Dimethylphenyl-hydrazineylidene-methyl-fluoro-indole-CpdK10
IC50 AChE 19.11 nM; IC50 BChE 48.37 nM; Ki AChE 10.10 +/- 1.77 nM; Ki BChE15.26 +/- 3.09 nM
General
Type : Hydrazide, Hydrazinylidene, Indole
Chemical_Nomenclature : 3-((2-(3,5-dimethylphenyl)hydrazineylidene)methyl)-5-fluoro-1H-indole
Canonical SMILES : C1(=C[N]C2=CC=C(C=C12)F)C=NNC3=CC(=CC(=C3)C)C
InChI : InChI=1S\/C17H16FN3\/c1-11-5-12(2)7-15(6-11)21-20-10-13-9-19-17-4-3-14(18)8-16(13)17\/h3-10,19,21H,1-2H3
InChIKey : IKCROBLZXBWGHN-UHFFFAOYSA-N
Other name(s) : Compound K10
Target
Families : Dimethylphenyl-hydrazineylidene-methyl-fluoro-indole-CpdK10 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Synthesis and characterization of novel 5-fluoroindolylmethylene hydrazone derivatives as schiff base compounds: In vitro and in silico evaluation as potential cholinesterase (AChE and BChE) inhibitors, - Koprulu_2026_J.Indian.Chem.Soc_103_102484 |
| Author(s) : Koprulu C , Faydali N , Muhammed MT , Dilek E , Kucukoglu K , Sirinzade H |
| Ref : J Indian Chem Soc , 103 :102484 , 2026 |
| Abstract : |
| PubMedSearch : Koprulu_2026_J.Indian.Chem.Soc_103_102484 |
| PubMedID: |