHE BCHE Cholinesterase Dye Multitarget Indole Phenothiazine beta-carboline Sulfur Compound
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Carbazol beta-carboline Derivative of Tacrine NMDA-Ligand
NMDA-BCHE-C-2h BCHE Multitarget NMDA-Ligand Carbazol beta-carboline Adamantyl
ST052207 BCHE Quinoline Carbazol beta-carboline
Peganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Natural_modified
Harmol Not AlphaBeta Hydrolase target beta-carboline Natural
Desoxypeganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Quinazoline
Dehydroevodiamine ACHE Natural Pyridine Indole beta-carboline Natural_modified Derivative of Evodiamine
Fluoro-piperidin-ethyl-carbazole-15g BCHE Piperidine Carbazol beta-carboline
N-benzylpiperidine-carbazol-9c BCHE Piperidine Carbazol beta-carboline Derivative of Donepezil Multitarget Benzylpiperidine
CHEMBL1088377 beta-carboline Multitarget
CHEMBL3343927 beta-carboline Acridine Derivative of Tacrine Multitarget Alkyl linked bis-ligand
Gamma-carboline-phenothiazine-Cpd7b BCHE beta-carboline Phenothiazine Indole NMDA-Ligand Multitarget
Gamma-carboline-nonyl-bivalent BCHE ACHE beta-carboline Indole NMDA-Ligand Multitarget Alkyl linked bis-ligand