Fluoro-piperidin-ethyl-carbazole-15g
Selective potent BChE inhibitor. AChE IC50 > 100 microM BChE IC50 0.11 microM
General
Type : Piperidine, Carbazol
Chemical_Nomenclature : 6-Fluoro-9-(2-(piperidin-1-yl)ethyl)-2,3,4,9-tetrahydro-1h-carbazole
Canonical SMILES : C1CCN(CC1)CCN2C3=C(CCCC3)C4=C2C=CC(=C4)F
InChI : InChI=1S\/C19H25FN2\/c20-15-8-9-19-17(14-15)16-6-2-3-7-18(16)22(19)13-12-21-10-4-1-5-11-21\/h8-9,14H,1-7,10-13H2
InChIKey : ODORLMFVAVYSGE-UHFFFAOYSA-N
Other name(s) : 1-(2-(6-fluoro-1,2,3,4-tetrahydro-9H-carbazole-9-yl)ethyl)piperidin-1-ium chloride || 15g
MW : 336.9
Formula : C19H26ClFN2 || C19H25FN2
CAS_number :
PubChem : 137554851, 137554836
UniChem : ODORLMFVAVYSGE-UHFFFAOYSA-N
Target
Families : Fluoro-piperidin-ethyl-carbazole-15g ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Design, synthesis, in vivo and in vitro studies of 1,2,3,4-tetrahydro-9H-carbazole derivatives, highly selective and potent butyrylcholinesterase inhibitors - Ghobadian_2020_Mol.Divers_24_211 |
| Author(s) : Ghobadian R , Esfandyari R , Nadri H , Moradi A , Mahdavi M , Akbarzadeh T , Khaleghzadeh-Ahangar H , Edraki N , Sharifzadeh M , Amini M |
| Ref : Mol Divers , 24 :211 , 2020 |
| Abstract : |
| PubMedSearch : Ghobadian_2020_Mol.Divers_24_211 |
| PubMedID: 30927138 |