Dimethoxyquinazolin-fluorobenzohydrazide-Cpd3
AChE IC50 439 nM. BACE-1 IC50 of 1.989 microM
General
Type : Quinazoline, Multitarget, Hydrazide, BACE1-inhibitor
Chemical_Nomenclature : N'-(6,7-Dimethoxyquinazolin-4-yl)-2-fluorobenzohydrazide
Canonical SMILES : C1(=C(C=C2C(=C1)C(=NC=N2)NNC(C3=C(C=CC=C3)F)=O)OC)OC
InChI : InChI=1S\/C17H15FN4O3\/c1-24-14-7-11-13(8-15(14)25-2)19-9-20-16(11)21-22-17(23)10-5-3-4-6-12(10)18\/h3-9H,1-2H3,(H,22,23)(H,19,20,21)
InChIKey : GGLKFGQNKAGSNT-UHFFFAOYSA-N
Other name(s) : Compound 3
Target
Families : Dimethoxyquinazolin-fluorobenzohydrazide-Cpd3 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of 6,7-Dimethoxyquinazoline-Hydrazide Hybrids as Dual Inhibitors of Acetylcholinesterase and beta-Secretase - Antoniolli_2026_Biochimie__ |
| Author(s) : Antoniolli G , Nemr MTM , Marques SPD , Sebakhy KO , Barbosa EG , Trevisan MTS , Coelho F , Elshewy A |
| Ref : Biochimie , : , 2026 |
| Abstract : |
| PubMedSearch : Antoniolli_2026_Biochimie__ |
| PubMedID: 41720243 |