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Drug

General

Compounds that are used or were used or marketed as medication. A chemical substance used to treat, cure, prevent, or diagnose a disease
Inhibitor Main targeted enzyme families Type Structure
Duloxetine BCHE Drug Multitarget Sodium:neurotransmitter symporter Naphthalen Sulfur Compound Thiophen
Periciazine BCHE Not AlphaBeta Hydrolase target Phenothiazine Multitarget Drug Sulfur Compound Piperidine Cyanide
Retagliptin DPP4N_Peptidase_S9 Drug Gliptin Triazol Trifluoro Pro-Drug Imidazole
Itopride ACHE Not AlphaBeta Hydrolase target Drug Carboxamide Dopamine antagonist Benzamide
Sofosbuvir Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target
Loperamide Carb_B_Chordata Piperidine Drug Not AlphaBeta Hydrolase target Opioid analgesic
Imidocarb Urea derivative Drug
Valsartan Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Drug Tetrazol
Felbinac Pectinacetylesterase-Notum Fragment inhibitor of Notum Drug Not AlphaBeta Hydrolase target
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Riluzole Pectinacetylesterase-Notum Drug Benzothiazol Trifluoro Sulfur Compound Not AlphaBeta Hydrolase target Fragment inhibitor of Notum
Bepridil Pectinacetylesterase-Notum Pyrrolidine Not AlphaBeta Hydrolase target Drug Calcium Channel Antagonist
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
Fenoverine BCHE Not AlphaBeta Hydrolase target Drug Phenothiazine Sulfur Compound Piperazine Benzodioxo
Remdesivir Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Triazine
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Carbamate Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand
CHEMBL1784957 ACHE Drug Pro-Drug Carbamate Derivative of Rivastigmine
Tilorone ACHE Drug Fluoren
Caffeine Pectinacetylesterase-Notum Lipase_3 Purine Alkaloid Natural Drug Not AlphaBeta Hydrolase target
Amodiaquine ACHE Quinoline Not AlphaBeta Hydrolase target Drug
Anagliptin DPP4N_Peptidase_S9 Drug Cyanide Pyrrolidine Gliptin Pyrimidine Carboxamide Pyrazole
Eprotirome CFTR-inhibitory-factor_Cif Thyroid hormone analogue Drug Urea derivative
Tiratricol CFTR-inhibitory-factor_Cif Natural Drug Thyroid hormone analogue
Fulvestrant Epoxide_hydrolase Trifluoro Sulfur Compound Drug Not AlphaBeta Hydrolase target Phenanthrene
Carmegliptin DPP4N_Peptidase_S9 Drug Pyrrolidine Gliptin Quinolizine
Dutogliptin DPP4N_Peptidase_S9 Drug Pyrrolidine Gliptin Boron Compound
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro
Gosogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin
Trelagliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur Compound Pyrazole
Valpromide Epoxide_hydrolase Drug Carboxamide
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Drug
GSK2256294A Epoxide_hydrolase Urea derivative Cyanide Carboxamide Triazine Drug
Ar9281 Epoxide_hydrolase Adamantyl Urea derivative Drug
Methylene-blue ACHE BCHE Dye Drug Phenothiazine anti-tau-aggregation Multitarget Sulfur Compound Antioxidant
Evogliptin DPP4N_Peptidase_S9 Drug Gliptin Trifluoro
Saxagliptin DPP4N_Peptidase_S9 Adamantyl Drug Cyanide Pyrrolidine Gliptin Azabicyclo
Linagliptin DPP4N_Peptidase_S9 Drug Purine Gliptin Quinazoline
Vildagliptin DPP4N_Peptidase_S9 Drug Pyrrolidine Gliptin Adamantyl Cyanide
Alogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
Sitagliptin DPP4N_Peptidase_S9 Drug Piperidine Gliptin Triazol Trifluoro
Demecarium ACHE BCHE Trimethylammonium Bisquaternary Drug
Mylaxen BCHE Neuromuscular Nondepolarizing Agents Drug Fluoren
Ladostigil ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Drug Inden
Acotiamide ACHE Drug Sulfur Compound Carboxamide
Ambenonium BCHE Bisquaternary Drug
