Fluorosulfate-chlorophenyl-phenyl-pyrazol-CpdK3
eqBuChE and hBuChE inhibition IC50 = 0.79 microM and 6.59 microM. Mixed and non-competitive BuChE inhibitor Ki = 0.77 microM
General
Type : Sulfur Compound, Organochlorine, Pyrazole
Chemical_Nomenclature : 1-(4-Chlorophenyl)-3-phenyl-1H-pyrazol-5-yl sulfurofluoridate
Canonical SMILES : C1=C(C=CC(=C1)[N]2N=C(C=C2O[S](=O)(=O)F)C3=CC=CC=C3)Cl
InChI : InChI=1S\/C15H10ClFN2O3S\/c16-12-6-8-13(9-7-12)19-15(22-23(17,20)21)10-14(18-19)11-4-2-1-3-5-11\/h1-10H
InChIKey : PKSMREUTGQKWMI-UHFFFAOYSA-N
Other name(s) : Compound K3
Target
Families : Fluorosulfate-chlorophenyl-phenyl-pyrazol-CpdK3 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Fluorosulfate-containing pyrazole heterocycles as selective BuChE inhibitors: structure-activity relationship and biological evaluation for the treatment of Alzheimer's disease - Li_2022_J.Enzyme.Inhib.Med.Chem_37_2099 |
| Author(s) : Li HH , Wu C , Zhang SL , Yang JG , Qin HL , Tang W |
| Ref : J Enzyme Inhib Med Chem , 37 :2099 , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_J.Enzyme.Inhib.Med.Chem_37_2099 |
| PubMedID: 35899776 |