Trimethylammonium

General

Charged part of the choline product of hydrolysis of Acetylcholine. Binds the anionic sites (CAS and PAS) of acetylcholinesterase. Building block for many inhibitors of cholinesterase (analogy with substrate gives the high afinity)

Inhibitor	Main targeted enzyme families	Type
8AM2-N0C	BCHE	Trimethylammonium Ammonium Pyridine Hydrazinylidene Hydrazide
Thiocholine-thionitrobenzoic-acid	BCHE	Trimethylammonium Ammonium Sulfur Compound Benzoate
8AM1-5a	BCHE	Trimethylammonium Ammonium Pyridine
Cetrimonium		Trimethylammonium Ammonium
MFPhCh	ACHE	Tammelin ester Organophosphate Choline ester Trimethylammonium Ammonium
MFPCh	ACHE	Tammelin ester Organophosphate Choline ester Trimethylammonium Ammonium
MFPbetaCh	ACHE	Tammelin ester Organophosphate Choline ester Trimethylammonium Ammonium
3152-CT		Carbamate Chemical Warfare Agent Trimethylammonium Ammonium Nerve Agent Carbamate
EA-3966	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
BisQ	ACHE	Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch Diazenyl
p-phenylazophenyltrimethylammonium	ACHE	Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
N-p-phenylazophenylcarbamylcholine	ACHE	Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
Hypaphorine	ACHE	Not AlphaBeta Hydrolase target Natural Derivative of Tryptophan Indole Propionate Trimethylammonium Ammonium
Carpronium	ACHE	Analogue of substrate Trimethylammonium Ammonium
NBD-5-acylcholine	ACHE	Trimethylammonium Ammonium Analogue of substrate NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole
AMTS13	ACHE	Tridecyl Trimethylammonium Ammonium Sulfur Compound
Demecarium	ACHE BCHE	Trimethylammonium Ammonium Bisquaternary Drug
3-Hydroxy-Phenyl-Trimethyl-Ammonium	ACHE	Trimethylammonium Ammonium
3-Trimethylammonium-aniline	ACHE	Trimethylammonium Ammonium
4-Trimethylammonium-aniline	ACHE	Trimethylammonium
BW62C47	ACHE	Bisquaternary Trimethylammonium Ammonium
4-hydroxy-N,N,N-trimethylpentanaminium	ACHE	Trimethylammonium Ammonium Analogue of substrate
4-oxo-N,N,N-trimethylpentanaminium	ACHE	Trimethylammonium Ammonium Analogue of substrate
Carbachol	ACHE BCHE	Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Ammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
CHMP-thiocholine	ACHE	Organophosphate Trimethylammonium Ammonium Sulfur Compound
Choline	ACHE BCHE	Natural Trimethylammonium Ammonium
Decamethonium	BCHE	Bisquaternary Trimethylammonium Ammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Decidium	ACHE	Bisquaternary Trimethylammonium Ammonium Phenanthridinium Derivative of Propidium
Nu-1250	ACHE	Carbamate Trimethylammonium Ammonium Organochlorine
Nu-1197	ACHE	Carbamate Trimethylammonium Ammonium
DMBMP-thiocholine	ACHE	Organophosphate Trimethylammonium Ammonium Sulfur Compound
Echothiophate	BCHE	Drug Organophosphate Sulfur Compound Organothiophosphate Trimethylammonium Ammonium
Edrophonium	ACHE BCHE	Drug Quaternary compound Trimethylammonium Ammonium Organochlorine
Hexamethonium	ACHE	Bisquaternary Nicotinic antagonist Trimethylammonium Ammonium
Neostigmine~Prostigmine	ACHE BCHE	Stigmine Derivative of Neostigmine~Prostigmine Carbamate Trimethylammonium Ammonium
Fmoc-Lys(Boc)-trimethylammonium-5e	BCHE	Fluoren Carbamate Trimethylammonium Ammonium
Ro-2-0683	BCHE	Trimethylammonium Ammonium Carbamate
Succinylcholine~Suxamethonium	BCHE	Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Ammonium Not AlphaBeta Hydrolase target
Tetramethylammonium	ACHE	Quaternary compound Trimethylammonium Ammonium
TMAmethylborinicacid	ACHE	Quaternary compound Trimethylammonium Ammonium Boron compound
NAF	ACHE	Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
TMTFA	ACHE	Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone