Trimethylammonium

General

Charged part of the choline product of hydrolysis of Acetylcholine. Binds the anionic sites (CAS and PAS) of acetylcholinesterase. Building block for many inhibitors of cholinesterase (analogy with substrate gives the high afinity)

Inhibitor	Main targeted enzyme families	Type
8AM2-N0C	BCHE	Trimethylammonium Pyridine
8AM1-5a	BCHE	Trimethylammonium Pyridine
Cetrimonium		Trimethylammonium
T-1123	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Nerve Agent Carbamate
EA-4056	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3990	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Bisquaternary Nerve Agent Carbamate Pyridine
BisQ	ACHE	Analogue of substrate Trimethylammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch
p-phenylazophenyltrimethylammonium		Photoswitch Trimethylammonium Not AlphaBeta Hydrolase target Nicotinic agonist
N-p-phenylazophenylcarbamylcholine		Photoswitch Trimethylammonium Not AlphaBeta Hydrolase target Nicotinic agonist
Carpronium	ACHE	Analogue of substrate Trimethylammonium
NBD-5-acylcholine	ACHE	Trimethylammonium Analogue of substrate NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole
AMTS13	ACHE	Trimethylammonium Sulfur Compound
Demecarium	ACHE BCHE	Trimethylammonium Bisquaternary Drug
3-Hydroxy-Phenyl-Trimethyl-Ammonium	ACHE	Trimethylammonium
3-Trimethylammonium-aniline	ACHE	Trimethylammonium
4-Trimethylammonium-aniline	ACHE	Trimethylammonium
BW62C47	ACHE	Bisquaternary Trimethylammonium
4-hydroxy-N,N,N-trimethylpentanaminium	ACHE	Trimethylammonium Analogue of substrate
4-oxo-N,N,N-trimethylpentanaminium	ACHE	Trimethylammonium Analogue of substrate
Carbachol	ACHE BCHE	Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
CHMP-thiocholine	ACHE	Organophosphate Trimethylammonium Sulfur Compound
Choline	ACHE BCHE	Natural Trimethylammonium
Decamethonium	BCHE	Bisquaternary Trimethylammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Decidium	ACHE	Bisquaternary Trimethylammonium Phenanthridinium
Nu-1250	ACHE	Carbamate Trimethylammonium
Nu-1197	ACHE	Carbamate Trimethylammonium
DMBMP-thiocholine	ACHE	Organophosphate Trimethylammonium Sulfur Compound
Echothiophate	BCHE	Drug Organophosphate Sulfur Compound Organothiophosphate Trimethylammonium
Hexamethonium	ACHE	Bisquaternary Nicotinic antagonist Trimethylammonium
Neostigmine~Prostigmine	ACHE BCHE	Carbamate Trimethylammonium
Fmoc-Lys(Boc)-trimethylammonium-5e	BCHE	Fluoren Carbamate Trimethylammonium
Ro-2-0683	BCHE	Trimethylammonium Carbamate
Succinylcholine~Suxamethonium	BCHE	Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Not AlphaBeta Hydrolase target
Tetramethylammonium	ACHE	Quaternary compound Trimethylammonium
TMAmethylborinicacid	ACHE	Quaternary compound Trimethylammonium Boron Compound
TMTFA	ACHE	Trifluoro Trimethylammonium Quaternary compound Transition state analogue Halo ketone