Fenoverine
Fenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome. Inactive on ACHE; IC50 0.09 +/- 0.01 microM BCHE. fenoverine does not act as a muscarinic or opiate-receptor antagonist, but modulates of the cellular calcium flow
General
Type : Not A\/B H target, Drug, Phenothiazine, Sulfur Compound, Piperazine, Benzodioxo
Chemical_Nomenclature : 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone
Canonical SMILES : C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
InChI : InChI=1S\/C26H25N3O3S\/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22\/h1-10,15H,11-14,16-18H2
InChIKey : UBAJTZKNDCEGKL-UHFFFAOYSA-N
Other name(s) : Spasmopriv, UNII-N274ZQ6PZJ, N274ZQ6PZJ, SCHEMBL25003, CHEMBL1512949, CHEBI:135744, ZINC19899628, DB13042
MW : 459.6
Formula : C26H25N3O3S
CAS_number : 37561-27-6
PubChem : 72098
UniChem : UBAJTZKNDCEGKL-UHFFFAOYSA-N
Target
Families : Fenoverine ligand of proteins in family
BCHE
References (1)
| Title : Identification of Compounds for Butyrylcholinesterase Inhibition - Li_2021_SLAS.Discov__24725552211030897 |
| Author(s) : Li S , Li AJ , Travers J , Xu T , Sakamuru S , Klumpp-Thomas C , Huang R , Xia M |
| Ref : SLAS Discov , :24725552211030897 , 2021 |
| PubMedID: 34269114 |