Imidazo-thiadiazole-cpd20aa
eeAChE, IC50 = 0.75 microM; eqBChE, IC50 = 4.11 microM
General
Type : Triazol, Thiadiazol, Sulfur Compound, Trifluoro, Imidazole
Chemical_Nomenclature :
Canonical SMILES : S1C(=N[N]2C1=NC(=C2)C3=CC=C(C=C3)C(F)(F)F)SCC(NCC4=CC(=CC=C4)C(NCC5=CC=C(C=C5)C(F)(F)F)=O)=O
InChI : InChI=1S\/C29H21F6N5O2S2\/c30-28(31,32)21-8-4-17(5-9-21)13-37-25(42)20-3-1-2-18(12-20)14-36-24(41)16-43-27-39-40-15-23(38-26(40)44-27)19-6-10-22(11-7-19)29(33,34)35\/h1-12,15H,13-14,16H2,(H,36,41)(H,37,42)
InChIKey : IQEQPGFGALQZHC-UHFFFAOYSA-N
Other name(s) : Compound 20aa
Target
Families : Imidazo-thiadiazole-cpd20aa ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis, biological evaluation, and in silico studies of imidazo[2,1-b][1,3,4]thiadiazole derivatives as cholinesterase inhibitors - Du_2025_Med.Chem.Res__ |
| Author(s) : Du WR , Wang YX , Zhou XW , Lan Y , Wei BB , Guo XY , Wang XK , Ma ZY |
| Ref : Med Chem Res , : , 2025 |
| Abstract : |
| PubMedSearch : Du_2025_Med.Chem.Res__ |
| PubMedID: |