Diallyl-biphenyl-diyl-bis(diethylcarbamate)
Derivative of natrural product HK-1; IC50 0.43 microM
General
Type : Carbamate
Chemical_Nomenclature : 3',5-Diallyl-[1,1'-biphenyl]-2,4'-diyl bis(diethylcarbamate)
Canonical SMILES : C1(=CC(=C(C=C1)OC(N(CC)CC)=O)C2=CC=C(C(=C2)CC=C)OC(N(CC)CC)=O)CC=C
InChI : InChI=1S\/C28H36N2O4\/c1-7-13-21-15-17-26(34-28(32)30(11-5)12-6)24(19-21)22-16-18-25(23(20-22)14-8-2)33-27(31)29(9-3)10-4\/h7-8,15-20H,1-2,9-14H2,3-6H3
InChIKey : VPDMKKDNKWAQPF-UHFFFAOYSA-N
Other name(s) : Compound 3c
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Target
Families : Diallyl-biphenyl-diyl-bis(diethylcarbamate) ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Artificial intelligence-driven development of natural multi-target derivatives with BuChE inhibitory activity for treating Alzheimer's disease - Zhang_2025_Chin.Chem.Lett__110964 |
| Author(s) : Zhang Q , Li Y , Jin Q , Liu Z , Chen H , Huang J , Liu T , Liu X , Tan Z , Huang S , Dong W , Sang Z |
| Ref : Chin Chem Lett , :110964 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_Chin.Chem.Lett__110964 |
| PubMedID: |