Dichloro-cyanobenzo-imidazo-pyrimidin-methoxybenzamide
IC50 for eleel AChE 14.89 +/- 2.00 (nM); IC50 for horse BChE 357.00 +/- 48.61 (nM)
General
Type : Carboxamide, Pyrimidine, Benzamide, Imidazol, Benzimidazole
Chemical_Nomenclature : 3,5-dichloro-N-(3-cyanopyrimido[1,2-a]benzimidazol-2-yl)-2-methoxybenzamide
Canonical SMILES : COC1=C(C=C(C=C1Cl)Cl)C(=O)NC2=NC3=NC4=CC=CC=C4N3C=C2C#N
InChI : InChI=1S\/C19H11Cl2N5O2\/c1-28-16-12(6-11(20)7-13(16)21)18(27)24-17-10(8-22)9-26-15-5-3-2-4-14(15)23-19(26)25-17\/h2-7,9H,1H3,(H,23,24,25,27)
InChIKey : YQMPCZJWUVKKTB-UHFFFAOYSA-N
Other name(s) : AKOS024421658 || 3,5-Dichloro-N-(3-cyanobenzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)-2-methoxybenzamide
MW : 412.2
Formula : C19H11Cl2N5O2
CAS_number : 116477-82-8
PubChem : 3393465
UniChem : YQMPCZJWUVKKTB-UHFFFAOYSA-N
Target
Families : Dichloro-cyanobenzo-imidazo-pyrimidin-methoxybenzamide ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Evaluation of pyrimidine-based compounds as AChE and BChE inhibitors: in vitro inhibition, molecular modeling, and statistical evaluation - Alim_2026_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
| Author(s) : Alim Z , Demir Y |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , : , 2026 |
| Abstract : |
| PubMedSearch : Alim_2026_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
| PubMedID: 42024241 |