Thiadiazol

General

Five-membered heterocyclic compounds containing one sulfur and two nitrogen atoms. Building block for many inhibitors of enzymes

Inhibitor	Main targeted enzyme familyes	Type
JZP-430	ABHD6-Lip	Carbamate Morpholine Sulfur Compound Thiadiazol
JZP-MA-11	ABHD6-Lip	Sulfur Compound PET probe Thiadiazol Piperidine Carbamate
Lalistat-alkyne-probe	Acidic_Lipase 6_AlphaBeta_hydrolase Cutinase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip	Piperidine Lipase inhibitor Sulfur Compound Thiadiazol Alkyne ABPP-Probe
N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t	ACHE	Sulfur Compound Pyridine Thiadiazol
Fragment-955	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Sulfur Compound Thiadiazol
Fragment-276	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Sulfur Compound Thiadiazol
TDZD8	Pectinacetylesterase-Notum	Not A\/B H target GSK-3 kinase inhibitor Thiadiazol Sulfur Compound
Lalistat-1	Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase	Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
Lalistat-2	Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase	Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
P9-benzothiadiazole	Haloalkane_dehalogenase-HLD2	Sulfur Compound Fluorescent Probe Thiadiazol Sulfonyl
Methidathion	ACHE	Organophosphate Insecticide Sulfur Compound Organothiophosphate Thiadiazol