Hydroxy-bis(piperidin-1-ylmethyl)benzylidene)-dihydro-inden-one-Cpd9
hCA I Ki = 46.828 11.32 nM and AChE Ki = 0.9820 0.402 nM
General
Type : Multitarget, Carbonic anhydrase inhibitor, Piperidine, Indole, Inden
Chemical_Nomenclature : 2-(2-Hydroxy-3,5-bis(piperidin-1-ylmethyl)benzylidene)-2,3-dihydro-1H-inden-1-one
Canonical SMILES : C1=C(C(=C(C=C1CN2CCCCC2)CN3CCCCC3)O)C=C4C(C5=C(C4)C=CC=C5)=O
InChI : InChI=1S\/C28H34N2O2\/c31-27-23(18-24-17-22-9-3-4-10-26(22)28(24)32)15-21(19-29-11-5-1-6-12-29)16-25(27)20-30-13-7-2-8-14-30\/h3-4,9-10,15-16,18,31H,1-2,5-8,11-14,17,19-20H2
InChIKey : INFNOJAISSUAKT-UHFFFAOYSA-N
Other name(s) : compound 9
benzylidene)-dihydro-inden-one-Cpd9.gif)
Target
Families : Hydroxy-bis(piperidin-1-ylmethyl)benzylidene)-dihydro-inden-one-Cpd9 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Indanone-Based Mannich Bases: Design, Synthesis, In-Silico Molecular Docking, ADME Predictions and Biological Evaluation Including Carbonic Anhydrases, Acetylcholinesterase Inhibition and Cytotoxicities - Sakarya_2025_Arch.Biochem.Biophys__110511 |
| Author(s) : Sakarya MT , Gul HI , Sakagami H , Sert Y , Taslimi P , Gulcin I |
| Ref : Archives of Biochemistry & Biophysics , :110511 , 2025 |
| Abstract : |
| PubMedSearch : Sakarya_2025_Arch.Biochem.Biophys__110511 |
| PubMedID: 40523513 |