Pyridophen-10 ACHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not AlphaBeta Hydrolase target PET probe
Dimethylhydroxycarbaphen BCHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not AlphaBeta Hydrolase target
Aricept~Donepezil~E2020 ACHE Derivative of Donepezil Piperidine Drug Inden
Atracurium BCHE Not AlphaBeta Hydrolase target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate
Atropine ACHE Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Terbutaline-monocarbamate BCHE Derivative of Bambuterol Carbamate Drug tert-Butyl Not AlphaBeta Hydrolase target Pro-Drug
Bambuterol BCHE Derivative of Bambuterol Carbamate Drug tert-Butyl Not AlphaBeta Hydrolase target Pro-Drug
Carbachol ACHE BCHE Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
Chlorpromazine ACHE BCHE Not AlphaBeta Hydrolase target Phenothiazine Multitarget Drug Sulfur Compound
Cocaine BCHE Natural Not AlphaBeta Hydrolase target Drug Alkaloid Benzoate
D-tubocurarine ACHE Natural Alkaloid Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Drug
Decamethonium BCHE Bisquaternary Trimethylammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Dibucaine BCHE Local anesthetic Quinoline Drug Not AlphaBeta Hydrolase target Carboxamide
Echothiophate BCHE Drug Organophosphate Sulfur Compound Organothiophosphate Trimethylammonium
Edrophonium ACHE BCHE Drug Quaternary compound
Rivastigmine ACHE Derivative of Rivastigmine Carbamate Drug
Ethopropazine BCHE ACHE Phenothiazine Drug Sulfur Compound
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist
Tyramine BCHE Adrenergic Uptake Inhibitors Not AlphaBeta Hydrolase target Drug
Imipramine BCHE Adrenergic Uptake Inhibitors Not AlphaBeta Hydrolase target Drug Azepane Benzazepin
SN-38 Carb_B_Bacteria Carb_B_Chordata Drug Derivative of Irinotecan Not AlphaBeta Hydrolase target Pro-Drug
Irinotecan Carboxylesterase Carb_B_Chordata Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan Not AlphaBeta Hydrolase target
Meperidine BCHE Carboxylesterase Carb_B_Chordata Piperidine Drug Not AlphaBeta Hydrolase target Opioid analgesic
Methylprednisolone BCHE Drug Steroid Phenanthrene Not AlphaBeta Hydrolase target
Methylprednisolone-acetate BCHE Steroid Drug Acetate Phenanthrene
Metoclopramide BCHE Benzamide Dopamine antagonist Drug Not AlphaBeta Hydrolase target
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Toluidine-Blue ACHE BCHE Dye Drug Phenothiazine Sulfur Compound
Phenothiazine ACHE Phenothiazine Not AlphaBeta Hydrolase target Multitarget Drug Sulfur Compound
Posiphen ACHE Derivative of physostigmine-eserine Carbamate Drug Indole
Phenserine ACHE Derivative of physostigmine-eserine Carbamate Drug Indole
Physostigmine~Eserine ACHE BCHE Arylacetamide_deacetylase Derivative of physostigmine-eserine Natural Carbamate Drug Indole
Procaine BCHE Local anesthetic Drug Not AlphaBeta Hydrolase target
Promazine ACHE BCHE Phenothiazine Drug Sulfur Compound Not AlphaBeta Hydrolase target
Promethazine ACHE BCHE Phenothiazine Drug Not AlphaBeta Hydrolase target Muscarinic antagonist Sulfur Compound
Distigmine BCHE Carbamate Drug Pyridine
Pyridostigmine BCHE ACHE Carbamate Drug Pyridine
Tetracaine BCHE Local anesthetic Drug Not AlphaBeta Hydrolase target
Vecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperidine Drug Acetate Not AlphaBeta Hydrolase target
Tamoxifen Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target
Mevastatin Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target Naphthalen Antibiotic
Terbutaline Not AlphaBeta Hydrolase target Drug tert-Butyl Derivative of Bambuterol
Rocuronium Neuromuscular Nondepolarizing Agents Aminosteroid Drug Not AlphaBeta Hydrolase target Morpholine Phenanthrene
Amiloride ACHE BCHE Carboxamide Drug Pyridine Not AlphaBeta Hydrolase target