Hexyl-dcp

Neuropathy target esterase (NTE) (PNPLA6 not an alpha/beta hydrolase but a patatin fold) is the paraoxon-resistant and mipafox-sensitive phenyl valerate (PV) esterase activity. Some organophosphorus compounds (OPs) induce a organophosphorus-induced delayed neuropathy (OPIDN) related to the covalent inhibition and aging of NTE. HDCP is an OPIDN organophosphate poor substrate of NTE (Warning there is another OP compound called HDCP Hexyl 2,5-dichlorophenylphosphoroamidate CID 53998941 O-hexyl-O-2,5-dichlorophenyl-phosphoramidate)

General

Type : Organophosphate, Not A\/B H target, OPIDN-OP

Chemical_Nomenclature : N-(2,5-dichlorophenyl)-hexoxyphosphonamidic acid

Canonical SMILES : CCCCCCOP(=O)(NC1=C(C=CC(=C1)Cl)Cl)O

InChI : InChI=1S\/C12H18Cl2NO3P\/c1-2-3-4-5-8-18-19(16,17)15-12-9-10(13)6-7-11(12)14\/h6-7,9H,2-5,8H2,1H3,(H2,15,16,17)

InChIKey : KFTDOKAFZCTUQM-UHFFFAOYSA-N

Other name(s) : Hexyl 2,5-dichlorophenylphosphoroamidate  ||  N-(2,5-dichlorophenyl)-hexoxyphosphonamidic acid  ||  O-Hexyl O-2,5-dichlorophenylphosphoroamidate  ||  SCHEMBL6268257  ||  O-Hexil O-2,5-diclorofenil fosforamidate


MW : 326.15

Formula : C12H18Cl2NO3P

CAS_number : 109791-13-1

PubChem : 131041,    57346670

UniChem : KFTDOKAFZCTUQM-UHFFFAOYSA-N

Target

References (18)

Title : DAEH N-terminal sequence of avian serum albumins as catalytic center of Cu (II)-dependent organophosphorus hydrolyzing A-esterase activity - Monroy-Noyola_2021_Chem.Biol.Interact__109524
Author(s) : Monroy-Noyola A , Sogorb MA , Almenares-Lopez D , Vilanova E
Ref : Chemico-Biological Interactions , :109524 , 2021
Abstract :
PubMedSearch : Monroy-Noyola_2021_Chem.Biol.Interact__109524
PubMedID: 34022193

Title : O-hexyl O-2,5-dichlorophenyl phosphoramidate as a substrate for domestic and sea bird serum A-esterases: Hydrolysis levels, Cu(2+)- and Zn(2+)-dependence and stereoselectivity - Monroy-Noyola_2019_Chem.Biol.Interact_13ChEPon_310_108727
Author(s) : Monroy-Noyola A , Vilanova E , Campos F , Mederos P , Rendon N , Garcia-Hernandez J , Castillo-Guerrero JA , Rios C
Ref : Chemico-Biological Interactions , 310 :108727 , 2019
Abstract :
PubMedSearch : Monroy-Noyola_2019_Chem.Biol.Interact_13ChEPon_310_108727
PubMedID: 31251899

Title : Albumin, the responsible protein of the Cu(2+)-dependent hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) by chicken serum antagonistic stereoselectivity - Monroy-Noyola_2018_Food.Chem.Toxicol_120_523
Author(s) : Monroy-Noyola A , Sogorb MA , Vilanova E
Ref : Food & Chemical Toxicology , 120 :523 , 2018
Abstract :
PubMedSearch : Monroy-Noyola_2018_Food.Chem.Toxicol_120_523
PubMedID: 30056146

Title : Stereospecific hydrolysis of a phosphoramidate used as an OPIDP model by human sera with PON1 192 alloforms - Monroy-Noyola_2015_Arch.Toxicol_89_1801
Author(s) : Monroy-Noyola A , Trujillo B , Yescas P , Martinez-Salazar F , Garcia-Jimenez S , Rios C , Vilanova E
Ref : Archives of Toxicology , 89 :1801 , 2015
Abstract :
PubMedSearch : Monroy-Noyola_2015_Arch.Toxicol_89_1801
PubMedID: 25112958

Title : Serum albumins and detoxication of anti-cholinesterase agents - Sogorb_2010_Chem.Biol.Interact_187_325
Author(s) : Sogorb MA , Vilanova E
Ref : Chemico-Biological Interactions , 187 :325 , 2010
Abstract :
PubMedSearch : Sogorb_2010_Chem.Biol.Interact_187_325
PubMedID: 20211614

Title : Comparative hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate and paraoxon in different tissues of vertebrates - Monroy-Noyola_2007_Arch.Toxicol_81_689
Author(s) : Monroy-Noyola A , Rojas P , Vilanova E , Sogorb MA
Ref : Archives of Toxicology , 81 :689 , 2007
Abstract :
PubMedSearch : Monroy-Noyola_2007_Arch.Toxicol_81_689
PubMedID: 17396245

Title : Stereospecific hydrolysis of a phosphoramidate as a model to understand the role of biotransformation in the neurotoxicity of chiral organophosphorus compounds - Monroy-Noyola_2007_Toxicol.Lett_170_157
Author(s) : Monroy-Noyola A , Sogorb MA , Vilanova E
Ref : Toxicol Lett , 170 :157 , 2007
Abstract :
PubMedSearch : Monroy-Noyola_2007_Toxicol.Lett_170_157
PubMedID: 17420104

