Fluorobenzyl-dimethoxy-oxobenzofuran-pyridinium-Cpd5b
IC50 AChE 52 +/- 6.38 nM, IC50 BChE 1620 +/- 73 nM. 5,6-dimethoxybenzofuranone derivatives were slightly diminished, compared to 6-alkoxy benzofuranone derivatives that were previously reported Nadri_2010_Bioorg.Med.Chem_18_6360 Aurone-Donepezil-Cpd6b
General
Type : Flavonoid, Benzofuran, Multitarget, Derivative of Donepezil, Pyridine, Pyridinium
Chemical_Nomenclature : (Z)-1-(2-Fluorobenzyl)-4-((5,6-dimethoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium bromide
Canonical SMILES : C1(=CC=[N+](C=C1)CC2=CC=CC=C2F)C=C3C(C4=C(O3)C=C(C(=C4)OC)OC)=O.[Br-]
InChI : InChI=1S\/C23H19FNO4.BrH\/c1-27-20-12-17-19(13-21(20)28-2)29-22(23(17)26)11-15-7-9-25(10-8-15)14-16-5-3-4-6-18(16)24\;\/h3-13H,14H2,1-2H3\;1H\/q+1\;\/p-1
InChIKey : ZEQIAYGAIABYGW-UHFFFAOYSA-M
Other name(s) : Compound 5b
Target
Families : Fluorobenzyl-dimethoxy-oxobenzofuran-pyridinium-Cpd5b ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : 5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase\/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety - Nadri_2013_Daru_21_15 |
| Author(s) : Nadri H , Pirali-Hamedani M , Moradi A , Sakhteman A , Vahidi A , Sheibani V , Asadipour A , Hosseinzadeh N , Abdollahi M , Shafiee A , Foroumadi A |
| Ref : Daru , 21 :15 , 2013 |
| Abstract : |
| PubMedSearch : Nadri_2013_Daru_21_15 |
| PubMedID: 23445881 |