Diethylamino-chromen-thiazol-acetamide
AChE IC50 43 nM
General
Type : Thiazole, Sulfur Compound, Coumarin, Chromen
Chemical_Nomenclature : 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide
Canonical SMILES : C1=CC=C2C(=C1)OC(C(=C2)C3=CSC(=N3)NC(CN(CC)CC)=O)=O
InChI : InChI=1S\/C18H19N3O3S\/c1-3-21(4-2)10-16(22)20-18-19-14(11-25-18)13-9-12-7-5-6-8-15(12)24-17(13)23\/h5-9,11H,3-4,10H2,1-2H3,(H,19,20,22)
InChIKey : CEKHYXKLTYVPRQ-UHFFFAOYSA-N
Other name(s) : Compound 6c
Target
Families : Diethylamino-chromen-thiazol-acetamide ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors - Sonmez_2017_J.Enzyme.Inhib.Med.Chem_32_285 |
| Author(s) : Sonmez F , Zengin Kurt B , Gazioglu I , Basile L , Dag A , Cappello V , Ginex T , Kucukislamoglu M , Guccione S |
| Ref : J Enzyme Inhib Med Chem , 32 :285 , 2017 |
| Abstract : |
| PubMedSearch : Sonmez_2017_J.Enzyme.Inhib.Med.Chem_32_285 |
| PubMedID: 28097911 |