FZQ-21
stilbene-extended scaffold sEH IC50 4.0 nM
General
Type : Urea derivative, Pyridine
Chemical_Nomenclature : N-[3-[(E)-2-[4-(oxan-4-ylmethylcarbamoylamino)phenyl]ethenyl]phenyl]-2-pyridin-2-ylacetamide
Canonical SMILES : C1COCCC1CNC(=O)NC2=CC=C(C=C2)\/C=C\/C3=CC(=CC=C3)NC(=O)CC4=CC=CC=N4
InChI : InChI=1S\/C28H30N4O3\/c33-27(19-25-5-1-2-15-29-25)31-26-6-3-4-22(18-26)8-7-21-9-11-24(12-10-21)32-28(34)30-20-23-13-16-35-17-14-23\/h1-12,15,18,23H,13-14,16-17,19-20H2,(H,31,33)(H2,30,32,34)\/b8-7+
InChIKey : IODWOBIUCMOQJZ-BQYQJAHWSA-N
Other name(s) : Compound 70P || CHEMBL5572264 || EX-A12876 || HY-162120 || CS-0928332 || (E)-2-(pyridin-2-yl)-N-(3-(4-(3-((tetrahydro-2H-pyran-4-yl)methyl)ureido)styryl) phenyl)acetamide
MW : 470.6
Formula : C28H30N4O3
CAS_number : 3054131-13-1
PubChem : 170453200
UniChem : IODWOBIUCMOQJZ-BQYQJAHWSA-N
Target
Families : FZQ-21 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (3)
| Title : Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors - Feng_2024_Eur.J.Med.Chem_266_116113 |
| Author(s) : Feng ZQ , Ding J , Zhu MZ , Xie WS , Liu RC , Liu SS , Liu SM , Yu MJ , Zhu XH , Liang JH |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116113 , 2024 |
| Abstract : |
| PubMedSearch : Feng_2024_Eur.J.Med.Chem_266_116113 |
| PubMedID: 38215588 |
| Title : Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors - Feng_2024_Eur.J.Med.Chem_266_116113 |
| Author(s) : Feng ZQ , Ding J , Zhu MZ , Xie WS , Liu RC , Liu SS , Liu SM , Yu MJ , Zhu XH , Liang JH |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116113 , 2024 |
| Abstract : |
| PubMedSearch : Feng_2024_Eur.J.Med.Chem_266_116113 |
| PubMedID: 38215588 |
| Title : Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors - Feng_2024_Eur.J.Med.Chem_266_116113 |
| Author(s) : Feng ZQ , Ding J , Zhu MZ , Xie WS , Liu RC , Liu SS , Liu SM , Yu MJ , Zhu XH , Liang JH |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116113 , 2024 |
| Abstract : |
| PubMedSearch : Feng_2024_Eur.J.Med.Chem_266_116113 |
| PubMedID: 38215588 |