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Fmoc-Lys(Boc)-trimethylammonium-5e

IC50 hBCHE Lys(Boc) (5e) 0.14 +/- 0.05 microM

General

Type : Fluoren, Carbamate, Trimethylammonium

Chemical_Nomenclature : tert-Butyl N-[(5S)-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-{[2-(trimethylazaniumyl)ethyl]carbamoyl}pentyl]carbamate iodide

Canonical SMILES : C1(COC(N[C@H](C(NCC[N+](C)(C)C)=O)CCCCNC(OC(C)(C)C)=O)=O)C3=C(C2=C1C=CC=C2)C=CC=C3.[I-]

InChI : InChI=1S\/C31H44N4O5.HI\/c1-31(2,3)40-29(37)33-18-12-11-17-27(28(36)32-19-20-35(4,5)6)34-30(38)39-21-26-24-15-9-7-13-22(24)23-14-8-10-16-25(23)26\;\/h7-10,13-16,26-27H,11-12,17-21H2,1-6H3,(H2-,32,33,34,36,37,38)\;1H\/t27-\;\/m0.\/s1

InChIKey : GJCMOZYBUXHHIC-YCBFMBTMSA-N

Other name(s) : Fmoc-Lys(Boc)-trimethylammonium amide analog (5e)  ||  Compound 5e

MW : 680.625

Formula : C31H45IN4O5

CAS_number :

PubChem :

UniChem : GJCMOZYBUXHHIC-YCBFMBTMSA-N

Target

Families : Fmoc-Lys(Boc)-trimethylammonium-5e ligand of proteins in family
BCHE

Protein :
human-BCHE

References (1)

Title : Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors - Godinez_2023_Bioorg.Med.Chem.Lett__129392
Author(s) : Godinez J , Lee CY , Schwans JP
Ref : Bioorganic & Medicinal Chemistry Lett , :129392 , 2023
Abstract :
PubMedSearch : Godinez_2023_Bioorg.Med.Chem.Lett__129392
PubMedID: 37364726