Title : Recovery of neuropathy target esterase activity after inhibition with mipafox and O-hexyl O-2,5-dichlorophenyl phosphoramidate in bovine chromaffin cell cultures - Quesada_2007_Chem.Biol.Interact_165_99
Author(s) : Quesada E , Sabater E , Sogorb MA , Vilanova E , Carrera V
Ref : Chemico-Biological Interactions , 165 :99 , 2007
Abstract :
PubMedSearch : Quesada_2007_Chem.Biol.Interact_165_99
PubMedID: 17184757

Title : Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity - Monroy-Noyola_1999_Chem.Biol.Interact_119-120_257
Author(s) : Monroy-Noyola A , Sogorb MA , Diaz-Alejo N , Niguez N , Barril J , Vicedo JL , Escudero MA , Vilanova E
Ref : Chemico-Biological Interactions , 119-120 :257 , 1999
Abstract :
PubMedSearch : Monroy-Noyola_1999_Chem.Biol.Interact_119-120_257
PubMedID: 10421460

Title : EDTA-resistant and sensitive phosphotriesterase activities associated with albumin and lipoproteins in rabbit serum - Sogorb_1999_Drug.Metab.Dispos_27_53
Author(s) : Sogorb MA , Sanchez I , Lopez-Rivadulla M , Cespedes V , Vilanova E
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 27 :53 , 1999
Abstract :
PubMedSearch : Sogorb_1999_Drug.Metab.Dispos_27_53
PubMedID: 9884309

Title : Phosphotriesterase activity identified in purified serum albumins - Sogorb_1998_Arch.Toxicol_72_219
Author(s) : Sogorb MA , Diaz-Alejo N , Escudero MA , Vilanova E
Ref : Archives of Toxicology , 72 :219 , 1998
Abstract :
PubMedSearch : Sogorb_1998_Arch.Toxicol_72_219
PubMedID: 9587017

Title : A stereospecific phosphotriesterase in hen liver and brain - Diaz-Alejo_1998_Chem.Biol.Interact_108_187
Author(s) : Diaz-Alejo N , Monroy A , Vilanova E , Vicedo JL , Sogorb MA
Ref : Chemico-Biological Interactions , 108 :187 , 1998
Abstract :
PubMedSearch : Diaz-Alejo_1998_Chem.Biol.Interact_108_187
PubMedID: 9528689

Title : Inhibition and aging of neuropathy target esterase by the stereoisomers of a phosphoramidate related to methamidophos - Sogorb_1997_Toxicol.Lett_93_95
Author(s) : Sogorb MA , Diaz-Alejo N , Pellin MC , Vilanova E
Ref : Toxicol Lett , 93 :95 , 1997
Abstract :
PubMedSearch : Sogorb_1997_Toxicol.Lett_93_95
PubMedID: 9486944

Title : Non-calcium dependent activity hydrolysing organophosphorus compounds in hen plasma - Diaz-Alejo_1994_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_107_213
Author(s) : Diaz-Alejo N , Sogorb MA , Vicedo JL , Barril J , Vilanova E
Ref : Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology , 107 :213 , 1994
Abstract :
PubMedSearch : Diaz-Alejo_1994_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_107_213
PubMedID: 7749589

Title : Chiral high-performance liquid chromatography and gas chromatography of the stereoisomers of hexyl 2,5-dichlorophenyl phosphoramidate - Diaz-Alejo_1993_J.Chromatogr_622_179
Author(s) : Diaz-Alejo N , Vilanova E
Ref : Journal of Chromatography , 622 :179 , 1993
Abstract :
PubMedSearch : Diaz-Alejo_1993_J.Chromatogr_622_179
PubMedID: 8150866

Title : Effect of some metallic cations and organic compounds on the O-hexyl O-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma - Sogorb_1993_Arch.Toxicol_67_416
Author(s) : Sogorb MA , Diaz-Alejo N , Vilanova E , Vicedo JL , Carrera V
Ref : Archives of Toxicology , 67 :416 , 1993
Abstract :
PubMedSearch : Sogorb_1993_Arch.Toxicol_67_416
PubMedID: 8215911

Title : The kinetics of O-hexyl O-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma - Sogorb_1993_Chem.Biol.Interact_87_117
Author(s) : Sogorb MA , Vilanova E , Diaz-Alejo N
Ref : Chemico-Biological Interactions , 87 :117 , 1993
Abstract :
PubMedSearch : Sogorb_1993_Chem.Biol.Interact_87_117
PubMedID: 8343971

Title : Hen liver and plasma can metabolize hexyl-DCP phosphoramidate at a rate comparable to that of rat - Diaz-Alejo_1990_Neurotoxicol.Teratol_12_615
Author(s) : Diaz-Alejo N , Pellin MC , Vicedo JL , Vilanova E
Ref : Neurotoxicology & Teratology , 12 :615 , 1990
Abstract :
PubMedSearch : Diaz-Alejo_1990_Neurotoxicol.Teratol_12_615
PubMedID: 2255303